|
Astrocytoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Of these, we recommend, OA,NOS and IDH1(R132H)-non-mt ODG,NOS to be our priority for performing 1p/19q co-deletion studies in comparison to IDH-mt ODG,NOS, and it would not be mandatory for astrocytoma.
|
28801347 |
2018 |
|
Astrocytoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
In the subgroup of 142 glioma patients characterized by IDH1-R132H status, METT/N ratio demonstrated a significant prognostic impact in IDH1-R132H wildtype astrocytomas and glioblastoma (P = 0.001).
|
29016947 |
2018 |
|
Astrocytoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Because many ALT tumors express the mutant isocitrate dehydrogenase IDH1 R132H, including all lower grade astrocytomas and secondary glioblastoma, we examined a hypothesized role for IDH1 R132H in driving the ALT phenotype during gliomagenesis.
|
29545335 |
2018 |
|
Astrocytoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Here, an in-depth characterization of IDH1 R132H mutations were assessed by immunohistochemistry in 55 paired primary-recurrent astrocytomas tissues, including 5 paired primary pilocytic astrocytoma (pPA, WHO grade I), 35 paired primary low grade astrocytoma (pLGA, WHO grade II and III) and 15 paired primary high grade astrocytoma (pHGA/ Glioblastoma, WHO grade IV).
|
28928859 |
2017 |
|
Astrocytoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
No IDH1-R132H mutation was detected in 2 of 2 (0%) astrocytomas by immunohistochemistry.
|
26990854 |
2016 |
|
Astrocytoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma.
|
25427834 |
2015 |
|
Astrocytoma
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
|
Astrocytoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
To study the putative expression patterns and clinical significance of Hsp27, we assessed the associations between Hsp27, R132H mutation of Isocitrate dehydrogenase1 (IDH1-R132H), Hypoxia-inducible factor subunit alpha (HIF-1 alpha), Carbonic anhydrase IX (CA IX), and patient prognosis in astrocytic gliomas.
|
24599602 |
2014 |
|
Astrocytoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Fractional anisotropy and ADC from DTI can noninvasively detect IDH1 R132H mutation in astrogliomas.
|
24557705 |
2014 |
|
Astrocytoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
As the presence of the p.R132H mutation in the IDH1 gene seems to be a more powerful prognostic marker than O(6)-methylguanine-DNA methyltransferase promoter status, we evaluated the presence of IDH1 mutation in Polish patients with astrocytoma, glioblastoma, oligoastrocytoma, ganglioglioma, oligodendroglioma, and ependymoma.
|
23934769 |
2014 |
|
Astrocytoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
We investigated the expression of Sox11 in 132 diffuse astrocytomas in relation to the regulator cell marker nestin, c-Met and IDH1-R132H, which have shown to be differentially expressed among the molecular subgroups of malignant gliomas, as well as to an inducer of astrocytic differentiation, that is, signal transducer and activator of transcription (p-STAT-3), clinicopathological features and survival.
|
23619925 |
2013 |
|
Astrocytoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
IDH1 R132H mutations occur in approximately 70% of astrocytomas and oligodendroglial tumors.
|
19798509 |
2009 |
|
Astrocytoma
|
|
0.800 |
GeneticVariation
|
CLINVAR |
IDH1 R132H mutations occur in approximately 70% of astrocytomas and oligodendroglial tumors.
|
19798509 |
2009 |
|
Astrocytoma
|
|
0.800 |
GeneticVariation
|
CLINVAR |
Furthermore, IMab-1 specifically stained the IDH1(R132H)-expressing cells in astrocytomas in immunohistochemistry, whereas it did not react with IDH1(R132H)-negative primary glioblastoma sections.
|
19818334 |
2009 |
|
Astrocytoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Furthermore, IMab-1 specifically stained the IDH1(R132H)-expressing cells in astrocytomas in immunohistochemistry, whereas it did not react with IDH1(R132H)-negative primary glioblastoma sections.
|
19818334 |
2009 |