Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE Our findings suggest that C677T polymorphism of MTHFR seems to be a good marker for MTX-related toxicity in ALL. 30545275 2019
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE Association Between the 5,10-MTHFR 677C>T and RFC1 80G>A Polymorphisms and Acute Lymphoblastic Leukemia. 31499477 2019
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE We observed a significant decrease in risk for the C677T polymorphism (OR range=0.54-0.75, p<0.01) and a significant increase in risk for the A1298C polymorphism (OR range=1.28-2.52, p<0.05) in developing ALL for all genetic models. 31188929 2019
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE Use of MTHFR C677T polymorphism and plasma pharmacokinetics to predict methotrexate toxicity in patients with acute lymphoblastic leukemia. 29911750 2018
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE The association was detected significantly between MTHFR C677T polymorphism and ALL reducing susceptibility. 28062297 2017
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE There were no associations between MTHFR C677T or MTHFR A1298C polymorphisms and ALL susceptibility. 28646637 2017
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE The MTHFR C677T and A1298C genotypes were analyzed using allele discrimination tests with Taq-Man fluorescent probes.The MTHFR 677TT genotype was related to a 2-fold increase in risk of ALL (P = .014). 29390492 2017
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE In a case-control study of 203 patients with ALL and 246 controls and meta-analysis in the Indian population, we showed an insignificant association of MTHFR C677T and A1298C genotypes with childhood and adult ALL. 25115513 2015
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE The aims of this study were to (a) to determine the prevalence of seven common genetic polymorphisms including those that affect the folate and/or thiopurine metabolic pathways, i.e. cyclin D1 (CCND1-G870A), γ-glutamyl hydrolase (GGH-C452T), methylenetetrahydrofolate reductase (MTHFR-C677T and MTHFR-A1298C), thymidylate synthase promoter (TYMS-TSER), thiopurine methyltransferase (TPMT*3A and TPMT*3C) and inosine triphosphate pyrophosphatase (ITPA-C94A), in Caucasian (n = 94, age < 20) and Vietnamese (n = 141, age < 16 years) childhood ALL and (b) to assess the impact of a multilocus genetic risk score (MGRS) on relapse-free survival (RFS) using a Cox proportional-hazards regression model. 25099492 2015
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE No significant differences were found between patients with ALL and controls for the frequency of MTHFR C677T and A1298C alleles, genotypes, combined genotypes or haplotypes. 25629981 2015
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE The aim of our study was to investigate the influence of C677T and A1298C polymorphisms in methylenetetrahydrofolate reductase (MTHFR) gene on MTX-induced toxicity during treatment of children with ALL. 26528799 2015
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE Our results indicated that the MTHFR C677T T allele was a protective biomarker for childhood ALL in Taiwan, and the association was more significant in male patients and in patients 3.5 years of age or older at onset of disease. 25793509 2015
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE Our results suggest that the MTHFR C677T and A1298C polymorphisms may be potential biomarkers for ALL risk in Chinese populations, and studies with a larger sample size and wider population spectrum are required before definitive conclusions can be drawn. 25342508 2014
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE The effect of RFC G80A polymorphism in Cretan children with acute lymphoblastic leukemia and its interaction with MTHFR C677T and A1298C polymorphisms. 24237708 2014
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE Association of methylenetetrahytrofolate reductase (MTHFR) C677T and A1298C polymorphisms with the susceptibility of childhood acute lymphoblastic leukaemia (ALL) in Chinese population. 24476575 2014
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE Two polymorphisms of the gene encoding MTHFR, C677T and A1298C, alter MTHFR enzyme activity and may be associated with ALL relapse. 24637499 2014
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: effect on methotrexate-related toxicity in adult acute lymphoblastic leukaemia. 23183238 2013
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE This meta-analysis supports the idea that the MTHFR C677T genotype is associated with risk of ALL in Caucasians. 24377532 2013
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE Seventy-two children with ALL and 109 age- and sex-matched healthy children from Western Iran were screened for MTHFR C677T and A1298C variants by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). 22017305 2012
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE 5,10-methylenetetrahydrofolate reductase (MTHFR) variants, C677T and A1298C, have been reported to be associated with decreased risk of acute lymphoblastic leukemia (ALL). 22943282 2012
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE The aim of this case-control study was to evaluate the association of the C677T MTHFR gene polymorphism with acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL), chronic myeloid leukaemia (CML) and chronic lymphocytic leukaemia (CLL). 22441130 2012
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE The genetic association studies (GAS) that investigated the association between ALL and the MTHFR C677T and A1298C gene variants have produced contradictory or inconclusive results. 22094326 2012
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE Genotyping of MTHFR polymorphism, C677T particularly, prior to treatment for ALL is likely to be useful with the aim of tailoring MTX therapy and thus reducing the MTX-related toxicities. 22528943 2012
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE In the adult subgroup, there was no significant association between the C677T variant and ALL risk (Dominant model: OR(RE)=0.88, 95% CI: 0.45-1.72, p=0.72). 23061880 2012
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.100 GeneticVariation BEFREE A meta-analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children. 21495160 2012