|
Glaucoma, Open-Angle
|
|
0.810 |
GeneticVariation
|
GWASDB |
Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma.
|
22570617 |
2012 |
|
Glaucoma, Open-Angle
|
|
0.810 |
GeneticVariation
|
BEFREE |
The CDKN2B variant rs1063192 also was found to be associated more strongly with advanced OAG.
|
22840486 |
2012 |
|
Glaucoma, Open-Angle
|
|
0.810 |
GeneticVariation
|
GWASDB |
A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma.
|
22419738 |
2012 |
|
Glaucoma, Open-Angle
|
|
0.810 |
GeneticVariation
|
GWASCAT |
A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma.
|
22419738 |
2012 |
|
Glioma
|
|
0.710 |
GeneticVariation
|
BEFREE |
We hypothesized that CCDKN2A/B rs1063192 and rs4977756 and also the long noncoding RNA (lncRNA) CDKN2BAS rs2157719 glioma susceptibility polymorphisms identified by genome-wide association studies may contribute to medulloblastoma predisposition.
|
29314442 |
2018 |
|
Glaucoma
|
|
0.710 |
GeneticVariation
|
BEFREE |
Stratification analysis by type of glaucoma revealed that rs1063192</span> polymorphism conferred a protective factor of primary open-angle glaucoma (POAG) and non-POAG.
|
28416752 |
2017 |
|
Glioma
|
|
0.710 |
GeneticVariation
|
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
Glaucoma
|
|
0.710 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1.
|
21532571 |
2011 |
|
Glioma
|
|
0.710 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies five susceptibility loci for glioma.
|
19578367 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |
|
Nasopharyngeal Neoplasms
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A GWAS Meta-analysis and Replication Study Identifies a Novel Locus within CLPTM1L/TERT Associated with Nasopharyngeal Carcinoma in Individuals of Chinese Ancestry.
|
26545403 |
2016 |
|
Calcification of coronary artery
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.
|
22144573 |
2011 |
|
Glaucoma, Primary Open Angle
|
|
0.050 |
GeneticVariation
|
BEFREE |
Stratification analysis by type of glaucoma revealed that rs1063192 polymorphism conferred a protective factor of primary open-angle glaucoma (POAG) and non-POAG.
|
28416752 |
2017 |
|
Glaucoma, Primary Open Angle
|
|
0.050 |
GeneticVariation
|
BEFREE |
Polymorphism rs1063192 in CDKN2B is not a risk factor for POAG in Saudi cohort.
|
27541204 |
2016 |
|
Glaucoma, Primary Open Angle
|
|
0.050 |
GeneticVariation
|
BEFREE |
In addition to confirmation of the association of the chromosome 9p21 locus [rs1063192, P= 5.2 × 10(-11), odds ratio (OR) = 0.75], and 14q23 (rs10483727, P = 9.49 × 10(-8), OR = 0.79) with POAG in Caucasians reported recently, we identified a suggestive-associated locus on 2q21 (rs7588567, P = 3.89 × 10(-7), OR = 0.85).
|
22419738 |
2012 |
|
Glaucoma, Primary Open Angle
|
|
0.050 |
GeneticVariation
|
BEFREE |
However, a significant interactive effect on POAG risk was identified between rs1063192</span> and rs7916697 (P-interaction = 2.80 × 10(-5)).
|
22761751 |
2012 |
|
Glaucoma, Primary Open Angle
|
|
0.050 |
GeneticVariation
|
BEFREE |
SNPs associated with VCDR rs1063192 (CDKN2B) and rs10483727 (SIX1/SIX6) were also associated with POAG (P = 0.0006 and P = 0.0043 for rs1063192 and rs10483727, respectively). rs1063192, associated with smaller VCDR, had a protective effect (odds ratio [OR] = 0.73; 95% confidence interval [CI], 0.58-0.90), whereas rs10483727, associated with larger VCDR, increased POAG risk (OR = 1.33; 95% CI, 1.08-1.65).
|
21398277 |
2011 |
|
Low Tension Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
In addition, methylation at CpG sites in CDKN2B was also associated with genotype at rs1063192, which is known to confer risk for NTG.
|
29265947 |
2018 |
|
Low Tension Glaucoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs1063192 (CDKN2B) and rs1900004 (ATOH7) seem to be non-IOP-related genetic risk factors for NTG, and the rs1547014 (CHEK2) is a genetic risk factor for HTG.
|
22584021 |
2012 |
|
Adult Medulloblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We hypothesized that CCDKN2A/B rs1063192 and rs4977756 and also the long noncoding RNA (lncRNA) CDKN2BAS rs2157719 glioma susceptibility polymorphisms identified by genome-wide association studies may contribute to medulloblastoma predisposition.
|
29314442 |
2018 |
|
Medulloblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We hypothesized that CCDKN2A/B rs1063192 and rs4977756 and also the long noncoding RNA (lncRNA) CDKN2BAS rs2157719 glioma susceptibility polymorphisms identified by genome-wide association studies may contribute to medulloblastoma predisposition.
|
29314442 |
2018 |
|
Childhood Medulloblastoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We hypothesized that CCDKN2A/B rs1063192 and rs4977756 and also the long noncoding RNA (lncRNA) CDKN2BAS rs2157719 glioma susceptibility polymorphisms identified by genome-wide association studies may contribute to medulloblastoma predisposition.
|
29314442 |
2018 |
|
Nasopharyngeal carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results also provide support for associations reported from published NPC GWAS-rs6774494 (P = 1.5 × 10(-12); located in the MECOM gene region), rs9510787 (P = 5.0 × 10(-10); located in the TNFRSF19 gene region), and rs1412829/rs4977756/rs1063192 (P = 2.8 × 10(-8), P = 7.0 × 10(-7), and P = 8.4 × 10(-7), respectively; located in the CDKN2A/B gene region).
|
26545403 |
2016 |
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CC genotype of CDKN2B rs1063192 in the hsa-miR-323b-5p binding site increased the risk of GDM in pregnant Chinese Han women.
|
25990668 |
2015 |
|
Piebaldism
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results indicated that four SNPs, CDKN2BAS rs4977756 (p = 0.036), rs1412829 (p = 0.037), rs2157719 (p = 0.018) and rs1063192 (p = 0.021), were associated with an increased susceptibility to PBTs, whereas the TERT rs2736100 was associated with a decreased risk (p = 0.018).
|
26014354 |
2015 |