|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Via MTHFR C677T polymorphism, the findings in the present study demonstrated that there exists evidence on causal link between Hcy concentration and the risk of hypertension.
|
31769183 |
2019 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Clinical and genetic variables associated with ischaemic stroke were hypertension (P=.03), tobacco use (P=.02), and the polymorphisms Glu298Asp (genotype: P=.001, allele frequency: P=.001) and C677T (genotype: P=.01); the Ala147Thr, Thr325IIe, 4G/5G, and PLA1/A2 mutations were not associated with ischaemic stroke.
|
29526315 |
2018 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygous mutant TT genotype of 677C/T of the MTHFR gene may be an important genetic factor of H-type hypertension.
|
27973469 |
2017 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Individual and Joint Associations of Methylenetetrahydrofolate Reductase C677T Genotype and Plasma Homocysteine With Dyslipidemia in a Chinese Population With Hypertension.
|
26442927 |
2017 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Epidemiological studies, which provide a separate line of evidence to link this gene with blood pressure, show that the 677C→T polymorphism in MTHFR increases the risk of hypertension by 24-87% and CVD by up to 40%, albeit with a large geographical variation in the extent of excess disease risk suggestive of a gene-environment interaction.
|
27720779 |
2017 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our major findings suggest that joint effects of the MTHFR C677T polymorphism and hypertension are consistent in predicting a significantly high risk of stroke.
|
27126505 |
2017 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This work showed that genetic polymorphism related to the MTHFR gene (C677T) is not associated with the risk of hypertension in this sample of Algerian population.
|
27780089 |
2016 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for the common C677T polymorphism in MTHFR, affecting over 10 % of the UK and Irish populations and up to 32 % of other populations worldwide, has been associated with an increased risk of CVD, and more recently with hypertension.
|
27170501 |
2016 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to explore the associations of the MTHFR C677T polymorphism, environmental factors, and their interactions with hypertension predisposition in a Northern Chinese Han population.
|
27322299 |
2016 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We measured plasma total homocysteine tHcy level and C677T genotype in 1058 Chinese patients with hypertension from 4 previous studies.
|
24459043 |
2015 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR 677 C>T and ApoE polymorphisms demonstrated significant associations with susceptibility to hypertension in multiple logistic regression models, multifactor dimensionality reduction and a classification and regression tree.
|
25055800 |
2015 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of the present study was to evaluate the effect of simvastatin treatment on circulating Hcy levels in obese women without hypertension, diabetes or dyslipidaemia; and to determine whether the 677C>T polymorphism located in methylenetetrahydrofolate reductase (NAD(P)H) (MTHFR) gene modulates the effects of this treatment on Hcy and nitrite (as a biomarker of nitric oxide (NO) bioavailability).
|
25115547 |
2014 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The prevalence of hypertension (P < .001), smoking (P < .001), decreased HDL cholesterol levels (P < .001), obesity (P = .001), elevated LDL cholesterol (P = .036), C677T MTHFR polymorphism (P < .001), and genetic sum was significantly higher in the group of stroke patients.
|
24189452 |
2014 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T polymorphism has been studied as a possible risk factor for a variety of common conditions including heart disease, stroke and hypertension.
|
24192663 |
2014 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several epidemiological studies have investigated the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms with hypertension (H) or hypertension in pregnancy (HIP).
|
24505291 |
2014 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found an association between the 677C>T MTHFR polymorphism and tHcy with hypertension that in women is manifested with age.
|
22676332 |
2013 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Strong association of methylenetetrahydrofolate reductase gene C677T polymorphism with hypertension and hypertension-in-pregnancy in Chinese: a meta-analysis.
|
21346782 |
2012 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further, 2 functional MTHFR variants, 1298A>C and 677C>T, which are not in linkage disequilibrium in this population, were significantly associated with hypertension (OR = 1.72, P = 0.024, and OR = 1.60, P = 0.002, respectively).
|
21270364 |
2011 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T polymorphism of 5,10 methylenetetrahydrofolate reductase (MTHFR) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial.
|
20637366 |
2010 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Synergistic effects of the MTHFR C677T polymorphism and hypertension on spatial navigation.
|
19013496 |
2009 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Of six polymorphisms (677C>T-MTHFR, 1298A>C-MTHFR, 80G>A-RFC, 2756A>G-MS, 66A>G- MSR, 19bpDHFR and 1561C>T-GCPII), only 677C>T-MTHFR was a significant risk for hypertension: OR 1.89; 95% CI 1.07-3.32 (chi2 p = 0.038).
|
19776634 |
2009 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T mutation may contribute to hypertension or affect the development of hypertension through hyperhomocysteinemia.
|
18855261 |
2008 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactions between the single nucleotide polymorphisms in the homocysteine pathway (MTHFR 677C>T, MTHFR 1298 A>C, and CBSins) and the efficacy of HMG-CoA reductase inhibitors in preventing cardiovascular disease in high-risk patients of hypertension: the GenHAT study.
|
18622257 |
2008 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Evidence of significant association was detected between C677T polymorphism and hyper</span>tension in both populations.
|
17726486 |
2007 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The mutation of C677T MTHFR was not independently associated with the prevalence of hypertension or BP levels although serum UA was.
|
16377929 |
2006 |