|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The distribution of genotype frequency at C677T polymorphism site was significantly different between the CHD group (including ventricular septal defect, atrial septal defect, tetralogy of fallot, double outlet right ventricle, patent ductus arteriosus) (child and mother) and healthy control group (child and mother).
|
30334422 |
2019 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Both <i>MTHFR</i> C677T (rs 1801133) and A1298C (rs 1801131) gene polymorphisms were risks for CHD in children with transgenerational effects from their parents.
|
30081597 |
2018 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the subgroup stratified by region, sample size, genotyping method and source of controls, the increased risks were widely observed in both the C677T and A1298C polymorphisms with CHD risk.
|
29554656 |
2018 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The pooled ORs and 95% CIs in all genetic models indicated that children's MTHFR C677T polymorphism was significantly associated with CHD.
|
28591039 |
2017 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T is a potential risk factor for CHD in our local residents of Shandong province in China.
|
26990189 |
2016 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Taken together, this suggests that serum HCY levels and MTHFR C677T genotypes are correlated with CHD.
|
27051002 |
2016 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase C677T polymorphism is associated with increased risk of coronary artery disease in young South African Indians.
|
26095803 |
2015 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Congenital heart defects (CHD) are the third leading cause of death in children <1 year of age in Mexico where there is a high prevalence of the 677C → T polymorphism of the MTHFR gene.
|
22660520 |
2013 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of MTHFR C677T gene variants and lipid profiles or body mass index in patients with diabetic and nondiabetic coronary heart disease.
|
24218123 |
2013 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Both infant and maternal MTHFR C677T polymorphisms may contribute to the risk of CHDs.
|
23536781 |
2013 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Compound mutants for (MTHFD-G1958A, MTHFR-C677T and MTR-A2756G) and (MTHFD-G1958A, RFC1-G80A and MTR-A2756G) may increase the risk of CHD.
|
23701284 |
2013 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis of the results showed significant associations between the maternal C677T polymorphism and CHD risk (CC vs TT: OR = 0.65, 95%CI = 0.44-0.96).
|
24338416 |
2013 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR C677T polymorphism, which directly influences plasma folate levels, is not associated with CHD risk.
|
23876493 |
2013 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
An association between combined MTHFR A1298C and C677T polymorphisms and CHD was recorded in the children and their mothers.
|
23933414 |
2013 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the relationship of the MTHFR C677T polymorphism with the risk of CHD in children with CHD and their parents by meta-analysis.
|
22175539 |
2012 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Role of homocysteine & MTHFR C677T gene polymorphism as risk factors for coronary artery disease in young Indians.
|
22664498 |
2012 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate reductase C677T gene polymorphism and coronary artery disease in a Chinese Han population: a meta-analysis.
|
22146089 |
2012 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The merits of two techniques, molecular beacon and amplification effect of enzymatic color, are successfully combined, and the technique is simple, sensitive and specific, to detect and compare the methylenetetrahydrofolate reductase (MTHFR) Gene C677T mutation of subjects between coronary heart disease (CHD) and control group.
|
21802936 |
2011 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In a Dutch population-based case-control study of 143 children with CHD and 186 healthy children, we investigated S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), total homocysteine (tHcy), the vitamins folate and B12 and the functional single nucleotide polymorphisms in the folate gene MTHFR 677C>T and 1298A>C.
|
20868449 |
2011 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggests that genotypes for the MTHFR C677T polymorphism might be associated with the risk of CHD among Caucasians.
|
21793799 |
2011 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T polymorphism of 5,10 methylenetetrahydrofolate reductase (MTHFR) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial.
|
20637366 |
2010 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This case-control study aimed to evaluate the effect of maternal C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) as risk factors for the development of DS and congenital heart defects (CHD).
|
19725133 |
2009 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with early onset of coronary artery disease in some populations with certain ethnic backgrounds.
|
18751630 |
2008 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Plasma homocysteine levels & 677C-->T methylenetetrahydrofolate reductase gene polymorphism in patients with coronary artery disease of different severity.
|
18403793 |
2008 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, in persons with the CC variant for the MTHFR 677 C>T genotype, a significantly protective effect against CHD [0.71 (95% CI 0.58-0.87)] was shown, although in the CT [1.25 (95% CI 0.97-1.61)] and TT groups [0.80 (95% CI 0.50-1.28)] there were no such effects (interaction hazard ratio P=0.004).
|
18622257 |
2008 |