|
oligodendroglioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The reported two cases were initially diagnosed as oligodendroglioma with 1p/19q-codeletion and mutation of <i>isocitrate dehydrogenase 1 (IDH1)</i>-R132H.
|
31508376 |
2019 |
|
oligodendroglioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The histopathological findings of his surgical specimen revealed characteristics of a low-grade glioma with an IDH1 c.395G>A (R132H) mutation and 1p/19q codeletion, which led to a definitive diagnosis of oligodendroglioma.
|
29224049 |
2018 |
|
oligodendroglioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The R132H mutation in IDH1 was found in 60.5% (23/38) of patients in the AA cohort (Groups 2 and 4) and 20.0% (13/65) of patients from our GBM cohort (Groups 3 and 5), whereas all patients with ODG (Group 1) had a mutation either in IDH1 (n = 62) or IDH2 (n = 3).
|
28851427 |
2017 |
|
oligodendroglioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
IDH1(R132) mutation was most frequent in oligodendrogliomas (57/62, 91.9%), with IDH1(R132H) mutation as the most frequent mutation form.
|
27780605 |
2016 |
|
oligodendroglioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the relationship between 3 hypoxic markers, carbonic anhydrase-9 (CA-9), hypoxia-inducible factor (HIF)-1α, and HIF-2α and the traditional genetic markers, deletions of chromosomes 1p and 19q and Isocitrate dehydrogenase 1 (IDH1) R132H mutation in oligodendrogliomas.
|
26960282 |
2016 |
|
oligodendroglioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
IDH1-R132H and 1p19q loss were found only in 12 out of the 13 oligodendrogliomas (P<0.0001).
|
27389560 |
2016 |
|
oligodendroglioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Three GBM-O samples had IDH1 (p.R132H) mutations; two of these also demonstrated 1p/19q co-deletion and had a proneural transcriptional profile, a molecular signature characteristic of oligodendroglioma.
|
26757882 |
2016 |
|
oligodendroglioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an "integrated" diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma.
|
25427834 |
2015 |
|
oligodendroglioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K).
|
25277207 |
2014 |
|
oligodendroglioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, oligodendrogliomas with classic histology occur in the pediatric population but lack 1p19q codeletion and IDH1 (R132H) mutations in most instances.
|
24805856 |
2014 |
|
oligodendroglioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We present 9 pediatric cases of such diffuse leptomeningeal neuroepithelial tumors (DLNT), 8 with assessment of 2 common genetic alterations seen in oligodendrogliomas, 1p and 19q chromosomal deletions and isocitrate dehydrogenase-1 (IDH1) R132H mutations.
|
23588371 |
2013 |
|
oligodendroglioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This glioma xenograft is the first to display a pure oligodendroglioma histology and expression of R132H.
|
23527265 |
2013 |
|
oligodendroglioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG.
|
24252742 |
2013 |
|
oligodendroglioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We evaluated nuclear cMYC protein levels and IDH1 (R132H) by immunohistochemistry in patients with oligodendroglioma/oligoastrocytomas (n = 20), astrocytomas (grade II) (n = 19), anaplastic astrocytomas (n = 21) or glioblastomas (n = 111).
|
23934175 |
2013 |
|
oligodendroglioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The mutation analysis performed on the latter case with DNA separately sampled from the oligodendroglioma- like area and the astrocytoma-like area detected IDH1 G395A in both areas.
|
22385787 |
2012 |