|
C-reactive protein measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers.
|
23505291 |
2013 |
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation
|
BEFREE |
Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108-0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143-0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270-0.942, P = 0.032).
|
29556849 |
2018 |
|
Lupus Erythematosus, Systemic
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs1130864 CRP polymorphism was associated with SLE susceptibility and CRP levels, but not with disease activity, suggesting that this polymorphism may play a role in the pathophysiology of SLE through increasing the CRP that, probably, plays an inflammatory role in SLE pathophysiology.
|
28567557 |
2017 |
|
Mental Depression
|
|
0.020 |
GeneticVariation
|
BEFREE |
The minor alleles of rs1130864 and rs1417938 were associated with a decreased risk of depression in women at Bonferroni-corrected significance levels (P=0.002).
|
25603415 |
2015 |
|
Depressive disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
The minor alleles of rs1130864 and rs1417938 were associated with a decreased risk of depression in women at Bonferroni-corrected significance levels (P=0.002).
|
25603415 |
2015 |
|
Depressed mood
|
|
0.020 |
GeneticVariation
|
BEFREE |
The minor alleles of rs1130864 and rs1417938 were associated with a decreased risk of depression in women at Bonferroni-corrected significance levels (P=0.002).
|
25603415 |
2015 |
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The present case control study investigated the contribution of three relevant CRP single nucleotide polymorphisms: -717A>G located in the promoter region (rs2794521), +1059G>C on exon2 (rs1800947) and +1444C>T in the 3' UTR (rs1130864) in 180 angiographically verified CHD cases and 175 control subjects.
|
24965144 |
2014 |
|
Mental Depression
|
|
0.020 |
GeneticVariation
|
BEFREE |
Men with the CT and TT genotypes of rs1130864 had 1.36 (95% CI = 1.13-1.63) and 2.31 (95% CI = 1.65-3.24) greater odds of CRP > or = 3 mg/l than CC carriers, but there was no association between this polymorphism and the presence of prevalent depression.
|
19433520 |
2009 |
|
Depressive disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
Men with the CT and TT genotypes of rs1130864 had 1.36 (95% CI = 1.13-1.63) and 2.31 (95% CI = 1.65-3.24) greater odds of CRP > or = 3 mg/l than CC carriers, but there was no association between this polymorphism and the presence of prevalent depression.
|
19433520 |
2009 |
|
Depressed mood
|
|
0.020 |
GeneticVariation
|
BEFREE |
Men with the CT and TT genotypes of rs1130864 had 1.36 (95% CI = 1.13-1.63) and 2.31 (95% CI = 1.65-3.24) greater odds of CRP > or = 3 mg/l than CC carriers, but there was no association between this polymorphism and the presence of prevalent depression.
|
19433520 |
2009 |
|
Coronary heart disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
We found no association of a genetic variant, which is known to be related to CRP levels, (rs1130864) and having CHD.
|
18714384 |
2008 |
|
Atherosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We genotyped 3 tag single nucleotide polymorphisms (SNPs) [+1444T>C (rs1130864); +2303G>A (rs1205) and +4899T>G (rs 3093077)] in the CRP gene and assessed CRP and carotid intima-media thickness (CIMT), a structural marker of atherosclerosis, in 4941 men and women aged 50-74 (mean 61) years (the Whitehall II Study).
|
18714381 |
2008 |
|
Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We genotyped 3 tag single nucleotide polymorphisms (SNPs) [+1444T>C (rs1130864); +2303G>A (rs1205) and +4899T>G (rs 3093077)] in the CRP gene and assessed CRP and carotid intima-media thickness (CIMT), a structural marker of atherosclerosis, in 4941 men and women aged 50-74 (mean 61) years (the Whitehall II Study).
|
18714381 |
2008 |
|
Atherosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We concluded that rs3091244, rs1130864 and the T-T-G haplotype are genetic markers for elevated basal CRP levels. rs1800947 and the C-C-C haplotype appear to be susceptibility markers for atherosclerosis, but this requires confirmation.
|
16832152 |
2006 |
|
Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
We concluded that rs3091244, rs1130864 and the T-T-G haplotype are genetic markers for elevated basal CRP levels. rs1800947 and the C-C-C haplotype appear to be susceptibility markers for atherosclerosis, but this requires confirmation.
|
16832152 |
2006 |
|
Non-alcoholic Fatty Liver Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The study was conducted to investigate the association of CRP rs1130864 (1444C/T), IL-6 rs1800795 (-174G/C) and LEPR rs1137101 (Q223R) genes with OSA and NAFLD in Asian Indians residing in North India.
|
30001365 |
2018 |
|
Lupus Vulgaris
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108-0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143-0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270-0.942, P = 0.032).
|
29556849 |
2018 |
|
Lupus Erythematosus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108-0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143-0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270-0.942, P = 0.032).
|
29556849 |
2018 |
|
Sleep Apnea, Obstructive
|
|
0.010 |
GeneticVariation
|
BEFREE |
The study was conducted to investigate the association of CRP rs1130864 (1444C/T), IL-6 rs1800795 (-174G/C) and LEPR rs1137101 (Q223R) genes with OSA and NAFLD in Asian Indians residing in North India.
|
30001365 |
2018 |
|
Lupus Erythematosus, Discoid
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four of the polymorphisms showed differences between patients and controls. rs3093061 polymorphism was associated with a lower risk of developing lupus principally in the codominant 2 (OR = 0.219, 95% CI 0.108-0.785, P = 0.015) model. rs1130864 was associated with decreased risk mainly under codominant 1 (OR = 0.288, 95% CI 0.143-0.581, P = 0.001) model. rs1205 was associated under the over-dominant model (OR = 0.504, 95% CI 0.270-0.942, P = 0.032).
|
29556849 |
2018 |
|
Thyroid Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, the CRP rs1130864 A allele carrier state was significantly more frequent: (i) in BD patients with thyroid disorders than in those without (pc = 0.046), especially among females (pc = 0.01) and independently of lithium treatment, (ii) in BD patients with rapid cycling than in those without (pc = 0.004).
|
29352395 |
2018 |
|
Bacterial Endocarditis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the G/A genotype of the rs1143634 polymorphism within the <i>IL1B</i> gene, the G/T genotype of the rs3212227 polymorphism within the <i>IL12B</i> gene, the A/G genotype of the rs1130864 polymorphism within the <i>CRP</i> gene, and the G allele of the rs1801197 polymorphism within the <i>CALCR</i> gene were associated with a decreased risk of IE whereas the T/T genotype of the rs1205 polymorphism within the <i>CRP</i> gene was associated with a higher risk of IE.
|
28659664 |
2017 |
|
Infective endocarditis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that the G/A genotype of the rs1143634 polymorphism within the <i>IL1B</i> gene, the G/T genotype of the rs3212227 polymorphism within the <i>IL12B</i> gene, the A/G genotype of the rs1130864 polymorphism within the <i>CRP</i> gene, and the G allele of the rs1801197 polymorphism within the <i>CALCR</i> gene were associated with a decreased risk of IE whereas the T/T genotype of the rs1205 polymorphism within the <i>CRP</i> gene was associated with a higher risk of IE.
|
28659664 |
2017 |
|
Age related macular degeneration
|
|
0.010 |
GeneticVariation
|
BEFREE |
In the pooled results of all 3 studies, neither rs1205 (odds ratio [OR], 0.99; 95% CI, 0.86-1.14) nor rs1130864 (OR, 0.96; 95% CI, 0.83-1.11) was associated with late AMD.
|
28750115 |
2017 |
|
Geographic Atrophy
|
|
0.010 |
GeneticVariation
|
BEFREE |
For geographic atrophy, rs1205 had an OR of 0.91 (95% CI, 0.74-1.13) and rs1130864 had an OR of 0.94 (95% CI, 0.76-1.16).
|
28750115 |
2017 |