rs121913459, ABL1

N. diseases: 25
Disease: Acute lymphocytic leukemia ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.050 GeneticVariation BEFREE It suppressed primary Ph+ acute lymphatic leukemia-derived long-term cultures that either displayed nonmutational resistance or harbor the T315I. 25394714 2015
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.050 GeneticVariation BEFREE The BCR-ABL T315I kinase domain mutation is insensitive to dasatinib therapy for Philadelphia-positive acute lymphoid leukemia (Ph + ALL) patients. 22587422 2012
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.050 GeneticVariation BEFREE This cell line may provide a useful model for in vitro and in vivo cellular and molecular studies of BCR-ABL-positive ALL with T315I mutation. 20471447 2010
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.050 GeneticVariation BEFREE The objectives of this retrospective observational study were to estimate overall and progression-free survival for chronic myeloid leukemia in chronic-phase (CP), accelerated-phase (AP), or blastic-phase (BP) and Philadelphia chromosome-positive (Ph)(+) acute lymphoblastic leukemia (ALL) patients with T315I mutation. 19843886 2009
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.050 GeneticVariation BEFREE Three patients with T315I abl-mutated chronic myeloid leukemia (CML) or Philadelphia chromosome (Ph)-positive acute lymphocytic leukemia (ALL) have achieved clinical responses to doses of MK-04547 that are not associated with adverse events. 16990603 2007