TNFAIP3, TNF alpha induced protein 3, 7128

N. diseases: 212; N. variants: 29
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE The TT > A variants and the TNFAIP3 exon 3 coding variant rs2230926 demonstrated significant associations in SLE (P<sub>TT > A</sub> = 8.96 × 10<sup>-12</sup>, odds ratio [OR] = 2.07, 95% confidence interval [CI] = 1.68-2.55). 30529365 2019
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE A higher risk to develop SLE was observed for rs2230926 (<i>P</i> = 0.02, OR = 1.92). 31534975 2019
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation GWASCAT Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans. 26663301 2016
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation GWASCAT Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus. 27399966 2016
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE The results of our meta-analysis suggest that TNFAIP3 (rs2230926, rs5029937, rs5029939, and rs3757173) polymorphisms are associated with susceptibility to SLE. 27726311 2016
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE Associations of TNFAIP3 rs2230926 (p=1.43 × 10(-3)) and TNIP1 rs10036748 (p=4.33 × 10(-3)) with SLE were replicated in our study. 23911423 2013
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
G 0.900 GeneticVariation GWASDB Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. 23273568 2013
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
G 0.900 GeneticVariation GWASCAT Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. 23273568 2013
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE The rs2230926 allele of TNFAIP3 was associated with susceptibility to SLE in males, but after Bonferroni correction there were no significant associations with any of the other four SNPs in IRF5, BLK, TNIP1 and ETS1 genes. 24023622 2013
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE Meta-analysis revealed that an association was found between the minor allele of rs2230926 and SLE in all subjects (odds ratio [OR] 1.848, 95% confidence interval [CI] 1.547-2.208, p<1.0×10(-9)). 22924496 2012
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE We selected and identified three SNPs of BANK1 associated with SLE (rs17266594, P = 1.949e-10; OR = 1.380; 95% CI: 1.250-1.525; rs10516487, P = 2.642e-13; OR = 1.317; 95% CI: 1.223-1.417; rs3733197, P = 3.452e-06; OR = 1.193; 95% CI: 1.107-1.286); one SNP of TNFAIP3 associated with SLE (rs2230926, P = 1.502e-12; OR = 1.826; 95% CI: 1.545-2.157). 21208380 2011
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE We observed a significant association between rs2230926 and an increased risk of SLE and RA in the Japanese population (for SLE, odds ratio [OR] 1.92, 95% confidence interval [95% CI] 1.53-2.41, P = 1.9 x 10(-8); for RA, OR 1.35, 95% CI 1.18-1.56, P = 2.6 x 10(-5)). 20112363 2010
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE There are two nonsynonymous coding polymorphisms in the deubiquitinating (DUB) domain of TNFAIP3: F127C, which is in high-linkage disequilibrium with reported SLE-risk variants, and A125V, which has not been previously studied. 20483768 2010
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE Our findings suggest that SNP rs2230926 in the TNFAIP3 might be a common genetic factor for SLE within different populations in terms of Chinese Han and European population. 19774492 2010
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
C 0.900 GeneticVariation GWASCAT Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. 19838193 2009
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
C 0.900 GeneticVariation GWASDB Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. 19838193 2009
dbSNP: rs2230926
rs2230926
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0024141
Disease:
Lupus Erythematosus, Systemic
0.900 GeneticVariation BEFREE We show that three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) are associated with systemic lupus erythematosus (SLE) among individuals of European ancestry. 19165919 2008
dbSNP: rs610604
rs610604
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0033860
Disease:
Psoriasis
0.860 GeneticVariation BEFREE The results demonstrated that the SNPs rs610604 and rs17728338 of the TNFAIP3 and TNIP1 genes, respectively, were associated with psoriasis in our population at both allelic and genotypic levels. 26738398 2015
dbSNP: rs610604
rs610604
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0033860
Disease:
Psoriasis
0.860 GeneticVariation BEFREE Genome-wide association studies in white and Chinese Han populations have found that the single-nucleotide polymorphism (SNP) rs610604, at the tumour necrosis factor (TNF)-α-induced protein 3 (TNFAIP3) locus, is associated with psoriasis, and is also associated with response to TNF blockade in psoriasis. 25496073 2015
dbSNP: rs610604
rs610604
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0033860
Disease:
Psoriasis
G 0.860 GeneticVariation GWASCAT Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture. 26626624 2015
dbSNP: rs610604
rs610604
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0033860
Disease:
Psoriasis
0.860 GeneticVariation BEFREE We found a significant association between psoriasis and the single-nucleotide polymorphism rs610604, within the TNFAIP3 gene. 25406098 2015
dbSNP: rs610604
rs610604
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0033860
Disease:
Psoriasis
0.860 GeneticVariation BEFREE The results demonstrated that SNPs rs2395029, rs17728338 and rs610604 from the HCP5, TNIP1 and TNFAIP3 genes, respectively, were associated with psoriasis in the studied population at both genotype level and allelic level (P < 0.05). 25264125 2014
dbSNP: rs610604
rs610604
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0033860
Disease:
Psoriasis
0.860 GeneticVariation BEFREE The aim of our study was to analyse the presence of three different psoriasis susceptibility genetic variations (HLA-Cw6; TNFAIP3 rs610604 polymorphism; LCE3B/3C gene deletions) in a cohort of patients affected by moderate to severe psoriasis under ustekinumab treatment. 23521149 2013
dbSNP: rs610604
rs610604
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0033860
Disease:
Psoriasis
0.860 GeneticVariation BEFREE In this study, we report association of response of psoriasis to TNF blockers with two TNFAIP3 single-nucleotide polymorphisms (rs2230926 in exon 7 and rs610604 in intron 3) and their haplotypes. 22113471 2012
dbSNP: rs610604
rs610604
Entrez Id: 7128
Gene Symbol: TNFAIP3
TNFAIP3
CUI: C0033860
Disease:
Psoriasis
0.860 GeneticVariation GWASDB Association analyses identify six new psoriasis susceptibility loci in the Chinese population. 20953187 2010