Disease: Lung Neoplasms ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Lung Neoplasms
CUI: C0024121
Disease: Lung Neoplasms
0.060 GeneticVariation BEFREE Identifying nonsmall-cell lung tumours bearing the T790M EGFR TKI resistance mutation using PET imaging. 31132309 2019
Lung Neoplasms
CUI: C0024121
Disease: Lung Neoplasms
0.060 GeneticVariation BEFREE In tyrosine kinase inhibitor-resistant lung tumors, rociletinib and AZD9291 are highly active when T790M is present and modestly active when T790M is absent. 26058074 2015
Lung Neoplasms
CUI: C0024121
Disease: Lung Neoplasms
0.060 GeneticVariation BEFREE Rapamycin prevents the development and progression of mutant epidermal growth factor receptor lung tumors with the acquired resistance mutation T790M. 24931608 2014
Lung Neoplasms
CUI: C0024121
Disease: Lung Neoplasms
0.060 GeneticVariation BEFREE Pharmacologic inhibition of β-catenin suppressed EGFR-L858R-T790M mutated lung tumor growth, and genetic deletion of the β-catenin gene dramatically reduced lung tumor formation in EGFR-L858R-T790M transgenic mice. 25164010 2014
Lung Neoplasms
CUI: C0024121
Disease: Lung Neoplasms
0.060 GeneticVariation BEFREE Nevertheless, several lines of evidence indicate that the T790M mutation confers growth advantage to cancer cells, and it was shown that mice expressing tetracycline-inducible EGFR transgenes harboring the T790M mutation develop lung tumors. 19096299 2009
Lung Neoplasms
CUI: C0024121
Disease: Lung Neoplasms
0.060 GeneticVariation BEFREE MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. 18093943 2007