|
Obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
G1359A Variant of the Cannabinoid Receptor Gene (rs1049353) and Obesity-Related Traits and Related Endophenotypes: A Meta-Analysis.
|
30016776 |
2018 |
|
Obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
The present study aimed to investigate the allelic distribution of polymorphism (G1359A) of the CB1 receptor gene in a geographical area of Spain (Community of Castilla y Leon) and to evaluate the influence of this polymorphism on obesity anthropometric parameters and cardiovascular risk factors in the fasted state in obese patients.
|
25682784 |
2016 |
|
Obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
No significant difference was found between genotypes and alleles of DRD2 Taq1A and DRD2 Taq1B polymorphism in patients and controls, while the CNR1 receptor 1359G/A polymorphism and the presence of the A allele may be one risk factor for susceptibility to obesity.
|
23057570 |
2012 |
|
Obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
Previous studies demonstrated that G1359A polymorphism of cannabinoid receptor-1 (CNR1) was associated with cardiovascular risk factors including obesity, insulin resistance, dyslipidemia, and inflammation, which are also risk factors for developing type 2 diabetes mellitus (T2DM).
|
22138970 |
2012 |
|
Obesity
|
|
0.050 |
GeneticVariation
|
BEFREE |
We therefore genotyped this SNP in 235 independent German obesity families (at least two obese sibs and both parents) and in parallel screened the CNR1 coding region for sequence variations in 120 German extremely obese children and adolescents who mainly contributed to the initial trend observed for rs1049353.
|
17292652 |
2007 |
|
Major Depressive Disorder
|
|
0.040 |
GeneticVariation
|
BEFREE |
Haplotype frequency distributions between MD sample and controls showed a significant difference for Block 1 (rs806368-rs1049353-rs806371) (p = 0.008).
|
23407780 |
2013 |
|
Unipolar Depression
|
|
0.040 |
GeneticVariation
|
BEFREE |
Haplotype frequency distributions between MD sample and controls showed a significant difference for Block 1 (rs806368-rs1049353-rs806371) (p = 0.008).
|
23407780 |
2013 |
|
Unipolar Depression
|
|
0.040 |
GeneticVariation
|
BEFREE |
The rs1049353 polymorphism also buffered the effects of childhood physical abuse on major depressive disorder; however, this influence was largely attributable to anhedonic depression.
|
22393204 |
2012 |
|
Major Depressive Disorder
|
|
0.040 |
GeneticVariation
|
BEFREE |
The rs1049353 polymorphism also buffered the effects of childhood physical abuse on major depressive disorder; however, this influence was largely attributable to anhedonic depression.
|
22393204 |
2012 |
|
Unipolar Depression
|
|
0.040 |
GeneticVariation
|
BEFREE |
We assessed the CB1 receptor gene (CNR1) single nucleotide polymorphism (SNP) rs1049353 (1359 G/A) and the fatty acid amide hydrolase (FAAH) gene rs324420 SNP (cDNA 385C to A) for their associations with MD and/or BD in 83 Caucasian patients with recurrent MD, 134 Caucasian individuals with BD, and 117 Caucasian healthy subjects.
|
20080186 |
2010 |
|
Major Depressive Disorder
|
|
0.040 |
GeneticVariation
|
BEFREE |
We assessed the CB1 receptor gene (CNR1) single nucleotide polymorphism (SNP) rs1049353 (1359 G/A) and the fatty acid amide hydrolase (FAAH) gene rs324420 SNP (cDNA 385C to A) for their associations with MD and/or BD in 83 Caucasian patients with recurrent MD, 134 Caucasian individuals with BD, and 117 Caucasian healthy subjects.
|
20080186 |
2010 |
|
Major Depressive Disorder
|
|
0.040 |
GeneticVariation
|
BEFREE |
Therefore, the impact of cannabinoid receptor 1 gene (CNR1) variants rs1049353 and rs12720071 on antidepressant treatment response was evaluated in 256 Caucasian patients with Major Depression.
|
18579347 |
2008 |
|
Unipolar Depression
|
|
0.040 |
GeneticVariation
|
BEFREE |
Therefore, the impact of cannabinoid receptor 1 gene (CNR1) variants rs1049353 and rs12720071 on antidepressant treatment response was evaluated in 256 Caucasian patients with Major Depression.
|
18579347 |
2008 |
|
Schizophrenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Seven out of the 32 tSNPs within PPARA (rs4253765, rs4263776, rs6007662, rs1800206, rs4253763, rs6008197 and rs4253655) and 3 out of 12 tSNPs within CNR1 (rs1049353, rs7766029 and rs806366) were nominally associated with SZ (uncorrected p<0.05).
|
22920733 |
2013 |
|
Schizophrenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
The possible role of a tag SNP (the 1359G/A polymorphism) of the gene encoding the cannabinoid receptor type 1 (CNR1) in schizophrenia and/or therapeutic response to atypical antipsychotics was assessed in a cohort of 133 French schizophrenic patients compared to 141 normal control subjects.
|
17669634 |
2008 |
|
Schizophrenia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Although the polymorphism 1359G/A was not associated with schizophrenia, the triplet repeat polymorphism of the CNR1 gene was significantly associated with schizophrenia, especially the hebephrenic subtype (P = 0.0028).
|
12082570 |
2002 |
|
Cannabis Dependence
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this study, we discuss the interaction between the 1359 G/A polymorphism of the CNR1 gene and the DRD2 gene polymorphisms and the net effect of any possible epistasis on the cannabis addiction phenotype in a Turkish population.
|
26833047 |
2016 |
|
Impulsive Behavior
|
|
0.020 |
GeneticVariation
|
BEFREE |
The present study aimed to test the hypothesis of an interaction of the two most studied CNR1 polymorphisms rs806379 and rs1049353 with early psychosocial adversity in terms of affecting impulsivity in 15-year-olds from an epidemiological cohort sample followed since birth.
|
24980155 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
Role of genetic variation in the cannabinoid receptor gene (CNR1) (G1359A polymorphism) on weight loss and cardiovascular risk factors after liraglutide treatment in obese patients with diabetes mellitus type 2.
|
24322329 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
G1359A polymorphism of CNR1 may be not associated with T2DM but may contribute to the genetic risk for the presence of CAD in patients with T2DM of Chinese Han population.
|
22138970 |
2012 |
|
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation
|
BEFREE |
The novel finding of this study is the association of the G1359A and A1359A cannabinoid type-1 genotypes with a lower prevalence of metabolic syndrome than the G1359G genotype.
|
21472841 |
2011 |
|
Metabolic Syndrome X
|
|
0.020 |
GeneticVariation
|
BEFREE |
Results suggest that the G1359A polymorphism of the CNR1 gene may contribute to MetS susceptibility in the Chinese Han population.
|
20851297 |
2010 |
|
Cannabis Dependence
|
|
0.020 |
GeneticVariation
|
BEFREE |
Case-control analysis identified a nominal association between SNP rs1049353 and having one or more cannabis dependence symptoms (p=.029), but the association did not hold up in a combined sample.
|
19443135 |
2009 |
|
Impulsive Behavior
|
|
0.020 |
GeneticVariation
|
BEFREE |
Impulsivity was significantly associated with the 6-repeat allele of the triplet repeat polymorphism (AATn/A6; p < .0001), as well as four SNPs in or near the CNR1 receptor gene: rs1535255 (p = .001), rs2023239 (p = .004), rs1049353 (p < .001) and rs806368 (p < .0006).
|
18179391 |
2007 |
|
Dyslipidemias
|
|
0.010 |
GeneticVariation
|
BEFREE |
G1359A Polymorphism of the Cannabinoid Receptor 1 Is Not Associated with Overweight and Dyslipidemia in Young Northeastern Mexicans.
|
31723535 |
2019 |