|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Expression of the C7</span>9G polymorphism of the ADRB2 gene was significantly associated with risk of pediatric asthma associated with the C or G allele with comparison of the co-dominant model (GG vs. CC: OR, 0.69; 95% CI, 0.55-0.88) and the recessive model (GG vs. CC+CG: OR, 0.65; 95% CI, 0.53-0.81).
|
31142730 |
2019 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the age stratification analysis, C79G polymorphism owned a reduced effect on asth</span>ma risk for children (GG vs. CC: OR=0.69, p=0.002; GG vs. CC+CG: OR=0.65, p<0.001).
|
31115019 |
2019 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings show that the risk of development of asthma or response to treatment can be, respectively, deciphered by the detection of both rs1042713 and rs1042714 variants in <i>ADRB2</i> gene.
|
30468638 |
2019 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis suggests that the ADRB2 rs1042714 polymorphism has a protective association with asthma in the overall population and the pediatric subgroup.
|
31699066 |
2019 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The findings suggest that the Arg16Gly and Gln27Glu polymorphisms in the β2-AR gene are associated with asthma severity and response to therapy and might be used in personalized treatment for these patients in the future.
|
30178312 |
2018 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
A total of 107 unrelated overweight/obese individuals were genotyped for two ADRB2 non-synonymous polymorphisms: Arg16Gly (rs1042713) and Gln27Glu (rs1042714).
|
29331538 |
2018 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among 29 candidate single-nucleotide polymorphisms, rs7897633-A in PRKG1, rs434082-A in SLC8A1 and rs1042714-G in ADRB2 were significantly associated with salt-sensitive hypertension.
|
28446801 |
2017 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Gender is an effect modifier for the effect of the rs1042714 polymorphism on obesity-related traits in Malaysian Malays.
|
22199155 |
2015 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Arg16Gly and Gln27Glu polymorphisms do not determine the occurrence of asthma individually, but the GG-CG haplotype is associated with an increased risk of asthma.
|
25985706 |
2015 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study indicates that the ADRB2 rs1042714 SNP may contribute to the risk of obesity and predict obesity-related metabolic traits such as BMI, triglyceride, and systolic blood pressure in Taiwanese subjects.
|
24322328 |
2014 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis revealed that the rs1042714 (Gln27Glu) polymorphism is associated with obesity susceptibility.
|
24960039 |
2014 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In Serbian adults, carriers of the 27Gln allele and 27Gln/Gln genotype were at higher risk of asthma [odds ratio (OR) 2.5, 95% confidence interval (CI) 1.6-3.8, and OR 3.00, 95% CI 1.7-5.3, respectively], while the presence of the 27Glu allele and 27Gln/Glu genotype were found to be protective of asthma (OR 0.4, 95% CI 0.3-0.6, and OR 0.3, 95% CI 0.1-0.7, respectively).
|
25074500 |
2014 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Gln/Glu27 polymorphism might be a contributor to asthma susceptibility for adults.
|
24992184 |
2014 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Therefore, the Gln27Glu polymorphism of the β2 adrenoceptor could be a risk factor associated with hypertension among Malaysians.
|
24782128 |
2014 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that in the group of mestizo schoolchildren studied, the Arg16Gly and Gln27Glu polymorphisms are not markers of susceptibility or severity of asthma and do not affect ADRB2 gene expression during the rescue therapy.
|
22328447 |
2012 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this study, we performed a meta-analysis to assess the associations of 46A/G and 79C/G polymorphisms in β2-AR gene with hypertension risk in Han Chinese population.
|
22763735 |
2012 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Furthermore, Gly16Arg (rs1042713) and Gln27Glu (rs1042714) in the ADRB2 gene were not associated with blood pressure, hypertension or CVD either in the population overall or in women and men separately.
|
21883537 |
2012 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We tested the hypothesis that three functional polymorphisms in the ADRB2 gene (Thr164Ile, Gly16Arg and Gln27Glu) are associated with reduced lung function, asthma or chronic obstructive pulmonary disease (COPD).
|
22075484 |
2012 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We evaluated Gln27Glu polymorphism in the β2AR gene in obese Saudi populations to investigate the association of β2AR gene with obesity</span> and other related metabolic parameters.
|
20738880 |
2010 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
As Black Americans have an increased risk of hypertension, we evaluated associations between beta(1)-AR (Arg389Gly) and beta(2)-AR (Arg16Gly, Gln27Glu) gene variants and cardiovascular reactivity in 500 Black youth.
|
20374546 |
2010 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
No overall statistical association could be found between C79G and hypertension risk or any ethnic subgroup.
|
20739939 |
2010 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The authors analyze the possible implication of 7 genetic polymorphisms described as asthma susceptibility genes: IL13 (C-1112T and R130Q), IL4RA (I50V, Q551R), IL5 (C-746T) and ADRB2 (Q27E and R16G) in specific olive pollen allergic sensitization.
|
18849614 |
2009 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Eleven single nucleotide polymorphisms (SNPs) in CHRM1-3 (coding muscarinic receptors one to three) which were identified by re-sequencing, and Arg16Gly and Gln27Glu in ADRB2 (coding beta(2) adrenoreceptor) were scored in 80 of the 138 asthmatics.
|
19183167 |
2009 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ADRbeta2 variations Gly(16)Arg and Gln(27)Glu and, more recently, haplotypic variations, have been the focus of numerous pharmacogenetic studies looking at responses to short-acting (SABA) and long-acting beta-agonists (LABA) in subjects with asthma.
|
18303970 |
2008 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The summary odds ratio (OR) from overall analyses showed no association between either rs1042714 or rs1042713 and obesity.
|
19186333 |
2008 |