|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
CDKN2B gene expression is affected by 9p21.3 rs10757278 in CAD patients, six months after the MI.
|
31386834 |
2019 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings indicated that rs1333040, rs1333049, rs2383206, rs2383207, rs10757274 and rs10757278 polymorphisms might serve as genetic biomarkers of CAD in certain ethnicities.
|
30814313 |
2019 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Moreover, rs2383206, rs10757274, and rs10757278 polymorphisms may also serve as genetic biomarkers of CAD in Caucasians and West Asians.
|
30387168 |
2019 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
For rs10757274 and rs10757278, the GG genotype indicated a significant 3-fold and 4-fold increased risk of CAD (p<0.0001,respectively).
|
31472045 |
2019 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study showed that rs10757278/rs2383206-G allele increases the risk for CAD in Egyptians.
|
28559532 |
2017 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
One of the lead single nucleotide polymorphisms, rs10757278, was mostly investigated in association with coronary artery disease but rarely with carotid atherosclerosis.
|
26941057 |
2016 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Human aortic smooth muscle cells (HuAoSMCs) were transfected with siRNA targeting ANRIL exon 19 (siRNA-1) or exon 2 (siRNA-2) and consequent effect determined. rs2383206 showed the highest association with CAD (odds ratio [OR] 2.02, 95% confidence interval [CI] 1.56 -2.62) and an adjusted OR of 2.55, 1.33-2.88 along with rs10757278.
|
24452806 |
2014 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Common variants in the 9p21.3 locus have been reported to be associated with multiple cardiovascular phenotypes, including coronary artery disease and intracranial aneurysms (rs10757278 and rs1333040).
|
24777168 |
2014 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Analysis of the rs10757278, rs11881940 and rs3803 loci showed that haplotypes ATC (OR = 4.26; 95%CI = 2.85-6.40, P < 0.01), GAC (OR = 1.50; 95%CI = 1.25-1.81, P < 0.01) and GAT (OR = 1.53; 95%CI = 1.12-2.09, P < 0.01) were CAD risk factors, whereas GTC was protective (OR = 0.48; 95%CI = 0.32-0.72, P < 0.01).
|
24782050 |
2014 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently independent studies reported an association between coronary heart disease and single-nucleotide polymorphisms (SNPs) located at chromosome 9p21 (rs10757278 and proxy SNPs).
|
24625579 |
2014 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A case-control study to investigate the association of the 9p21 single nucleotide polymorphisms (SNPs) rs10757274 and rs10757278 (known to be associated with coronary artery disease [CAD] risk) with peripheral arterial disease (PAD), in a Han Chinese population.
|
23569135 |
2013 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Allelic variants of the rs10757278 polymorphism functionally affect the activity of the 9p21.3 locus; therefore, we conducted a study to determine whether the rs10757278 is associated with premature CAD in Polish patients.
|
22946666 |
2012 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Common variation at chromosome 9p21 (marked by rs10757278 or rs1333049) is associated with coronary artery disease (CAD) and peripheral vascular disease.
|
21852414 |
2011 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The CAD risk alleles of SNPs rs10811656 and rs10757278 are located in one of these enhancers and disrupt a binding site for STAT1.
|
21307941 |
2011 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs10757278 G variant at the 9p21 locus is significantly associated with the risk of CAD in our population of Western India, similar to the observed trend in other populations; however, the association is much stronger in the present cohort and, considering the high propensity of Indians to develop CAD, it is an important marker even in terms of risk classification.
|
21925557 |
2011 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no association between rs10757278 allele frequency and stroke status based on the presence or absence of angiographically demonstrated CAD in nonstroke controls (ANCOVA, p = 0.99).
|
21088391 |
2011 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The haplotypes constructed using four risk SNPs revealed that the haplotypes with combinations of rs10757278 showed CAD risks, whereas the minor alleles of rs2383207, rs1537375, and rs1537374 in combinations reduce the CAD risks substantially.
|
20858033 |
2011 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We replicated the association between the rs10757278 SNP and myocardial infarction and binary (presence/absence) angiographic classifications of CAD.
|
20729229 |
2010 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significantly reduced expression of all INK4/ARF transcripts (p15(INK4b), p16(INK4a), ARF and ANRIL) was found in PBTL of individuals harboring a common SNP (rs10757278) associated with increased risk of coronary artery disease, stroke and aortic aneurysm.
|
19343170 |
2009 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The risk variant on chromosome 9, tagged by rs10757278, is associated with coronary heart disease in the Belgian population, but not with isolated CVD.
|
19319159 |
2009 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Conclusions The rs10757278 and rs2383207 variants are determinants for early-onset coronary artery disease.
|
18459066 |
2009 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the first study, rs2383206, rs1004638, and rs10757278 in block 3 were significantly associated with CAD but not with ischemic stroke independent of traditional cardiovascular risk factors in additive model (P = 0.002 to 0.0001, q = 0.026 to 0.004).
|
20031605 |
2009 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) = 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D.
|
18176561 |
2008 |
|
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genome-wide single nucleotide polymorphism (SNP) association studies recently identified four SNPs (rs10757274, rs2383206, rs2383207, and rs10757278) on chromosome 9p21 that were associated with coronary artery disease (CAD) and myocardial infarction (MI) in Caucasian populations from northern Europe and North America.
|
18066490 |
2008 |