rs1042713, ADRB2

N. diseases: 63
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Obesity risk was significantly associated to 6 SNPs (ADRB2 rs1042713, APOB rs512535, PPARA rs1800206, TNFA rs361525, TRHR rs7832552 and rs16892496) after adjustment by gender, age, ancestry, VO<sub>2max</sub> , and ME. 28294290 2017
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE However, our results do not support an association between rs1042713 (Arg16Gly) polymorphisms and obesity in the populations investigated. 24960039 2014
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE On the other hand, hypertensive cases, whether being isolated or associated with obesity and/or diabetes, showed a nonsignificant difference from controls in relation to all genotypic variants related to the ADRB2 G46A polymorphism (p>0.05). 22731644 2012
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE CART analysis showed that smoking parents who overate and carried the Arg allele, ADRB2 R16G, had an odds ratio (OR) of 11.7 (95% confidence interval (CI), 2.13-64.04) for obesity compared to non-smoking parents who had none of these factors. 22094842 2011
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Stratification analyses by obesity showed that A46G polymorphism was related to the prevalence of hypertension in the obese population (GG vs. AG vs. AA, P<0.001, OR = 1.645, 95%CI [1.258-2.151]). 21483652 2011
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Although each polymorphism of β3AR Trp64Arg, β2AR Arg16Gly and UCP1 -3826A>G is known to be associated with obesity, the interaction among these polymorphisms is not fully understood. 21959333 2011
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Together, our findings suggest evidence for a two-locus interaction between the LEPR Gln223Arg and ADRB2 Arg16Gly variants in the risk of overweight/obesity, and highlight further the importance of multilocus effects in the genetic component of obesity. 21233811 2011
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE β2-adrenoceptor (β2AR) gene polymorphism glutamine 27 glutamic acid (Gln27Glu) and Arg16Gly were reported to have an association with obesity and obesity related disorders in some population. 20738880 2010
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Proposed test statistics are applied to NHANES III data to test for associations between the locus ADRB2 (rs1042713) and obesity, between VDR (rs2239185) and high blood lead level, and between TGFB1 (rs1982073) and asthma. 19745160 2010
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The summary odds ratio (OR) from overall analyses showed no association between either rs1042714 or rs1042713 and obesity. 19186333 2008
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Several case-control studies have explored the possible association between polymorphism in the beta2 adrenoreceptor gene (beta2AR), hypertension, and obesity--the focus being in particular on the Arg16Gly and Gln27Glu substitutions, which appear to modify the extracellular part of the beta2AR with possible functional modification. 15323067 2004
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Additionally, for the polymorphic sites of BAR-2 (Arg16Gly and Gln27Glu) a significant effect on obesity risk was seen. 12395215 2002
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE The Arg16Gly genotype showed significant relationships to elevated central distribution of body fat and to systolic blood pressure, whilst the Glu27Glu genotype was associated with elevated leptin and triglyceride levels but not to other measurements, including obesity variables. 10971791 2000
Obesity
CUI: C0028754
Disease: Obesity
0.100 GeneticVariation BEFREE Our results suggest that the Gln27Glu and Arg16Gly polymorphisms of the beta2AR gene are not a major contributing factor to obesity in Japanese men. 11016907 2000