TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11196172
rs11196172
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0009402
Disease:
Colorectal Carcinoma
A 0.820 GeneticVariation GWASCAT Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer. 30529582 2019
dbSNP: rs11196172
rs11196172
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0009402
Disease:
Colorectal Carcinoma
A 0.820 GeneticVariation GWASCAT GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12. 29471430 2018
dbSNP: rs11196172
rs11196172
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0009402
Disease:
Colorectal Carcinoma
0.820 GeneticVariation BEFREE Cumulative epidemiological evidence of an association was graded as strong for rs7903146 [odds ratio (OR) = 1.05, p = 4.13 × 10<sup>-5</sup> ] and rs7904519 (OR = 1.07, p = 2.02 × 10<sup>-14</sup> ) in breast cancer, rs11196172 (OR = 1.11, p = 2.22 × 10<sup>-16</sup> ), rs12241008 (OR = 1.13, p = 1.36 × 10<sup>-10</sup> ) and rs10506868 (OR = 1.10, p = 3.98 × 10<sup>-9</sup> ) in colorectal cancer, rs7086803 in lung cancer (OR = 1.30, p = 3.54 × 10<sup>-18</sup> ) and rs11196067 (OR = 1.18, p = 3.59 × 10<sup>-13</sup> ) in glioma, moderate for rs12255372 (OR = 1.12, p = 2.52 × 10<sup>-4</sup> ) in breast cancer and weak for rs7903146 (OR = 1.11, p = 0.007) in colorectal cancer. 28949031 2018
dbSNP: rs11196172
rs11196172
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0009402
Disease:
Colorectal Carcinoma
0.820 GeneticVariation BEFREE The results indicated that the TCF7L2 rs11196172 polymorphism increases the risk of CRC independently, with no evidence of an interaction with diabetes or obesity. 27792933 2016
dbSNP: rs11196172
rs11196172
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0009402
Disease:
Colorectal Carcinoma
A 0.820 GeneticVariation GWASCAT Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. 26965516 2016
dbSNP: rs11196172
rs11196172
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0009402
Disease:
Colorectal Carcinoma
A 0.820 GeneticVariation GWASCAT Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. 24836286 2014
dbSNP: rs11196172
rs11196172
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0009402
Disease:
Colorectal Carcinoma
A 0.820 GeneticVariation GWASDB Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. 24836286 2014
dbSNP: rs11196170
rs11196170
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0009402
Disease:
Colorectal Carcinoma
A 0.700 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241 2019
dbSNP: rs12255372
rs12255372
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0009402
Disease:
Colorectal Carcinoma
0.030 GeneticVariation BEFREE We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110). 31485167 2019
dbSNP: rs12255372
rs12255372
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0009402
Disease:
Colorectal Carcinoma
0.030 GeneticVariation BEFREE Cumulative epidemiological evidence of an association was graded as strong for rs7903146 [odds ratio (OR) = 1.05, p = 4.13 × 10<sup>-5</sup> ] and rs7904519 (OR = 1.07, p = 2.02 × 10<sup>-14</sup> ) in breast cancer, rs11196172 (OR = 1.11, p = 2.22 × 10<sup>-16</sup> ), rs12241008 (OR = 1.13, p = 1.36 × 10<sup>-10</sup> ) and rs10506868 (OR = 1.10, p = 3.98 × 10<sup>-9</sup> ) in colorectal cancer, rs7086803 in lung cancer (OR = 1.30, p = 3.54 × 10<sup>-18</sup> ) and rs11196067 (OR = 1.18, p = 3.59 × 10<sup>-13</sup> ) in glioma, moderate for rs12255372 (OR = 1.12, p = 2.52 × 10<sup>-4</sup> ) in breast cancer and weak for rs7903146 (OR = 1.11, p = 0.007) in colorectal cancer. 28949031 2018
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0009402
Disease:
Colorectal Carcinoma
0.030 GeneticVariation BEFREE Cumulative epidemiological evidence of an association was graded as strong for rs7903146 [odds ratio (OR) = 1.05, p = 4.13 × 10<sup>-5</sup> ] and rs7904519 (OR = 1.07, p = 2.02 × 10<sup>-14</sup> ) in breast cancer, rs11196172 (OR = 1.11, p = 2.22 × 10<sup>-16</sup> ), rs12241008 (OR = 1.13, p = 1.36 × 10<sup>-10</sup> ) and rs10506868 (OR = 1.10, p = 3.98 × 10<sup>-9</sup> ) in colorectal cancer, rs7086803 in lung cancer (OR = 1.30, p = 3.54 × 10<sup>-18</sup> ) and rs11196067 (OR = 1.18, p = 3.59 × 10<sup>-13</sup> ) in glioma, moderate for rs12255372 (OR = 1.12, p = 2.52 × 10<sup>-4</sup> ) in breast cancer and weak for rs7903146 (OR = 1.11, p = 0.007) in colorectal cancer. 28949031 2018
dbSNP: rs12255372
rs12255372
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0009402
Disease:
Colorectal Carcinoma
0.030 GeneticVariation BEFREE The results demonstrate that patients with the T/T genotype for the rs12255372 polymorphism of the TCF7L2 gene present an increased colorectal cancer risk (OR=2.64, P=0.0236). 27755946 2016
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0009402
Disease:
Colorectal Carcinoma
0.030 GeneticVariation BEFREE Patients carrying the TCF7L2_rs7903146_T allele had an increased risk of CRC (P(trend) = 0.02), whereas patients harboring the IL13_rs20541_T allele had a reduced risk (P(trend) = 0.02). 22419714 2012
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0009402
Disease:
Colorectal Carcinoma
0.030 GeneticVariation BEFREE The T allele of rs7903146 (frequency 30%) was associated with increased risk of colorectal cancer and, more specifically, colon cancer, with adjusted hazard ratios (95% CI) of 1.0 for CC, 1.25 (0.85-1.83) for CT, and 2.15 (1.27-3.64) for TT genotypes (P(trend) = 0.009). 18268068 2008
dbSNP: rs7904519
rs7904519
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0009402
Disease:
Colorectal Carcinoma
0.010 GeneticVariation BEFREE Cumulative epidemiological evidence of an association was graded as strong for rs7903146 [odds ratio (OR) = 1.05, p = 4.13 × 10<sup>-5</sup> ] and rs7904519 (OR = 1.07, p = 2.02 × 10<sup>-14</sup> ) in breast cancer, rs11196172 (OR = 1.11, p = 2.22 × 10<sup>-16</sup> ), rs12241008 (OR = 1.13, p = 1.36 × 10<sup>-10</sup> ) and rs10506868 (OR = 1.10, p = 3.98 × 10<sup>-9</sup> ) in colorectal cancer, rs7086803 in lung cancer (OR = 1.30, p = 3.54 × 10<sup>-18</sup> ) and rs11196067 (OR = 1.18, p = 3.59 × 10<sup>-13</sup> ) in glioma, moderate for rs12255372 (OR = 1.12, p = 2.52 × 10<sup>-4</sup> ) in breast cancer and weak for rs7903146 (OR = 1.11, p = 0.007) in colorectal cancer. 28949031 2018