|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis indicated that the ERCC1 rs3212986 polymorphism and 2 polymorphisms in ERCC2 gene (rs13181 and rs1799793) contributed to the susceptibility of glioma.
|
28514298 |
2017 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Additionally, subgroup analyses of 8 SNPs by ethnicity indicated that the mutation of rs13181, rs1800067 were apparently protective factors of glioma among Asians, while the mutation of rs13181 was a risk factors of glio</span>ma in Caucasians.
|
26843108 |
2017 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
ERCC2 rs13181 polymorphism association with glioma susceptibility in a Chinese population.
|
27323065 |
2016 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
No significant association was observed between ERCC2 rs13181 polymorphisms and glioma risk.
|
25867436 |
2015 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis strongly suggested that ERCC2 rs13181 was associated with a higher susceptibility to glioma in the Chinese population.
|
26505408 |
2015 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The combined results demonstrated rs131</span>81 to be significantly associated with g</span>lioma risk (G allele versus T allele: OR=1.15, 95% CI=1.05-1.26, P=0.002; dominant model: OR=1.22, 95% CI=1.07-1.39, P=0.002; recessive model: OR=1.18, 95% CI=0.98-1.41, P=0.070).
|
24969862 |
2014 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
And the TT genotype of ERCC2 Lys751Gln polymorphism may decrease the risk of glioma in the Caucasian population.
|
24763305 |
2014 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the results of our study suggest that the rs25487, rs25489, rs1799793, and rs13181 SNPs are associated with an increased risk of glioma.
|
24634177 |
2014 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We found that SNPs rs3212986 (odds ratio [OR] = 1.35 (1.08-1.68), P = .008), rs13181 (OR = 1.18 (1.06-1.31), P = .002), and rs25487 (OR = 1.12 (1.03-1.22), P = .007) in DNA repair genes ERCC1, ERCC2 (XPD), and XRCC1 may increase the risk of glioma, while polymorphisms rs1136410 (OR = 0.78 (0.68-0.89), P = .0004) and rs12917 (OR = 0.84 (0.73-0.96), P = .01) in PARP1(ADPRT) and MGMT are associated with decreased susceptibility to glioma.
|
24500421 |
2014 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of this meta-analysis indicate that the AA genotype of ERCC1 C8092A may be associated with a higher risk of adult glioma than the CA and CC genotypes and that the risk allele of ERCC2 K751Q confers a significant susceptibility to adult glioma, especially in Asian populations.
|
24254311 |
2014 |
|
Glioma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We genotyped constitutive variants ERCC1 C8092A and ERCC2 K751Q and R156R in approximately 450 adults with glioma and 500 controls from two independent population-based series, uniformly reviewed patients' tumors to determine histopathologic category, and determined a variety of tumor markers among astrocytic tumors.
|
16212814 |
2005 |