TNFSF15, TNF superfamily member 15, 9966

N. diseases: 143; N. variants: 11
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3810936
rs3810936
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.850 GeneticVariation BEFREE For example, we characterized that the Crohn's disease risk variant for rs3810936 increases NFKB1 binding and results in altered gene expression. 30254052 2018
dbSNP: rs3810936
rs3810936
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.850 GeneticVariation BEFREE Our analysis suggested that rs3810936 polymorphism was significantly associated with decreased risk of Crohn's disease (CD) and ulcerative colitis (UC). 29873318 2018
dbSNP: rs3810936
rs3810936
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.850 GeneticVariation BEFREE Our results confirmed a significant association of CD with the following previously reported risk loci: rs3810936 in TNFSF15 (OR=1.83, p<2.2×10(-16)), rs76418789 in IL23R (OR=0.47, p=1.14×10(-8)) and rs2241880 in ATG16L1 (OR=1.30, p=5.28×10(-6)). 25731871 2016
dbSNP: rs3810936
rs3810936
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.850 GeneticVariation BEFREE The minor T alleles and the TT genotypes of rs10114470 and rs3810936 were significantly protectively associated with both CD and UC. 25501099 2014
dbSNP: rs3810936
rs3810936
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.850 GeneticVariation BEFREE According to the subgroup analysis by ethnicity, except for rs4263839 in Caucasian and rs4979462 in Asian, all the rest investigated TNFSF15 polymorphisms were associated with CD risk and rs3810936 and rs7848647 polymorphism in Asian as well as rs6478108 polymorphism in Caucasian were associated with UC risk. 25028192 2014
dbSNP: rs3810936
rs3810936
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
C 0.850 GeneticVariation GWASDB Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463 2010
dbSNP: rs3810936
rs3810936
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
C 0.850 GeneticVariation GWASCAT Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. 21102463 2010
dbSNP: rs3810936
rs3810936
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.850 GeneticVariation GWASDB Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. 16221758 2005
dbSNP: rs7848647
rs7848647
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.840 GeneticVariation BEFREE For rs7848647 polymorphism, significantly protective association between this polymorphism and CD risk was also observed, but not in UC. 29873318 2018
dbSNP: rs7848647
rs7848647
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.840 GeneticVariation GWASCAT Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci. 26974007 2016
dbSNP: rs7848647
rs7848647
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.840 GeneticVariation BEFREE The CC genotype of rs6478108, AA genotype of rs4263839, the AA genotype of rs6478109, the TT genotype of rs7848647 and the CC genotype of rs7869487 were all protectively associated with CD but not with UC. 25501099 2014
dbSNP: rs7848647
rs7848647
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.840 GeneticVariation BEFREE According to the subgroup analysis by ethnicity, except for rs4263839 in Caucasian and rs4979462 in Asian, all the rest investigated TNFSF15 polymorphisms were associated with CD risk and rs3810936 and rs7848647 polymorphism in Asian as well as rs6478108 polymorphism in Caucasian were associated with UC risk. 25028192 2014
dbSNP: rs7848647
rs7848647
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.840 GeneticVariation BEFREE Carriers of three polymorphisms, including rs3810936, rs6478108, and rs7848647, showed statistically significant association with CD (adjusted OR [aOR] 2.81, 95% confidence interval [CI] 1.94-4.07, P= 4.4 x 10(-8); aOR 3.49, 95% CI 2.42-5.04, P= 2.7 x 10(-11); and aOR 3.49, 95% CI 2.42-5.03, P= 2.2 x 10(-11), respectively). 18422820 2008
dbSNP: rs7848647
rs7848647
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.840 GeneticVariation GWASDB Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. 16221758 2005
dbSNP: rs4979462
rs4979462
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0008312
Disease:
Primary biliary cirrhosis
0.830 GeneticVariation GWASCAT POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33. 30643196 2019
dbSNP: rs4979462
rs4979462
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0008312
Disease:
Primary biliary cirrhosis
0.830 GeneticVariation BEFREE A previous genome-wide association study (GWAS) performed in 963 Japanese individuals (487 primary biliary cholangitis [PBC] cases and 476 healthy controls) identified TNFSF15 (rs4979462) and POU2AF1 (rs4938534) as strong susceptibility loci for PBC. 28062665 2017
dbSNP: rs4979462
rs4979462
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0008312
Disease:
Primary biliary cirrhosis
C 0.830 GeneticVariation GWASCAT A previous genome-wide association study (GWAS) performed in 963 Japanese individuals (487 primary biliary cholangitis [PBC] cases and 476 healthy controls) identified TNFSF15 (rs4979462) and POU2AF1 (rs4938534) as strong susceptibility loci for PBC. 28062665 2017
dbSNP: rs4979462
rs4979462
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0008312
Disease:
Primary biliary cirrhosis
0.830 GeneticVariation BEFREE Using genetic data from published studies on CD, PBC and leprosy we revealed that bearing a T allele at rs6478108/rs6478109 (r(2) = 1) or rs4979462 was significantly associated with increased risk of CD and decreased risk of leprosy, while the T allele at rs4979462 was associated with significantly increased risk of PBC. 27507062 2016
dbSNP: rs6478109
rs6478109
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
G 0.830 GeneticVariation GWASCAT HLA-C*01 is a Risk Factor for Crohn's Disease. 26891255 2016
dbSNP: rs6478109
rs6478109
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.830 GeneticVariation BEFREE Using genetic data from published studies on CD, PBC and leprosy we revealed that bearing a T allele at rs6478108/rs6478109 (r(2) = 1) or rs4979462 was significantly associated with increased risk of CD and decreased risk of leprosy, while the T allele at rs4979462 was associated with significantly increased risk of PBC. 27507062 2016
dbSNP: rs4979462
rs4979462
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0008312
Disease:
Primary biliary cirrhosis
0.830 GeneticVariation BEFREE Moreover, higher endogenous TNFSF15 protein and mRNA expression levels were observed in individuals with the PBC-susceptible allele of rs4979462. 25899471 2015
dbSNP: rs4263839
rs4263839
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.830 GeneticVariation BEFREE Among the TNFSF15 SNPs, rs4263839 associated with CD in Taiwan (P = 0.005), haplotype analysis did not increase the association. 24783249 2014
dbSNP: rs4263839
rs4263839
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.830 GeneticVariation BEFREE This meta-analysis indicated that most of the seven TNFSF15 polymorphisms (except for rs4263839) were risk factors contributed to CD and UC susceptibility. 25028192 2014
dbSNP: rs6478109
rs6478109
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.830 GeneticVariation BEFREE Except for rs4263839 polymorphism, significant associations were found between the rest six TNFSF15 polymorphisms and CD risk (rs3810936: OR = 2.10, 95% CI, 1.47-3.00; rs6478108: OR = 2.19, 95% CI, 1.53-3.13; rs4979462: OR = 1.89, 95% CI, 1.42-2.52; rs6478109: OR = 2.00, 95% CI, 1.39-2.88; rs7848647: OR = 1.54, 95% CI, 1.15-2.06; rs7869487: OR = 1.51, 95% CI, 1.06-2.17). 25028192 2014
dbSNP: rs6478109
rs6478109
Entrez Id: 9966
Gene Symbol: TNFSF15
TNFSF15
CUI: C0010346
Disease:
Crohn Disease
0.830 GeneticVariation BEFREE The CC genotype of rs6478108, AA genotype of rs4263839, the AA genotype of rs6478109, the TT genotype of rs7848647 and the CC genotype of rs7869487 were all protectively associated with CD but not with UC. 25501099 2014