TCF7L2, transcription factor 7 like 2, 6934

N. diseases: 257; N. variants: 70
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12255372
rs12255372
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0342546
Disease:
Premature adrenarche
0.010 GeneticVariation BEFREE The differences in the minor allele frequencies (MAFs) of rs9939609, rs7903146, and rs12255372 were not statistically significant between the PA and control groups (difference in MAFs [95% confidence interval]: -0.06 [-0.18, 0.05], 0.04 [-0.05, 0.12], and 0.01 [-0.07, 0.10]; P = .3, .4, and .8, respectively). 19497595 2009
dbSNP: rs7903146
rs7903146
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0342546
Disease:
Premature adrenarche
0.010 GeneticVariation BEFREE However, the risk allele at TCF7L2 rs7903146 was more frequent in PA subjects than in controls when we restricted the analysis to the subjects with lower weight-for-height than the median of the PA subjects (weight-for-height <108%, corresponding body mass index SD score <0.79; difference in MAFs [95% confidence interval]: 0.12 [-0.001, 0.23]; P = .038). 19497595 2009