|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.780 |
GeneticVariation
|
BEFREE |
The Common <i>HNF1A</i> Variant I27L Is a Modifier of Age at Diabetes Diagnosis in Individuals With HNF1A-MODY.
|
29895593 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.780 |
GeneticVariation
|
GWASCAT |
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
|
29632382 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.780 |
GeneticVariation
|
BEFREE |
Mutation p.T130I was associated with both early-onset and late-onset diabetes and caused downregulated HNF4A expression, whereas HNF1A polymorphisms p.I27L and p.S487N were associated with the age of diagnosis of diabetes.
|
26981542 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.780 |
GeneticVariation
|
BEFREE |
These findings suggest that the HNF1A p.I27L (rs1169288) variant may be a significant risk factor of T2DM in normal-weight subjects and that earlier inconsistent results may have been due, in part, to subjects' weight status.
|
24933231 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.780 |
GeneticVariation
|
BEFREE |
In this study, we asked whether the co-occurrence of risk alleles in or near five genes modulating insulin secretion (TCF7L2 rs7903146, IGF2BP2 rs4402960, CDKAL1 rs7754840, HHEX rs1111875, and HNF1A rs1169288) is associated with a higher risk of IGT/T2D in obese children and adolescents.
|
24062323 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.780 |
GeneticVariation
|
BEFREE |
In contrast, 33.3% of patients with type 2 diabetes mellitus and I27L polymorphism in the HNF1alpha gene had no family history of diabetes (p < 0.05).
|
20172480 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.780 |
GeneticVariation
|
BEFREE |
Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94).
|
18498634 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.780 |
GeneticVariation
|
BEFREE |
The polymorphism rs1169288 in HNF-1alpha strongly predicted future type 2 diabetes (hazard ratio [HR] 1.2, P = 0.0002).
|
18332101 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.780 |
GeneticVariation
|
BEFREE |
In a new case-control (n = 1,511 and n = 2,225 respectively) data set, the I27L polymorphism was associated with increased risk of type 2 diabetes, odds ratio (OR) = 1.5 (p = 0.002; multiple logistic regression), particularly in elderly (age > 60 years) and overweight (BMI > 25 kg/m(2)) patients (OR = 2.3, p = 0.002).
|
17033837 |
2006 |