TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4506565
rs4506565
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.700 GeneticVariation GWASCAT Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. 27790247 2016
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE There is a trend toward an association between faster GE and the diabetes-associated allele at rs7903146 in TCF7L2. 31691451 2020
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE Genetic variation in TCF7L2 rs7903146 and history of GDM negatively and independently impact on diabetes-associated metabolic traits. 30419301 2018
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE We genotyped rs7903146 in 608 individuals without diabetes and recorded biochemical data before and after <i>1</i>) one dose of glipizide (5 mg) on visit 1 and <i>2</i>) a 75-g oral glucose tolerance test (OGTT) performed after administration of metformin 500 mg twice daily over 2 days. 29326107 2018
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE TCF7L2 rs7903146 C>T polymorphism is associated with diabetes in the general population but its independent impact on cardiovascular disease is debated. 28299838 2017
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE The TT genotype of rs7903146 was also significantly associated with higher fasting plasma insulin level and the homeostasis model assessment of insulin resistance in case of new-onset diabetes. 27998387 2016
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE We studied 120 individuals of whom one-half were homozygous for the diabetes-associated allele TT at rs7903146 and one-half were homozygous for the protective allele CC. 26525881 2016
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes. 26914832 2016
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE Human genetic studies have revealed that the T minor allele of single nucleotide polymorphism rs7903146 in the transcription factor 7-like 2 (TCF7L2) gene is strongly associated with an increased risk of diabetes by 30%-40%. 25058603 2014
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE Analysis of TCF7L2 rs7903146 in normal controls and diabetics with or without nephropathy demonstrated that the 'T' allele is associated with both diabetes (p = 0.049) and DN (p = 0.024), but this association is not independent of T2DM. 25185853 2014
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE Our study revealed no differences in the kinetics of glucose, insulin, C-peptide and non-esterified fatty acids during an OGTT in homozygous participants from a German diabetes risk cohort (n = 1832) carrying either the rs7903146 CC (n = 15) or the TT (n = 15) genotype. 24925104 2014
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE We hypothesised that both a parental history of diabetes and TCF7L2 rs7903146 polymorphism, which increases susceptibility to diabetes because of impaired beta cell function, are associated with incident hypertension. 23942764 2013
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE Diabetes-associated variation (T allele at rs7903146) in TCF7L2 may impair the ability of hyperglycemia to suppress glucagon (45 ± 2 vs. 47 ± 2 vs. 60 ± 5 ng/L for CC, CT, and TT, respectively, P = 0.02). 22461567 2012
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE Resequencing and analysis of variation in the TCF7L2 gene in African Americans suggests that SNP rs7903146 is the causal diabetes susceptibility variant. 20980453 2011
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE We recruited 189 patients with T2D being treated with SUs and determined the rs7903146 diabetes risk genotype. 21349175 2011
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE In subjects without known diabetes (n=961) recruited from the Chennai Urban Rural Epidemiology Study (CURES), OGTT, IDRS, and genotyping of rs12255372 (G/T) and rs7903146(C/T) of TCF7L2 polymorphisms were done. 21441683 2011
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE However, the T allele (conferring higher risk of diabetes) at rs7903146 was associated with higher fasting proinsulin at baseline (P<0.001), higher baseline proinsulin:insulin ratio (p<0.0001) and increased proinsulin:insulin ratio over a median of 2.5 years of follow-up (P = 0.003). 21814547 2011
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE Over an average follow-up period of 5.43 years, participants with the rs7903146 T allele or variants in the same LD block, but not those with the rs290481 G allele, were more likely to progress to diabetes (hazard ratio = 2.61, 95% confidence interval, 1.27-5.39, P = 0.009) than were non-carriers. 19806338 2010
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE For four candidate SNPs (rs780094, rs10830963, rs7903146, and rs4607517), the strength of association between genotype and glucose was significantly (P-interaction<0.05) different in those with and without prevalent diabetes, and for all five fasting glucose candidate SNPs (rs780094, rs10830963, rs560887, rs4607517, and rs13266634) the association with measured fasting glucose was more significant in the smaller sample without prevalent diabetes than in the larger combined sample of those with and without diabetes. 20839289 2010
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE We investigated the association between the TCF7L2 rs7903146 polymorphism and incident IFG defined as fasting serum glucose levels of 100-125 mg/dL (5.6-6.9 mmol/L) in 1377 African American and 5152 Caucasian participants without diabetes and IFG at intake who participated in the Atherosclerosis Risk in Communities (ARIC) Study from 1987 to 1989 and were followed for 9 years. 20578204 2010
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE A variant in TCF7L2 associated with type 2 diabetes (the T allele at rs7903146) was associated with diabetes in CF in the family study (p = 0.004) and in the case-control study (p = 0.02; combined p = 0.0002). 19585101 2009
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE Risk alleles of the TCF7L2 gene showed increased risk of diabetes even when controlled for traditional diabetes risk factors (diabetes in family, waist circumference, physical activity, BMI, SBP and total and HDL-cholesterol) in both a cross-sectional and prospective setting (cross-sectional: rs12255372 OR 1.61 (1.31-1.99), rs7903146 OR 1.48 (1.20-1.83) and prospective: rs12255372 OR 1.59 (1.22-2.07), rs7903146 OR 1.47 (1.11-1.93)). 18972257 2009
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE The TCF7L2 rs7903146 T-allele was associated with type 2 diabetes (hazard ratio=1.51</span>; 95 % CI 1.21, 1.87) and modified the inverse association between whole-grain intake and diabetes risk (P=0.016 for interaction). 19149908 2009
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE rs7903146 T allele is associated with diabetes and, in non-diabetic individuals, with a higher prevalence and severity of coronary artery disease and cardiovascular events. name of registry site (see list below), registration number, trial registration URL in brackets. 19924244 2009
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011847
Disease:
Diabetes
0.100 GeneticVariation BEFREE Our study provides the first significant evidence of association between the TCF7L2 rs7903146 polymorphism and type 2 diabetes risk in a large African American population and also demonstrates that the diabetes risk conveyed by the rs7903146 risk allele is substantially increased in the context of some metabolic risk factors for type 2 diabetes. 18931037 2009