CASP8, caspase 8, 841

N. diseases: 480; N. variants: 32
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3769825
rs3769825
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0023434
Disease:
Chronic Lymphocytic Leukemia 		T 0.800 GeneticVariation GWASDB Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. 23770605 2013
dbSNP: rs3769825
rs3769825
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0023434
Disease:
Chronic Lymphocytic Leukemia 		T 0.800 GeneticVariation GWASCAT Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. 23770605 2013
dbSNP: rs17860424
rs17860424
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C1846545
Disease:
Autoimmune Lymphoproliferative Syndrome Type 2B 		T 0.800 CausalMutation CLINVAR
dbSNP: rs17860424
rs17860424
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C1846545
Disease:
Autoimmune Lymphoproliferative Syndrome Type 2B 		0.800 GeneticVariation UNIPROT
dbSNP: rs3769821
rs3769821
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0678222
Disease:
Breast Carcinoma 		0.710 GeneticVariation BEFREE Also, the C allele of rs3769821 was associated with a 43% increased risk of breast cancer (P = 0.005); however, after adjustment for confounding factors, no association with rs3769821 and breast cancer was observed. 31257627 2019
dbSNP: rs10931936
rs10931936
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0014859
Disease:
Esophageal Neoplasms 		0.710 GeneticVariation BEFREE Four of the 20 SNPs identified as high-risk SNPs in Chinese esophageal cancer showed increased risk for Chinese lung cancer, which included rs3769823 (OR = 1.26; 95% CI = 1.107-1.509; P = 0.02), rs10931936 (OR = 1.283; 95% CI = 1.100-1.495; P = 0.04), rs2244438 (OR = 1.294; 95% CI = 1.098-1.525; P = 0.04) and rs13016963 (OR = 1.268; 95% CI = 1.089-1.447; P = 0.04). 28542283 2017
dbSNP: rs3769821
rs3769821
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0678222
Disease:
Breast Carcinoma 		T 0.710 GeneticVariation GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
dbSNP: rs10931936
rs10931936
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0014859
Disease:
Esophageal Neoplasms 		0.710 GeneticVariation GWASDB Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies. 22323360 2012
dbSNP: rs10931933
rs10931933
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0023508
Disease:
White Blood Cell Count procedure 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs3769821
rs3769821
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		C 0.700 GeneticVariation GWASCAT Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations. 31326317 2019
dbSNP: rs59308963
rs59308963
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0600139
Disease:
Prostate carcinoma 		T 0.700 GeneticVariation GWASCAT Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci. 29892016 2018
dbSNP: rs3769823
rs3769823
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0007117
Disease:
Basal cell carcinoma 		A 0.700 GeneticVariation GWASCAT Association between genetic variation within vitamin D receptor-DNA binding sites and risk of basal cell carcinoma. 28177523 2017
dbSNP: rs3769823
rs3769823
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0206710
Disease:
Basal Cell Neoplasm 		A 0.700 GeneticVariation GWASCAT Association between genetic variation within vitamin D receptor-DNA binding sites and risk of basal cell carcinoma. 28177523 2017
dbSNP: rs3769823
rs3769823
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0751676
Disease:
Basal Cell Cancer 		A 0.700 GeneticVariation GWASCAT Association between genetic variation within vitamin D receptor-DNA binding sites and risk of basal cell carcinoma. 28177523 2017
dbSNP: rs3769823
rs3769823
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0202236
Disease:
Triglycerides measurement 		G 0.700 GeneticVariation GWASCAT Exome-wide association study of plasma lipids in >300,000 individuals. 29083408 2017
dbSNP: rs6735656
rs6735656
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0200635
Disease:
Lymphocyte Count measurement 		T 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs3769825
rs3769825
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0855095
Disease:
Small Lymphocytic Lymphoma 		T 0.700 GeneticVariation GWASCAT Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia. 23770605 2013
dbSNP: rs10931936
rs10931936
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0025202
Disease:
melanoma 		0.700 GeneticVariation GWASDB Genome-wide association study identifies three new melanoma susceptibility loci. 21983787 2011
dbSNP: rs587776665
rs587776665
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C2239176
Disease:
Liver carcinoma 		C 0.700 CausalMutation CLINVAR
dbSNP: rs1045485
rs1045485
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0678222
Disease:
Breast Carcinoma 		0.100 GeneticVariation BEFREE Association of caspase 8 polymorphisms -652 6N InsDel and Asp302His with progression-free survival and tumor infiltrating lymphocytes in early breast cancer. 31467295 2019
dbSNP: rs1045485
rs1045485
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.100 GeneticVariation BEFREE Our data showed a protective effect for CC genotype of rs1045485 variant and C-C haplotype of rs10931936-rs104548 in CASP8 in association with the decrease risk of breast cancer whereas rs10931936 showed no significant association. 31362911 2019
dbSNP: rs1045485
rs1045485
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.100 GeneticVariation BEFREE Association of caspase 8 polymorphisms -652 6N InsDel and Asp302His with progression-free survival and tumor infiltrating lymphocytes in early breast cancer. 31467295 2019
dbSNP: rs1045485
rs1045485
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0678222
Disease:
Breast Carcinoma 		0.100 GeneticVariation BEFREE Our data showed a protective effect for CC genotype of rs1045485 variant and C-C haplotype of rs10931936-rs104548 in CASP8 in association with the decrease risk of breast cancer whereas rs10931936 showed no significant association. 31362911 2019
dbSNP: rs1045485
rs1045485
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.100 GeneticVariation BEFREE Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer. 27507139 2016
dbSNP: rs1045485
rs1045485
Entrez Id: 841
Gene Symbol: CASP8
CASP8
CUI: C0678222
Disease:
Breast Carcinoma 		0.100 GeneticVariation BEFREE Prognostic relevance of caspase 8 -652 6N InsDel and Asp302His polymorphisms for breast cancer. 27507139 2016