Disease | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
Acute lymphoblastic leukemia with lymphomatous features
|
0.700 | GeneticVariation | CLINVAR | Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. | 21680795 | 2011 | |||||
Leukemia, Myelocytic, Acute
|
0.700 | GeneticVariation | CLINVAR | Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. | 21680795 | 2011 | |||||
Leukemia, Myelocytic, Acute
|
0.700 | GeneticVariation | CLINVAR | Sequencing a mouse acute promyelocytic leukemia genome reveals genetic events relevant for disease progression. | 21436584 | 2011 | |||||
Leukemia, Acute, X-Linked
|
0.700 | GeneticVariation | CLINVAR | Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers. | 19139102 | 2009 | |||||
Acute lymphoblastic leukemia with lymphomatous features
|
0.700 | GeneticVariation | CLINVAR | Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia. | 19838194 | 2009 | |||||
Acute lymphoblastic leukemia with lymphomatous features
|
0.700 | GeneticVariation | CLINVAR | JAK mutations in high-risk childhood acute lymphoblastic leukemia. | 19470474 | 2009 | |||||
Acute lymphoblastic leukemia with lymphomatous features
|
0.700 | GeneticVariation | CLINVAR | Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers. | 19139102 | 2009 | |||||
Polycythemia Vera
|
0.700 | GeneticVariation | CLINVAR | JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor. | 16239216 | 2005 | |||||
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.010 | GeneticVariation | BEFREE | This mutation was identical to the JAK1 V658F mutation previously found in human APL and acute lymphoblastic leukemia samples. | 21436584 | 2011 | |||||
leukemia
|
0.010 | GeneticVariation | BEFREE | Further analysis showed that JAK1 V658F cooperated in vivo with PML-RARA, causing a rapidly fatal leukemia in mice. | 21436584 | 2011 | |||||
Acute lymphocytic leukemia
|
0.010 | GeneticVariation | BEFREE | This mutation was identical to the JAK1 V658F mutation previously found in human APL and acute lymphoblastic leukemia samples. | 21436584 | 2011 | |||||
Acute Promyelocytic Leukemia
|
0.010 | GeneticVariation | BEFREE | Sequencing of a mouse APL genome revealed 3 somatic, nonsynonymous mutations relevant to APL pathogenesis, of which 1 (Jak1 V657F) was found to be recurrent in other affected mice. | 21436584 | 2011 | |||||
Childhood Leukemia
|
0.010 | GeneticVariation | BEFREE | Further analysis showed that JAK1 V658F cooperated in vivo with PML-RARA, causing a rapidly fatal leukemia in mice. | 21436584 | 2011 |