|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
CACNA1C-rs1006737 and ZNF804A-rs1344706 polymorphisms are among the most robustly associated with schizophrenia (SCZ) and bipolar disorder (BD), and recently with brain phenotypes.
|
30079586 |
2019 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Both CACNA1C (rs1006737) and KCNH2 (rs3800779) were genotyped in 101 controls and 50 schizophrenia patients.
|
30607529 |
2019 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We performed a comprehensive meta-analysis of all available samples from existing studies under four different genetic models (recessive model, dominant model, additive model and allele model) to further confirm whether CACNA1C rs1006737 is an authentic risk single nucleotide polymorphism (SNP) for schizophrenia.
|
31033230 |
2019 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data suggests a minor involvement of CACNA1C rs1006737 in psychosis via conferring susceptibility to white matter microstructural abnormalities in SZ.
|
27790829 |
2017 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Specifically, genome wide association studies (GWAS) have repeatedly identified the single nucleotide polymorphism (SNP) rs1006737 in intron 3 of CACNA1C to be strongly associated with schizophrenia and bipolar disorder.
|
27276213 |
2016 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism at rs1006737 in CACNA1C has been associated with both schizophrenia and bipolar disorder and with several intermediate phenotypes that may serve as neurobiological antecedents, linking psychosis to genetic aetiology.
|
26048451 |
2016 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results further confirmed that rs1006737 should be categorized as an authentic risk SNP for schizophrenia in the general populations.
|
25588813 |
2015 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Nine teams, including four European decent samples and five Asian samples, contributed 14,141 cases and 30,679 controls for the analysis of CACNA1C rs1006737 and SZ.
|
26227746 |
2015 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings further support a role for the CACNA1C gene, particularly for the rs1006737, in SCZ.
|
26049408 |
2015 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
CACNA1C risk variant rs1006737 affects cortical white matter integrity in schizophrenia.
|
25470093 |
2014 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found that rs1006737 was associated with both schizophrenia (P(allele) = 0.0014, P(genotype) = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134-1.690) and major depressive disorder (P(allele) = 0.0007, P(genotype) = 0.003, OR = 1.425, 95% CI 1.160-1.752).
|
24262814 |
2014 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results provide further support for associations of rs1006737</span> and rs1024582 with schizophrenia, identify a new risk locus rs2007044 in a Han Chinese population, and further establish CACNA1C as an important susceptibility gene for the disease across world populations.
|
24355530 |
2014 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Further analysis of the haplotype rs1006737-rs4765905-rs882194 in CACNA1C showed significant associations with schizophrenia (corrected global p<0.005), and two haplotypes (ACC and ACT) in the block were significantly increased in the patients.
|
24275578 |
2014 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
|
24280982 |
2014 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The variant at rs1006737 in the L-type voltage-gated calcium channel (alpha 1c subunit) CACNA1C gene is reliably associated with both bipolar disorder and schizophrenia.
|
25290268 |
2014 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
On the other hand, our results indicate that alterations in the functional coupling between the prefrontal cortex and the medial temporal lobe could represent a neural system phenotype that is mediated by CACNA1C rs1006737 and other genetic susceptibility loci for schizophrenia and bipolar disorder.
|
23404764 |
2014 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We combined genotyping of SNP rs1006737 in CACNA1C with structural MRI measurements of relative gray matter (GM) amygdala volume in patients with SZ, BD or OCD as well as healthy controls (N Total = 72).
|
23880959 |
2014 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The study population comprised 188 healthy first-degree relatives of patients with bipolar disorder (n=59), major depression (n=73), and schizophrenia (n=56) and 110 comparison subjects from our discovery study who were genotyped for rs1006737 and underwent functional magnetic resonance imaging while performing an episodic memory task and psychological testing.
|
24411473 |
2014 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genome-wide association studies have reported an association between the A-allele of rs1006737 within CACNA1C and affective disorders and schizophrenia.
|
22665259 |
2013 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
|
23974872 |
2013 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Several genetic studies have implicated the CACNA1C SNP rs1006737 in bipolar disorder (BD) and schizophrenia (SZ) pathology.
|
23437284 |
2013 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
|
23453885 |
2013 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
|
23974872 |
2013 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
These results add to the literature suggesting that rs1006737 may be associated with schizophrenia through its detrimental effect on endophenotypic traits.
|
22957138 |
2012 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
CACNA1C gene polymorphism (rs1006737) is a susceptibility factor for both schizophrenia (SCZ) and bipolar disorder (BP).
|
22012475 |
2012 |