UCP2, uncoupling protein 2, 7351

N. diseases: 235; N. variants: 5
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs659366
rs659366
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C1843898
Disease:
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 4 (disorder)
T 0.700 SusceptibilityMutation CLINVAR
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Overweight might modify the effects of rs660339 of UCP2 on T2DM. 29529994 2018
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE In this study, we investigated whether UCP2 -866G/A, Ala55Val and Ins/Del polymorphisms were associated with DKD in patients with type 2 diabetes mellitus (T2DM), and whether they had an effect on UCP2 gene expression in human kidney tissue biopsies. 26218518 2015
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE There was significant difference in rs660339 between DM and controls (P = 0.0016; OR [95%CI]  = 1.37 (1.14-1.65)). 25396419 2014
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Based on our case-control study and meta-analysis, we conclude that UCP2 Ala55Val and -866G/A polymorphisms are not significantly associated with type 2 diabetes risk in the Chinese population. 24065674 2013
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE In our case-control study of people with European ancestry we were not able to demonstrate any association between the UCP polymorphisms and T2DM; however, our meta-analysis detected a significant association between the UCP2 Ala55Val and UCP3 -55C/T polymorphisms and increased susceptibility for T2DM in Asians. 23365654 2013
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE In contrast, our results indicate that the UCP2 Ala55Val and UCP3 -55C/T polymorphisms may indeed be risk factors for susceptibility to type 2 diabetes in individuals of Asian descent, but not in individuals of European descent. 21751002 2011
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Ala55Val and -55C/T polymorphisms at the UCP3-2 loci are associated with a significantly reduced risk of developing type 2 diabetes in Asian Indians. 21175267 2011
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE The Ala55Val polymorphism of UCP2 was not associated with incident T2DM in the ARIC cohort. 18496642 2008
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE Moreover, the combination of the UCP2 55 Ala/Val heterozygote and the PPARgamma 161 C/C homozygote was associated with a reduced risk of Type 2 diabetes (odds ratio: 0.51, 95% CI: 0.34 to 0.77, p=0.0016). 14730379 2004
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent
0.100 GeneticVariation BEFREE These results indicate that the Ala55 --> Val and Ala232 --> Thr variants of UCP2 do not play an important role in the pathogenesis of NIDDM or obesity in the Japanese population. 9709950 1998
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0028754
Disease:
Obesity
0.080 GeneticVariation BEFREE In our case-control study we were not able to demonstrate any association between UCP polymorphisms and obesity in T2DM patients; however, in the meta-analysis we detected a significant association of UCP2 -866G/A, Ins/Del, Ala55Val and UCP3 -55C/T polymorphisms with obesity. 24752406 2014
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0028754
Disease:
Obesity
0.080 GeneticVariation BEFREE And our results did not support the association between UCP2 Ala55Val, UCP3 -55C/T polymorphisms and obesity in the populations investigated. 23560041 2013
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0028754
Disease:
Obesity
0.080 GeneticVariation BEFREE We examined the association of commonly observed UCP2 G(-866)A (rs659366) and Ala55Val (C > T) (rs660339) single nucleotide polymorphisms (SNPs) with obesity, high fasting plasma glucose, and serum lipids in a Balinese population. 22533685 2012
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0028754
Disease:
Obesity
0.080 GeneticVariation BEFREE UCP2 A55V variant might predispose to obesity and Val55 allele to confer population-attributable risk for 9.5% of obese disorders and increase insulin concentrations. 17502873 2007
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0028754
Disease:
Obesity
0.080 GeneticVariation BEFREE Ala55Val may play a crucial role in obesity development and weight loss after LAGB. 17894153 2007
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0028754
Disease:
Obesity
0.080 GeneticVariation BEFREE No association was found between the Ala55Val SNP and obesity and blood levels of insulin, glucose, and lipids as well as blood pressure and circulating hormones. 12385772 2002
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0028754
Disease:
Obesity
0.080 GeneticVariation BEFREE These results indicate that the Ala55 --> Val and Ala232 --> Thr variants of UCP2 do not play an important role in the pathogenesis of NIDDM or obesity in the Japanese population. 9709950 1998
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0028754
Disease:
Obesity
0.080 GeneticVariation BEFREE The allelic frequency of the A/V55 variant was 48.3% (95% CI: 42.5-54.1%) among 144 subjects with juvenile onset obesity, 45.6% (40.5-50.7%) among 182 subjects randomly selected at the draft board examination, and 45.5% (37.1-53.9%) among lean control subjects selected from the same study cohort. 9349606 1997
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0011849
Disease:
Diabetes Mellitus
0.050 GeneticVariation BEFREE Thus, UCP2 rs659366 A allele and rs660339 T allele are both related to longer LTL in subjects without diabetes, independent of cardiovascular risk factors. 27615599 2016
dbSNP: rs659366
rs659366
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0028754
Disease:
Obesity
0.050 GeneticVariation BEFREE To test this hypothesis, we investigated the interaction between tagging polymorphisms in the UCP2 gene (rs2306819, rs599277 and rs659366), alcohol intake and obesity traits such as BMI and waist circumference (WC) on alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) in a large meta-analysis of data sets from three populations (n=20 242). 26526553 2015
dbSNP: rs659366
rs659366
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0028754
Disease:
Obesity
0.050 GeneticVariation BEFREE We genotyped UCP2 rs659366 in a total of 17 636 Danish individuals and established case-control studies of obese and non-obese subjects and of type 2 diabetic and glucose-tolerant subjects. 22349573 2013
dbSNP: rs659366
rs659366
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0028754
Disease:
Obesity
0.050 GeneticVariation BEFREE Furthermore, rs659366 polymorphism was associated with the risk of abdominal obesity (P= 0·04: OR = 1·3; CI = 1·01-1·67). 21883184 2012
dbSNP: rs659366
rs659366
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0028754
Disease:
Obesity
0.050 GeneticVariation BEFREE We examined the association of commonly observed UCP2 G(-866)A (rs659366) and Ala55Val (C > T) (rs660339) single nucleotide polymorphisms (SNPs) with obesity, high fasting plasma glucose, and serum lipids in a Balinese population. 22533685 2012
dbSNP: rs660339
rs660339
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
CUI: C0011849
Disease:
Diabetes Mellitus
0.050 GeneticVariation BEFREE Recently, our group reported that the -866A/55Val/Ins haplotype (-866G/A, Ala55Val and Ins/Del polymorphisms) of the UCP2 gene was associated with increased risk for DR in patients with DM. 22134120 2012