Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Congestive heart failure
CUI: C0018802
Disease: Congestive heart failure
0.040 GeneticVariation BEFREE There was no difference in the prevalence of polymorphism Gln27Glu between HF patients and control subjects. 28933308 2018
Congestive heart failure
CUI: C0018802
Disease: Congestive heart failure
0.040 GeneticVariation BEFREE We investigated whether a predefined combination of the Arg389Gly polymorphism in the adrenergic β(1) -receptor gene (ADRB1) and the Gln27Glu polymorphism in the adrenergic β(2) -receptor gene (ADRB2) could predict survival in carvedilol- and metoprolol-treated chronic heart failure (HF) patients. 21395649 2011
Congestive heart failure
CUI: C0018802
Disease: Congestive heart failure
0.040 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) within the β(1)- (Ser49Gly, Arg389Gly) and β(2)-adrenoceptor (Arg16Gly, Gln27Glu, Thr164Ile) have been associated with alterations in adrenoceptor (AR) function sensitivity in vitro and in vivo and possibly contribute to HF progression. 20803192 2010
Congestive heart failure
CUI: C0018802
Disease: Congestive heart failure
0.040 GeneticVariation BEFREE We investigated the clinical response of chronic heart failure patients with beta(2)-adrenergic receptor Gln(27)-->Glu polymorphism treated for 6 months with carvedilol, a alpha/beta-antagonist with antioxidant properties.The 6-min. walk test, the left ventricular ejection fraction, heart rate, plasma norepinephrine and malondialdehyde, a stress oxidative marker, concentrations were evaluated at baseline and after treatment for 6 months with carvedilol in 33 stable chronic heart failure patients with the Gln(27)-->Glubeta(2)-adrenergic receptor polymorphism. 19422106 2009