|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
Methylenetetrahydrofolate Reductase Gene Polymorphisms (C677T and A1298C) and Hemorrhagic Stroke in Moroccan Patients.
|
29555401 |
2018 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
We aimed to investigate the association of Hcy concentration with intracranial atherosclerosis (ICAS) and extracranial AS (ECAS) in hypertensive patients without stroke in Chinese population and to explore modified effect of methylenetetrahydrofolate reductase (MTHFR) C677T on their relationship.
|
29330520 |
2018 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphisms Glu298Asp and C677T, affecting the eNOS and 5,10-MTHFR enzymes, respectively, and smoking, hypertension, and family history of stroke were associated with ischaemic stroke in young Mexican patients; this was not the case for the Thr325Ile, Ala147Thr, 4G/5G, and PLA1/A2 polymorphisms of the genes coding for fibrinolytic proteins and platelet receptors.
|
29526315 |
2018 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our major findings suggest that joint effects of the MTHFR C677T polymorphism and hypertension are consistent in predicting a significantly high risk of stroke.
|
27126505 |
2017 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homocysteine and Stroke Risk: Modifying Effect of Methylenetetrahydrofolate Reductase C677T Polymorphism and Folic Acid Intervention.
|
28360116 |
2017 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis suggests that MTHFR C677T genetic polymorphism is significantly associated with susceptibility to IS, which provides evidence supporting hyperhomocysteinemia as a risk factor for stroke.
|
26776436 |
2016 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
The frequently assessed hereditary thrombophilia mutations associated with stroke are methylenetetrahydrofolate reductase (MTHFR) c.677C>T, Factor V (F5) c.1691G>A (Leiden), and prothrombin (F2) c.20210G>A.
|
26522268 |
2016 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
We tested MTHFR C677T for association with stroke subtypes and white matter hyperintensities volume.
|
26839351 |
2016 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
We aimed to evaluate the effect of methylenetetrahydrofolate reductase (MTHFR) gene 677 C → T polymorphism, which was associated with a higher stroke risk and was common in the Chinese population, as well as homocysteine and estimated glomerular filtration rate (eGFR) levels on the risk of new-onset diabetes (NOD).
|
25700330 |
2015 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
We evaluated the relationship between hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and small-vessel disease (SVD) and atherosclerotic large-vessel disease (LVD) in stroke patients.
|
25031284 |
2014 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T polymorphism has been studied as a possible risk factor for a variety of common conditions including heart disease, stroke and hypertension.
|
24192663 |
2014 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
Meta-analysis of included studies suggested that TT genotype was obviously associated with increased risk of hemorrhagic str</span>oke (OR (TT versus CC) = 1.84, 95 % CI 1.45-2.34; OR (TT versus CT) = 1.53, 95 % CI 1.23-1.90; OR (TT versus CT/CC) = 1.64, 95 % CI 1.24-2.00) compared with CC or CT genotypes of MTHFR C677T polymorphism.
|
23184002 |
2013 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
After excluding articles that deviated from the Hardy-Weinberg equilibrium in controls and the key contributors to between-study heterogeneity, significant associations between the MTHFR C677T genetic polymorphism and the risk of hemorrhagic stroke were observed in dominant (Odds ratio [OR] 1.611, 95% confidence interval [CI] 1.336-1.942), codominant (OR 1.500, 95% CI 1.330-1.692), and recessive (OR 1.695, 95% CI 1.409-2.038) models.
|
23428159 |
2013 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
We tested this hypothesis by examining the influence of polymorphisms in methylenetetrahydrofolate reductase (MTHFR) (C677T) and prothrombin (F2) (G20210A) as risk factors for stroke in Morocco.
|
24132798 |
2013 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
Ten studies described MTHFR C677T (108 with TT genotype and 2018 with CC genotype) -homocysteine relationship and six studies (735 stroke cases and 713 controls) described homocysteine-ischemic stroke relationship.
|
23505425 |
2013 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
The variant methylenetetrahydrofolate reductase (MTHFR) C677T is associated with elevated homocysteine levels, cardiovascular disease and stroke, which supports a causal relationship between hyperhomocysteinemia and vascular disease.
|
23285280 |
2012 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
The obtained data indicate that heterozygosity for MTHFR C677T variant represents a possible important risk factor for pediatric stroke and suggest a different role of this gene variant in etiology of stroke in pediatric and adult patients.
|
22275392 |
2012 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further large-scale genetic studies of the association between MTHFR 677C→T and stroke in low folate settings are needed to distinguish effect modification by folate from small-study bias.
|
21803414 |
2011 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T was prevalent among patients with recurrent stroke.
|
21824561 |
2011 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T and A1298C polymorphisms and cerebral stroke in two twin gestations.
|
21113717 |
2011 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
This suggests that the MTHFR 677 C>T polymorphism played a minimal role or no role in stroke risk.
|
21270470 |
2011 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the association between different polymorphisms frequently found in young patients with cryptogenic stroke [methylenetetrahydrofolate reductase (MTHFR) C677T, factor II (prothrombin) G20210A, factor V G1691A (Leiden), nitric oxide synthase 3 (NOS3) intron 4 VNTR, and apolipoprotein E (APOE) epsilon4 gene] in patients with a cerebral infarct caused by spontaneous cervical artery dissection.
|
20446941 |
2010 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant association was found between MTHFR C677T and stroke recurrence or mortality.
|
19515015 |
2009 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
The MTHFR 677 C > T polymorphisms showed association with both homocysteine levels as well as stroke (P < 0.001).
|
19251185 |
2009 |
|
Cerebrovascular accident
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two siblings with a homozygous MTHFR C677T (G80A-RFC1) mutation and stroke.
|
18958479 |
2009 |