rs1229984, ADH1B

N. diseases: 83
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Alcohol abuse
CUI: C0085762
Disease: Alcohol abuse
0.030 GeneticVariation BEFREE Given the logistic and ethical constraints that would be associated with a trial of alcohol use to prevent depression, we aimed to complete a Mendelian randomization study to determine if a genetic polymorphism associated with alcohol abuse and dependence (ADH1B rs1229984 G-->A) contributed to modulate the risk of depression in a community-derived cohort of older men. 24018899 2014
Alcohol abuse
CUI: C0085762
Disease: Alcohol abuse
0.030 GeneticVariation BEFREE We genotyped the rs1229984 G→A variant of the alcohol dehydrogenase 1B (ADH1B) gene, which is associated with lower prevalence of alcohol abuse and dependence. 24553426 2014
Alcohol abuse
CUI: C0085762
Disease: Alcohol abuse
0.030 GeneticVariation BEFREE Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]). 21917409 2012