PSCA, prostate stem cell antigen, 8000

N. diseases: 111; N. variants: 14
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0013295
Disease:
Duodenal Ulcer
0.860 GeneticVariation BEFREE Cumulative evidence of an association was graded as strong for rs2294008 [odds ratio (OR) = 1.32, P = 5.1 × 10-33], rs2976392 (OR = 1.29, P = 1.8 × 10-8), rs9297976 (OR = 0.75, P = 1.4 × 10-7), rs2976391 (OR = 1.38, P = 6.1 × 10-5) and rs138377917 (OR = 0.53, P = 0.008) with gastric cancer, rs2294008 with bladder cancer (OR = 1.15, P = 8.0 × 10-19), gastritis (OR = 1.35, P = 1.2 × 10-5), duodenal ulcer (OR = 0.68, P = 2.4 × 10-57) and gastric ulcer (OR = 0.88, P = 1.7 × 10-7). 30407486 2019
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0013295
Disease:
Duodenal Ulcer
0.860 GeneticVariation BEFREE Our study confirms an association between the PSCA rs2294008 C-allele and the risk of DU in a Japanese population. 31839644 2019
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0013295
Disease:
Duodenal Ulcer
0.860 GeneticVariation BEFREE Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis. 27001215 2016
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0013295
Disease:
Duodenal Ulcer
0.860 GeneticVariation BEFREE Frequency of PSCA rs2294008 C/C genotype in duodenal ulcer was 36.1%, which was significantly higher than those with gastric cancer (12.4%), gastric ulcer (19.0%), gastritis (10.7%), and H. pylori-negatives (19.5%) (p < .001). 25582162 2015
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0013295
Disease:
Duodenal Ulcer
0.860 GeneticVariation BEFREE Genomic DNA from 603 Spanish patients with primary GC, 139 with DU and 675 healthy controls was typed for the PSCA rs2294008C>T polymorphism by PCR-TaqMan assays. 25721731 2015
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0013295
Disease:
Duodenal Ulcer
0.860 GeneticVariation BEFREE From these results we conclude that the PSCA rs2294008 polymorphism is involved in the susceptibility to GC and DU, as well as in the prognosis of the diffuse-type of GC in Caucasians. 25721731 2015
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0013295
Disease:
Duodenal Ulcer
0.860 GeneticVariation BEFREE The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)). 22387998 2012
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0013295
Disease:
Duodenal Ulcer
C 0.860 GeneticVariation GWASCAT The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)). 22387998 2012
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0013295
Disease:
Duodenal Ulcer
C 0.860 GeneticVariation GWASDB The T allele of rs2294008 encodes a translation initiation codon upstream of the reported site and changes protein localization from the cytoplasm to the cell surface. rs505922 at ABO was also associated with duodenal ulcer in a recessive model (OR = 1.32; P = 1.15 × 10(-10)). 22387998 2012
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0699791
Disease:
Stomach Carcinoma
0.800 GeneticVariation BEFREE Many epidemiological studies have identified the PSCA rs2294008 T-allele as a risk factor of GC, while others have found an association between the rs2294008 C-allele and risk of DU and gastric ulcer (GU). 31839644 2019
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0699885
Disease:
Carcinoma of bladder
0.800 GeneticVariation BEFREE Our meta-analysis supports that the PSCA gene variant rs2294008 polymorphism might contribute to individual susceptibility to bladder cancer. 31008939 2019
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0699791
Disease:
Stomach Carcinoma
0.800 GeneticVariation BEFREE We found that both rs2294008 (CT vs. CC, OR = 1.55, 95% CI = 1.20-1.99, <i>P</i><0.001 and CT+TT vs. CC, OR = 1.38, 95% CI = 1.09-1.74, <i>P</i>=0.008) and rs2976392 (GA vs. GG, OR = 1.61, 95% CI = 1.25-2.07, <i>P</i><0.001 and GA+AA vs. GG, OR = 1.52, 95% CI = 1.20-1.92, <i>P</i><0.001) were associated with an increased gastric cancer. 31416884 2019
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0699885
Disease:
Carcinoma of bladder
0.800 GeneticVariation BEFREE Cumulative evidence of an association was graded as strong for rs2294008 [odds ratio (OR) = 1.32, P = 5.1 × 10-33], rs2976392 (OR = 1.29, P = 1.8 × 10-8), rs9297976 (OR = 0.75, P = 1.4 × 10-7), rs2976391 (OR = 1.38, P = 6.1 × 10-5) and rs138377917 (OR = 0.53, P = 0.008) with gastric cancer, rs2294008 with bladder cancer (OR = 1.15, P = 8.0 × 10-19), gastritis (OR = 1.35, P = 1.2 × 10-5), duodenal ulcer (OR = 0.68, P = 2.4 × 10-57) and gastric ulcer (OR = 0.88, P = 1.7 × 10-7). 30407486 2019
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0005684
Disease:
Malignant neoplasm of urinary bladder
0.800 GeneticVariation BEFREE Our meta-analysis supports that the PSCA gene variant rs2294008 polymorphism might contribute to individual susceptibility to bladder cancer. 31008939 2019
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0005684
Disease:
Malignant neoplasm of urinary bladder
0.800 GeneticVariation BEFREE Cumulative evidence of an association was graded as strong for rs2294008 [odds ratio (OR) = 1.32, P = 5.1 × 10-33], rs2976392 (OR = 1.29, P = 1.8 × 10-8), rs9297976 (OR = 0.75, P = 1.4 × 10-7), rs2976391 (OR = 1.38, P = 6.1 × 10-5) and rs138377917 (OR = 0.53, P = 0.008) with gastric cancer, rs2294008 with bladder cancer (OR = 1.15, P = 8.0 × 10-19), gastritis (OR = 1.35, P = 1.2 × 10-5), duodenal ulcer (OR = 0.68, P = 2.4 × 10-57) and gastric ulcer (OR = 0.88, P = 1.7 × 10-7). 30407486 2019
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0699791
Disease:
Stomach Carcinoma
0.800 GeneticVariation BEFREE We conducted a case-control association study of <i>H. pylori</i>-infected gastritis and gastric cancer. rs2294008 was associated with the progression to chronic active gastritis (<i>P =</i> 9.4 × 10<sup>-5</sup>; odds ratio = 3.88, TT + TC vs CC genotype), but not with <i>H. pylori</i> infection <i>per se</i> nor with the progression from active gastritis to gastric cancer. 29423095 2018
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0699791
Disease:
Stomach Carcinoma
T 0.800 GeneticVariation GWASCAT Genome-wide association study identifies gastric cancer susceptibility loci at 12q24.11-12 and 20q11.21. 30281874 2018
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0699791
Disease:
Stomach Carcinoma
0.800 GeneticVariation BEFREE PSCA rs2294008/rs2976392 showed a significant, multiplicative interaction with H. pylori infection in risk of GC. 28220687 2017
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0005684
Disease:
Malignant neoplasm of urinary bladder
0.800 GeneticVariation BEFREE For the PSCA rs2294008 polymorphism, when stratified by type of cancer, the results were significant especially in gastric cancer and bladder cancer. 28881685 2017
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0699791
Disease:
Stomach Carcinoma
T 0.800 GeneticVariation GWASCAT Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies. 26701879 2017
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0699791
Disease:
Stomach Carcinoma
0.800 GeneticVariation BEFREE However, subtype-specific associations were observed for gastric cardia adenocarcinomas at MUC1/TRIM46/1q22 rs2070803 [HRAA versus GA+GG = 2.16; 95% confidence interval (CI) = 1.24-3.78; P = 0.0068] and LTA/TNF/6p21.33 rs1799724 (HRTT+CT versus CC = 1.30; 95% CI = 1.07-1.57; P = 0.0077), and for diffuse-type GC at PSCA/8q24.3 rs2294008 (HRTT versus CT+CC = 1.99; 95% CI = 1.33-2.97; P = 7.8E-04). 29028942 2017
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0699885
Disease:
Carcinoma of bladder
0.800 GeneticVariation BEFREE For the PSCA rs2294008 polymorphism, when stratified by type of cancer, the results were significant especially in gastric cancer and bladder cancer. 28881685 2017
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0699791
Disease:
Stomach Carcinoma
0.800 GeneticVariation BEFREE Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis. 27001215 2016
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0699791
Disease:
Stomach Carcinoma
0.800 GeneticVariation BEFREE In conclusion, the results indicated that the PSCA rs2294008 T and rs2976392 A alleles were low-penetrate risk factors for GCa in this study population. 26848528 2016
dbSNP: rs2294008
rs2294008
Entrez Id: 8000;8629
Gene Symbol: PSCA;JRK
PSCA;JRK
CUI: C0005684
Disease:
Malignant neoplasm of urinary bladder
0.800 GeneticVariation BEFREE Based on the statistical evidence, we can draw a conclusion that the rs2294008 polymorphism of PSCA gene is likely to play a role in cancer carcinogenesis, especially in gastric cancer and bladder cancer. 26308216 2015