|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
CACNA1C-rs1006737 and ZNF804A-rs1344706 polymorphisms are among the most robustly associated with schizophrenia (SCZ) and bipolar disorder (BD), and recently with brain phenotypes.
|
30079586 |
2019 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Both CACNA1C (rs1006737) and KCNH2 (rs3800779) were genotyped in 101 controls and 50 schizophrenia patients.
|
30607529 |
2019 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We performed a comprehensive meta-analysis of all available samples from existing studies under four different genetic models (recessive model, dominant model, additive model and allele model) to further confirm whether CACNA1C rs1006737 is an authentic risk single nucleotide polymorphism (SNP) for schizophrenia.
|
31033230 |
2019 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
CACNA1C-rs1006737 and ZNF804A-rs1344706 polymorphisms are among the most robustly associated with schizophrenia (SCZ) and bipolar disorder (BD), and recently with brain phenotypes.
|
30079586 |
2019 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genotyping results indicated that rs1006737 in CACNA1C was significantly associated with BD, while rs10994336 or rs9804190 in ANK3 was not significant when examined individually.
|
29684488 |
2018 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genome-wide studies have identified allele A (adenine) of single nucleotide polymorphism (SNP) rs1006737 of the calcium-channel CACNA1C gene as a risk factor for both schizophrenia (SZ) and bipolar disorder (BD) as well as allele A for rs1344706 in the ZNF804A gene.
|
27790829 |
2017 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our data suggests a minor involvement of CACNA1C rs1006737 in psychosis via conferring susceptibility to white matter microstructural abnormalities in SZ.
|
27790829 |
2017 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
One hundred seventeen euthymic BD type I subjects were genotyped for CACNA1C rs1006737 and underwent 3 T three-dimensional structural magnetic resonance imaging scans to determine cortical thickness of mPFC components (superior frontal cortex (sFC), medial orbitofrontal cortex (mOFC), caudal anterior cingulate cortex (cACC) and rostral anterior cingulate cortex (rACC)).
|
28398341 |
2017 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Specifically, genome wide association studies (GWAS) have repeatedly identified the single nucleotide polymorphism (SNP) rs1006737 in intron 3 of CACNA1C to be strongly associated with schizophrenia and bipolar disorder.
|
27276213 |
2016 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Specifically, genome wide association studies (GWAS) have repeatedly identified the single nucleotide polymorphism (SNP) rs1006737 in intron 3 of CACNA1C to be strongly associated with schizophrenia and bipolar disorder.
|
27276213 |
2016 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our study further supports the association of SNP rs1006737 with BD-I and suggests that CACNA1C SNP rs1006737 and Bcl-2 SNP rs956572, or specific causal variants in LD with these proxies, act independently to increase risk and ICDH in BD-I.
|
25843436 |
2016 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism at rs1006737 in CACNA1C has been associated with both schizophrenia and bipolar disorder and with several intermediate phenotypes that may serve as neurobiological antecedents, linking psychosis to genetic aetiology.
|
26048451 |
2016 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
Though rs1006737 in the CACNA1C gene showed significant association with MDD in a British large-scale candidate association study, most of the replication analyses with relatively small sample size reported negative association.
|
27260792 |
2016 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found a significant association between the risk allele in rs1006737 and a decreased CSF hyperphosphorylated tau/total tau ratio in patients with bipolar disorder, thus linking variation in the CACNA1C gene to a neurochemical marker of neuroaxonal plasticity in those with this disorder.
|
26541689 |
2016 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism at rs1006737 in CACNA1C has been associated with both schizophrenia and bipolar disorder and with several intermediate phenotypes that may serve as neurobiological antecedents, linking psychosis to genetic aetiology.
|
26048451 |
2016 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results further confirmed that rs1006737 should be categorized as an authentic risk SNP for schizophrenia in the general populations.
|
25588813 |
2015 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Nine teams, including four European decent samples and five Asian samples, contributed 14,141 cases and 30,679 controls for the analysis of CACNA1C rs1006737 and SZ.
|
26227746 |
2015 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our findings further support a role for the CACNA1C gene, particularly for the rs1006737, in SCZ.
|
26049408 |
2015 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
CACNA1C rs1006737 genotype and bipolar disorder: Focus on intermediate phenotypes and cardiovascular comorbidity.
|
25976633 |
2015 |
|
Major Depressive Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found that rs1006737 was associated with both schizophrenia (P(allele) = 0.0014, P(genotype) = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134-1.690) and major depressive disorder (P(allele) = 0.0007, P(genotype) = 0.003, OR = 1.425, 95% CI 1.160-1.752).
|
24262814 |
2014 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
This is most interesting because the common single-nucleotide polymorphism (SNP) most highly associated with BD is rs1006737, which we show here is a cis-expression quantitative trait locus for CACNA1C in human cerebellum, and the risk allele (A) is associated with decreased expression.
|
23979604 |
2014 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
CACNA1C risk variant rs1006737 affects cortical white matter integrity in schizophrenia.
|
25470093 |
2014 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
BEFREE |
On the other hand, our results indicate that alterations in the functional coupling between the prefrontal cortex and the medial temporal lobe could represent a neural system phenotype that is mediated by CACNA1C rs1006737 and other genetic susceptibility loci for schizophrenia and bipolar disorder.
|
23404764 |
2014 |
|
Bipolar Disorder
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
|
24280982 |
2014 |
|
Schizophrenia
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found that rs1006737 was associated with both schizophrenia (P(allele) = 0.0014, P(genotype) = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134-1.690) and major depressive disorder (P(allele) = 0.0007, P(genotype) = 0.003, OR = 1.425, 95% CI 1.160-1.752).
|
24262814 |
2014 |