Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12255372
rs12255372
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The meta-analysis results demonstrated that TCF7L2 rs4506565, rs7901695, rs11196205 and rs12255372 polymorphisms were all significantly associated with susceptibility to T2DM in general population. 31288068 2020
dbSNP: rs12255372
rs12255372
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Puerto Ricans with the TCF7L2-rs7903146 and rs12255372 T2D risk genotypes, although still high, had better anthropometric profiles when adhering to a MedDiet, suggesting that this diet may offset unfavorable genetic predisposition. 31504696 2020
dbSNP: rs7901695
rs7901695
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The meta-analysis results demonstrated that TCF7L2 rs4506565, rs7901695, rs11196205 and rs12255372 polymorphisms were all significantly associated with susceptibility to T2DM in general population. 31288068 2020
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Our results provide evidence that genetic variation in <i>TCF7L2</i> rs7903146 could increase risk for peripheral arterial disease in patients exhibiting long-standing type 2 diabetes. 31775533 2020
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Multivariate model analysis, including T2D status, age, and body mass index (BMI), displayed significant covariance in PPARGC-1α rs8192678; SIRT1 rs7896005; TCF7L2 rs7903146 and rs122243326; UCP3 rs3781907; and HHEX rs1111875 with a P < 0.05. 31759989 2020
dbSNP: rs12255372
rs12255372
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In conclusion, rs7903146 and rs12255372 were significantly associated with T2DM in the specified Northern Iranian population. 30776466 2019
dbSNP: rs12255372
rs12255372
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Adjusting also for T2D-related covariates, body mass index (BMI), and ancestry did not change the results substantively (rs7901695, p = 0.003; rs7903146, p = 0.005; rs11196205, p = 0.001; and rs12255372, p = 0.005). 31676834 2019
dbSNP: rs12255372
rs12255372
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE BMI and rs12255372 are associated with the risk of conversion to IGT and T2DM [OR = 1.07 (95% IC 1.0-1.14, p = .041; OR =2.14, 95% IC 1.01-4.55, p = .04 respectively), while the lactation shows a strong protective effects OR = 0.15 (95% IC 0.062-0.39, p = .00007), and an apparent interaction with rs12255372T decreasing the risk in carriers (OR =2.15; 95% IC 0.97-4.7, p = .05). 30614312 2019
dbSNP: rs7901695
rs7901695
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
C 0.900 GeneticVariation GWASCAT Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. 30718926 2019
dbSNP: rs7901695
rs7901695
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Adjusting also for T2D-related covariates, body mass index (BMI), and ancestry did not change the results substantively (rs7901695, p = 0.003; rs7903146, p = 0.005; rs11196205, p = 0.001; and rs12255372, p = 0.005). 31676834 2019
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The rs2476601C/T, rs689A/T, and rs7903146C/T polymorphisms were found to be associated with the risk of LADA, thereby indicating that, genetically, LADA could be an admixture of both T1D and T2D. 30456822 2019
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. 30814579 2019
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Adjusting also for T2D-related covariates, body mass index (BMI), and ancestry did not change the results substantively (rs7901695, p = 0.003; rs7903146</span>, p = 0.005; rs11196205, p = 0.001; and rs12255372, p = 0.005). 31676834 2019
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We investigate the association between gene variant rs7903146 and metabolic parameters and examine in vitro and ex vivo gene expression of <i>TCF7L2</i> in human adipose tissue and progenitor cells from two independent populations of young healthy men with increased risk of type 2 diabetes due to low birth weight (LBW). 30721637 2019
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE The presence of the <i>TCF7L2</i> rs7903146 T allele in patients with T2DM was associated with increased secretion of insulin response to a mixed-meal test. 30700996 2019
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In conclusion, rs7903146 and rs12255372 were significantly associated with T2DM in the specified Northern Iranian population. 30776466 2019
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Islet ATAC-seq peaks overlap with 13 SNPs associated with T2D (e.g. rs7903146, rs2237897, rs757209, rs11708067 and rs878521 near TCF7L2, KCNQ1, HNF1B, ADCY5 and GCK, respectively) and with additional 67 SNPs in LD with known T2D SNPs (e.g. 31123324 2019
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Our results suggest that the TCF7L2 rs7903146 variant affects markers of insulin resistance and glycemic response to metformin in newly diagnosed patients with T2D within the first year of metformin treatment. 31070566 2019
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASCAT Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. 31118516 2019
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Interestingly, the highest level of adropin was detected in T2DMpatients with rs7903146T/T genotype.<b>Conclusion:</b> Our analysis showed higher level of adropin in T2DM patients and increased risk of T2DM with rs7903146T/T and rs7903146C/T genotypes. 31818149 2019
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE We found that the T allele of rs7903146 was significantly associated with T2D risk (odds ratio of 1.59 for T allele, <i>p</i> = 0.005). 30899283 2019
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Fine-mapping of the TCF7L2 locus suggested one type 2 diabetes association signal shared between Europeans and Africans (indexed by rs7903146) and a distinct African-specific signal (indexed by rs17746147). 31049640 2019
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
T 0.900 GeneticVariation GWASCAT Fine-mapping of the TCF7L2 locus suggested one type 2 diabetes association signal shared between Europeans and Africans (indexed by rs7903146) and a distinct African-specific signal (indexed by rs17746147). 31049640 2019
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE In conclusion, our findings supported that <i>TCF7L2</i> rs7903146 polymorphism could be used to identify individuals at high risk of developing T2DM in Asians and Caucasians. 31312259 2019
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.900 GeneticVariation BEFREE Interestingly, the highest level of adropin was detected in T2DMpatients with rs7903146T/T genotype.<b>Conclusion:</b> Our analysis showed higher level of adropin in T2DM patients and increased risk of T2DM with rs7903146T/T and rs7903146C/T genotypes. 31818149 2019