NEVUS, EPIDERMAL (disorder)
0.710
GeneticVariation
BEFREE
Nine of 33 (27%) EN harbored PIK3CA mutations; all cases showed the E545G substitution, which is uncommon in cancers.
17673550
2007
Malignant Neoplasms
0.010
GeneticVariation
BEFREE
The incidence of PIK3CA mutation is low in SCLC patients, and the pseudogene-positive alteration of A1634C is prone to occur in exon 9 of PIK3CA mutations in human cancers .
27629725
2016
Follicular thyroid carcinoma
0.010
GeneticVariation
BEFREE
In addition, an activating mutation (E545A ) in the PKI3CA oncogene was found in the FTC .
22136270
2011
Pain
×
CUI:
C0030193
Disease:
Pain
0.010
GeneticVariation
BEFREE
Next-generation sequencing analysis of 592 genes showed a missense mutation, p.E545A in PIK3CA, thus the patient was started on the mTOR inhibitor everolimus, in combination with exemestane, which controlled her pain ; however, the disease progressed aggressively.
29790419
2018
Liver carcinoma
0.800
CausalMutation
CLINVAR
Liver carcinoma
0.800
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
Liver carcinoma
0.800
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
NEVUS, EPIDERMAL (disorder)
0.710
CausalMutation
CLINVAR
Adenocarcinoma of pancreas
0.700
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
Mammary Neoplasms
0.700
CausalMutation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
Colorectal Neoplasms
0.700
CausalMutation
CLINVAR
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.
20453058
2010
Squamous cell carcinoma of lung
0.700
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
Mammary Neoplasms
0.700
CausalMutation
CLINVAR
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.
18725974
2008
melanoma
0.700
GeneticVariation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968
2014
Colorectal Neoplasms
0.700
CausalMutation
CLINVAR
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis.
20619739
2010
Colorectal Neoplasms
0.700
CausalMutation
CLINVAR
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.
15647370
2005
Colorectal Neoplasms
0.700
CausalMutation
CLINVAR
The PIK3CA gene is mutated with high frequency in human breast cancers.
15254419
2004
ovarian neoplasm
0.700
CausalMutation
CLINVAR
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic.
15647370
2005
Glioblastoma
0.700
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
Colorectal Neoplasms
0.700
CausalMutation
CLINVAR
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.
20453058
2010
Adenocarcinoma of prostate
0.700
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
Adenocarcinoma of pancreas
0.700
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
Brain Neoplasms
0.700
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
Transitional cell carcinoma of bladder
0.700
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016
Uterine Cervical Neoplasm
0.700
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011
2016