IL1RL1, interleukin 1 receptor like 1, 9173

N. diseases: 117; N. variants: 51
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3771180
rs3771180
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
0.820 GeneticVariation BEFREE Association of IL1RL1 rs3771180 and TSLP rs1837253 variants with asthma in the Guangxi Zhuang population in China. 31066119 2019
dbSNP: rs3771180
rs3771180
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
T 0.820 GeneticVariation GWASCAT Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. 29273806 2018
dbSNP: rs3771180
rs3771180
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
0.820 GeneticVariation BEFREE We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus. 23028483 2012
dbSNP: rs3771180
rs3771180
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
0.820 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549 2011
dbSNP: rs3771180
rs3771180
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
0.820 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549 2011
dbSNP: rs10197862
rs10197862
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
A 0.810 GeneticVariation GWASCAT Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. 24388013 2014
dbSNP: rs13408661
rs13408661
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
G 0.810 GeneticVariation GWASCAT We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus. 23028483 2012
dbSNP: rs13408661
rs13408661
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
G 0.810 GeneticVariation GWASDB We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus. 23028483 2012
dbSNP: rs13408661
rs13408661
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
0.810 GeneticVariation BEFREE We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus. 23028483 2012
dbSNP: rs10197862
rs10197862
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
0.810 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549 2011
dbSNP: rs10197862
rs10197862
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
0.810 GeneticVariation BEFREE However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01). 21150878 2011
dbSNP: rs13408661
rs13408661
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
0.810 GeneticVariation GWASDB Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. 21804549 2011
dbSNP: rs950881
rs950881
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1527304
Disease:
Allergic Reaction
0.800 GeneticVariation GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016
dbSNP: rs950881
rs950881
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C1527304
Disease:
Allergic Reaction
T 0.800 GeneticVariation GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0200638
Disease:
Eosinophil count procedure
A 0.800 GeneticVariation GWASCAT Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. 19198610 2009
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0200638
Disease:
Eosinophil count procedure
A 0.800 GeneticVariation GWASDB Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. 19198610 2009
dbSNP: rs10192157
rs10192157
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
0.710 GeneticVariation BEFREE However, the rs10192157 and rs2899642 mutations were documented with asthma disease. 31213409 2020
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
T 0.710 GeneticVariation GWASCAT Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults. 30578877 2019
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0027430
Disease:
Nasal Polyps
T 0.710 GeneticVariation GWASCAT A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 30643255 2019
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
T 0.710 GeneticVariation GWASCAT Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. 29273806 2018
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
0.710 GeneticVariation BEFREE Finally, we determined the association of IL1RL1-a levels with asthma and its clinical characteristics (n=1101).<i>IL1RL1</i> asthma-risk SNPs strongly associated with <i>IL1RL1</i> methylation (rs1420101; p=3.7×10<sup>-16</sup>) and serum IL1RL1-a levels (p=2.8×10<sup>-56</sup>). 29519908 2018
dbSNP: rs10192157
rs10192157
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
0.710 GeneticVariation GWASDB A large-scale, consortium-based genomewide association study of asthma. 20860503 2010
dbSNP: rs1420101
rs1420101
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0027430
Disease:
Nasal Polyps
0.710 GeneticVariation BEFREE Although rs1420101 itself failed to associate with NP, a combined risk assessment of rs3939286 and rs1420101 further increased the risk for NP. 19860791 2010
dbSNP: rs10208293
rs10208293
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0004096
Disease:
Asthma
G 0.700 GeneticVariation GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433 2019
dbSNP: rs10208293
rs10208293
Entrez Id: 8809;9173
Gene Symbol: IL18R1;IL1RL1
IL18R1;IL1RL1
CUI: C0264408
Disease:
Childhood asthma
G 0.700 GeneticVariation GWASCAT Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies. 31036433 2019