Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic effect of MTHFR C677T polymorphism on the structural covariance network and white-matter integrity in Alzheimer's disease.
|
28342207 |
2017 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
<i>MTHFR</i> C677T TT and CT genotypes had significant associations with AD risk in all ra</span>cial populations (RR = 1.13, <i>p</i> = 0.0047; and RR = 1.12, <i>p</i> < 0.0001 respectively).
|
28085050 |
2017 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Results of present meta-analysis supported that the MTHFR C677T polymorphism was associated with an increased risk of AD.
|
26820674 |
2017 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
These reports were combined with related observational studies, and used to evaluate the effect of MTHFR C677T (rs1801133) on the risk for AD.
|
27031476 |
2016 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This report suggests the value of genotyping patients at the C677T functional variant when using plasma ApoE levels as a preclinical biomarker for Alzheimer's disease.
|
27380243 |
2016 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T polymorphism may be a risk factor for AD in Asians, APOE ϵ4 carriers, and late-onset AD.
|
25486592 |
2015 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR 677C>T polymorphism--especially the presence of one copy of the T allele--appears to confer a potential risk for the development of AD.
|
24223459 |
2013 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic analyses did not indicate a significant association between the MTHFR C677T mutation and A</span>D (C/T: 63.15% versus 39%, p=0.087).
|
23659764 |
2013 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In this case-control study, we examined C677T and A1298C (rs1801133 and rs1801131) polymorphism in the methylenetetrahydrofolate reductase (MTHFR) genes and their correlation with plasma levels of homocysteine (Hcy) in AD and VaD cases and evaluated the gene-gene interaction (epistasis) with IL-6-174 G/C (rs1800795).
|
22015309 |
2012 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T polymorphism is associated with AD in Asian populations, but not in Caucasians.
|
21663380 |
2011 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis supports that MTHFR C677T polymorphism is capable of causing AD susceptibility in East Asians, not in Caucasians.
|
20600372 |
2010 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The presence of the MTHFR 677 C/T and 677 T/T genotypes conferred a marginally significant increase in the risk for AD (OR = 1.666, 95% CI = 1.022-2.715, and OR = 1.892, 95% CI = 1.124-3.187) and the presence of the IL-8 -251 polymorphism was not associated with AD.
|
19246914 |
2009 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of RFC1 A80G and MTHFR C677T polymorphisms with Alzheimer's disease.
|
18258338 |
2009 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
A trend of association between TT genotype of MTHFR c.677C>T and AD was found [adjusted OR (95% CI): 1.73 (0.80-3.74)].
|
17932993 |
2008 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In AD there were significant differences of the levels of only Cys (GG, MTHFR, G1793A) and Met/Hcy (AA, MTHFD1, G1958A) whereas in PD there were more significant differences of the levels of thiols: Hcy [MTHFR: CT (C677T) and GG (G1793A); MTR, AG (A2756G)], Met [MTR, AA (A2756G)], Cys [MTR, AG (A2756G)], and Met/Hcy [MTHFR: CC, CT (C677T) and AA (A1298C), and GG (G1793A); MTHFD1 AA(G1958A); MTR AA(A2756G)].
|
17691219 |
2007 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data confirms the association between increased plasma Hcy concentration and AD and suggests that neither C677T nor A1298C MTHFR polymorphisms contributed to genetic susceptibility for AD in elderly individuals in the Northeast of Brazil.
|
17221000 |
2006 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the MTHFR gene C677T polymorphism has a significant impact on reducing enzyme activity and increasing t-Hcy concentrations, the association between the C677T polymorphism and AD remains inconclusive.
|
16055944 |
2005 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In spite of the evidence that a C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene elevates plasma Hcy levels, the impact of the C677T polymorphism on the development of AD is controversial.
|
15123333 |
2004 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In spite of a significant impact of a MTHFR C677T polymorphism on the blood homocysteine levels, the association between the C677T polymorphism and AD remains controversial.
|
14739536 |
2004 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This may be associated with the T/T genotype in the MTHFR gene; however, the distribution of the MTHRF C677T polymorphism in the Polish population does not differ in AD and controls.
|
12784029 |
2003 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We failed to show independent associations between AD and the common MTHFR polymorphisms (C677T and A1298C).
|
12480755 |
2002 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Plasma tHcy levels, homozygosity for the C677T mutation of the MTHFR gene, and folate and vitamin B(12) plasma levels were evaluated in 74 patients with AD (45 men, 29 women, mean age 68 years) and in 74 healthy matched controls (42 men, 32 women, mean age 68 years).
|
11721146 |
2002 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Some examples include the alanine-to-valine substitution at codon 222 (Ala222-->Val) [DNA: C-to-T substitution at nucleo-tide 677 (677C-->T)] in methylenetetrahydrofolate reductase (NADPH) and the cofactor FAD (in relation to cardiovascular disease, migraines, and rages), the Pro187-->Ser (DNA: 609C-->T) mutation in NAD(P):quinone oxidoreductase 1 [NAD(P)H dehy-drogenase (quinone)] and FAD (in relation to cancer), the Ala44-->Gly (DNA: 131C-->G) mutation in glucose-6-phosphate 1-dehydrogenase and NADP (in relation to favism and hemolytic anemia), and the Glu487-->Lys mutation (present in one-half of Asians) in aldehyde dehydrogenase (NAD + ) and NAD (in relation to alcohol intolerance, Alzheimer disease, and cancer).
|
11916749 |
2002 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The distribution of the C677T polymorphism did not differ in AD and controls.
|
11711225 |
2001 |
Alzheimer's Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T is not associated with an increased risk of vascular dementia or Alzheimer's disease.
|
10855603 |
2000 |