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Malignant Neoplasms
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0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is a genetic factor that has been associated with many pathologies, including cancer.
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31170928 |
2019 |
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Malignant Neoplasms
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0.100 |
GeneticVariation
|
BEFREE |
For children with malignancy, genotyping of the MTHFR C677T polymorphism is expected to be a useful tool in reducing toxicity and improving outcome in personalized MTX therapy.
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28696419 |
2018 |
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Malignant Neoplasms
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0.100 |
GeneticVariation
|
BEFREE |
Association between the MTHFR C677T polymorphism and risk of cancer: evidence from 446 case-control studies.
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26081619 |
2015 |
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Malignant Neoplasms
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0.100 |
GeneticVariation
|
BEFREE |
The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and to contribute to tumor promotion in the mammary gland.
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25966173 |
2015 |
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Malignant Neoplasms
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|
0.100 |
GeneticVariation
|
BEFREE |
The methylenetetrahydrofolate reductase (MTHFR) 677 C>T and 1298 A>C polymorphisms are associated with variations in folate levels, a phenomenon linked to the development of various malignancies.
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25510667 |
2015 |
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Malignant Neoplasms
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0.100 |
GeneticVariation
|
BEFREE |
MTHFR variants may cause genomic hypomethylation, which may lead to the development of cancer, and MTHFR gene polymorphisms (especially C677T and A1298C) are known to influence predispositions for cancer development.
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26745044 |
2015 |
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Malignant Neoplasms
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|
0.100 |
GeneticVariation
|
BEFREE |
Two common polymorphisms are reported, C677T and A1298C, that are implicated in a number of human diseases, including cancer.
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25921104 |
2015 |
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Malignant Neoplasms
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0.100 |
GeneticVariation
|
BEFREE |
To identify if methylene tetra-hydrofolatereductase (MTHFR) C677T polymorphisms are associated with oesophageal adenocarcinomas in a Caucasian population and to test whether folic acid and homocysteine levels are linked with cancer risk.
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25232254 |
2014 |
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Malignant Neoplasms
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0.100 |
GeneticVariation
|
BEFREE |
The role of the MTHFR 677C>T polymorphism in methotrexate-induced liver toxicity: a meta-analysis in patients with cancer.
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23648444 |
2014 |
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Malignant Neoplasms
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|
0.100 |
GeneticVariation
|
BEFREE |
Two common genetic variants, C677T and A1298C, of MTHFR are associated with number of human diseases, including cancer, as well as being involved in the modulation of therapy outcome to antifolate drugs.
|
24533714 |
2014 |
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Malignant Neoplasms
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0.100 |
GeneticVariation
|
BEFREE |
Additionally, more high-quality studies and that the covariates responsible for heterogeneity should be controlled to obtain a more conclusive response about the function of MTHFR C677T in cancer.
|
24744129 |
2014 |
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Malignant Neoplasms
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0.100 |
GeneticVariation
|
BEFREE |
The T allele of MTHFR C677T was significantly more frequently found in controls than in patients with cancer.
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25075036 |
2014 |
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Malignant Neoplasms
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0.100 |
GeneticVariation
|
BEFREE |
Methylene tetrahydrofolate reductase C677T leads to a decrease of about 30% in its product activity and is reported to have an effect on cancer susceptibility.
|
23934457 |
2013 |
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Malignant Neoplasms
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0.100 |
GeneticVariation
|
BEFREE |
However, we did not find association between polymorphism in MTHFR C677T and risk of hypermethylation in P16, MGMT, hMLH1 and hMLH2 genes either in cancer or remote normal-appearing tissues.
|
23803092 |
2013 |
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Malignant Neoplasms
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0.100 |
GeneticVariation
|
BEFREE |
A literature review of MTHFR (C677T and A1298C polymorphisms) and cancer risk.
|
23076526 |
2013 |
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Malignant Neoplasms
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|
0.100 |
GeneticVariation
|
BEFREE |
Our objective was to evaluate the MTHFR C677T-A1298C polymorphisms in patients with breast cancer and in individuals with no history of cancer, to compare the levels of genetic damage and apoptosis under folic acid (FA) deficiency between patients and controls, and to assess associations with breast cancer.
|
22901194 |
2012 |
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Malignant Neoplasms
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|
0.100 |
GeneticVariation
|
BEFREE |
Two important polymorphisms of folate cycle enzymes, methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase (TS) enhancer region (TSER) 28-bp tandem repeat, are related to risk of various types of cancer, including brain tumors, although there are few studies on this subject.
|
21848426 |
2012 |
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Malignant Neoplasms
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|
0.100 |
GeneticVariation
|
BEFREE |
This study aims to evaluate the role of MTHFR C677T and A1298C polymorphisms and G80A reduced folate carrier gene (RFC1) in a cohort of adult patients with lymphoproliferative malignancies submitted to high-dose MTX followed by leucovorin rescue.
|
21984221 |
2012 |
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Malignant Neoplasms
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|
0.100 |
GeneticVariation
|
BEFREE |
The two common functional polymorphisms of MTHFR, 677 C→T and 1298 A→C, have been shown to impact various diseases, including cancer.
|
21732284 |
2011 |
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Malignant Neoplasms
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0.100 |
GeneticVariation
|
BEFREE |
However, in meta-analyses odds ratio for MTHFR c.677C>T</span> homozygotes versus noncarriers were 1.07 (95% CI: 1.01-1.12) for any cancer, 1.77 (1.17-2.68) for esophagus cancer, 1.40 (1.19-1.66) for gastric cancer and 0.85 (0.77-0.94) for colorectal cancer.
|
20473868 |
2011 |
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Malignant Neoplasms
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|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate MTHFR C677T polymorphism in patients with head and neck squamous cell carcinoma and in individuals with no history of cancer, and to assess the association of this disease with clinical histopathological parameters.
|
21180947 |
2011 |
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Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The two common functional polymorphisms of MTHFR, C677T and A1298C have been associated with several diseases, including cancer.
|
22194208 |
2011 |
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The two common functional polymorphisms of MTHFR, 677 C-->T and 1298 A-->C have shown to impact several diseases including cancer.
|
20516537 |
2010 |
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Malignant Neoplasms
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|
0.100 |
GeneticVariation
|
BEFREE |
Accumulating evidence has indicated that two common genetic variants, C677T and A1298C, are associated with cancer risk.
|
20002681 |
2010 |
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Malignant Neoplasms
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|
0.100 |
GeneticVariation
|
BEFREE |
A C/T transition at position 677 in the gene encoding methlylenetetrahydrofolate reductase (MTHFR C677T) has been reported to interact with folate intake to modulate colorectal adenoma recurrence or cancer risk.
|
18322814 |
2008 |