Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.050 GeneticVariation BEFREE Results from open field and rotarod tests show A53T mice develop age-dependent changes in locomotor activity and reduced anxiety-like behavior. 23936403 2014
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.050 GeneticVariation BEFREE A53T (SNCA) and wild type (WT) littermate mice were evaluated for motor function (rotarod and stride length) and anxiety (elevated plus maze and open field) every 2 weeks. 23938351 2014
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.050 GeneticVariation BEFREE Mice expressing the A53T mutant form of human alpha-synuclein exhibit hyperactivity and reduced anxiety-like behavior. 20077428 2010
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.050 GeneticVariation BEFREE In addition, A53T α-SYN expressing transgenic mice exhibited increased anxiety-like behaviors under normal conditions and abnormal regulation of DBH expression in response to immobilization stress with abnormal adaptive responses. 24252179 2014
Anxiety Disorders
CUI: C0003469
Disease: Anxiety Disorders
0.050 GeneticVariation BEFREE Transgenic A53T is expressed in the monkey brain and causes age-dependent non-motor symptoms, including cognitive defects and anxiety phenotype, without detectable sleeping disorders. 25552648 2016