rs121912438, SOD1

N. diseases: 58
Disease: Muscle Weakness ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Muscle Weakness
CUI: C0151786
Disease: Muscle Weakness
0.020 GeneticVariation BEFREE We show in the SOD1(G93A) mouse model of ALS that recurrent exposure to restraint stress led to an earlier onset of astrogliosis and microglial activation within the spinal cord, accelerated muscular weakness, and a significant decrease in median survival (105 vs. 122 d) when compared to nonstressed animals. 21876068 2011
Muscle Weakness
CUI: C0151786
Disease: Muscle Weakness
0.020 GeneticVariation BEFREE Immunocytochemistry and Western blotting showed that a decrease of Hsp25 protein expression occurred in motoneurons of G93A mice prior to the onset of motoneuron death and muscle weakness. 15245475 2004