Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Neurodegenerative Disorders
CUI: C0524851
Disease: Neurodegenerative Disorders
0.050 GeneticVariation BEFREE Recently a tissue-specific and selective upregulation of the multidrug efflux transporter ABCB1 or P-glycoprotein (P-gp) in the spinal cord of both patients and the mutant SOD1-G93A mouse model of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease that prevalently kills motor neurons has been reported. 27158936 2016
Neurodegenerative Disorders
CUI: C0524851
Disease: Neurodegenerative Disorders
0.050 GeneticVariation BEFREE We used SOD1(G93A) mice as a model, which exhibit the motor neuron-specific neurodegenerative disease, amyotrophic lateral sclerosis. 23470532 2013
Neurodegenerative Disorders
CUI: C0524851
Disease: Neurodegenerative Disorders
0.050 GeneticVariation BEFREE We then analyzed molecular changes in microglia during neurodegenerative disease activation using the SOD1(G93A) mouse model of amyotrophic lateral sclerosis (ALS). 23850290 2013
Neurodegenerative Disorders
CUI: C0524851
Disease: Neurodegenerative Disorders
0.050 GeneticVariation BEFREE Transgenic mice carrying the G93A mutation of the superoxide dismutase 1 (SOD1) gene develop a neurodegenerative disease closely mimicking human ALS. 20450936 2010
Neurodegenerative Disorders
CUI: C0524851
Disease: Neurodegenerative Disorders
0.050 GeneticVariation BEFREE These results show that in the SOD1(G93A) model of neurodegenerative diseases, the concentration of brain glutamate (determined with (1)H-MRS) can be lowered by inhibiting in vivo the synthesis of glutamine with non-toxic doses of MSO. 20060132 2010