|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
In search of genetic markers of myocardial infarction (MI) risk, which have prognostic significance for Russians, we performed a replication study of MI association with genetic variants of <i>PCSK9</i> (rs562556), <i>APOE</i> (epsilon polymorphism, rs7412 and rs429358), <i>LPL</i> (rs320), <i>MTHFR</i> (rs1801133), <i>eNOS</i> (rs2070744), and the 9p21 region (rs1333049) in 405 patients with MI and 198 controls.
|
29340220 |
2019 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, rs1333049 is associated with myocardial infarction in the white population of Western Siberia (Russia).
|
31330999 |
2019 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Among an inception cohort of those who experienced MI </span>during follow-up, the risk allele of r</span>s1333049 was associated with a decreased risk of subsequent mortality (HR = 0.90, p-value = 3.2×10-3).
|
26950853 |
2016 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Large-scale genome-wide association studies (GWAS) have revealed that rs10757278 polymorphism (or its proxy rs1333049) on chromosome 9p21 is associated with myocardial infarction (MI) susceptibility in individuals of Caucasian ancestry.
|
26006241 |
2015 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
The current study demonstrates a strong association of the ANRIL SNP (rs1333049) with MI as well as familial hypercholesterolemia patients in a northern Pakistani population and could be used as a useful genetic marker for the screening of MI in the general Pakistani population.
|
23266621 |
2013 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
The single nucleotide polymorphism (SNP), rs1333049 on chromosome 9p21.3 has been strongly associated with CAD and myocardial infarction.
|
23787071 |
2013 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the case-control study, only haplotypes at 1 block tagged by rs1333049 associated with CAD more so than MI.
|
23729007 |
2013 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genome-wide significant associations with CAC for SNPs on chromosome 9p21 near CDKN2A and CDKN2B (top SNP: rs1333049; P=7.58×10(-19)) and 6p24 (top SNP: rs9349379, within the PHACTR1 gene; P=2.65×10(-11)) replicated for CAC and for MI.
|
22144573 |
2011 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Specific polymorphisms (rs7865618, rs1537378, rs7857345, rs1333049) were identified as independent predictors of MI in multivariable models adjusted for conventional cardiovascular risk factors.
|
21511257 |
2011 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
After having confirmed that the at-risk C allele of rs1333049 was associated with index ACS in the UK and Belgian populations, we found that the rs1333049 at-risk C allele was significantly and independently associated with recurrent MI [age- and gender-adjusted hazard ratio (HR) 1.48, CI = 1.00-2.19, P = 0.048; and multivariable-adjusted HR 1.47, CI = 0.99-2.18; P = 0.053] and with recurrent MI or cardiac death (age- and gender-adjusted HR 1.58, CI = 1.00-2.48; P = 0.045; and multivariable adjusted HR 1.49, CI = 1.03-1.98; P = 0.028) within 6 months after an index ACS.
|
20231156 |
2010 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
As proof of principle, we meta-analyzed risk variants at 9p21 and found that rs1333049 confers a 29% increase in risk for MI per copy (P=2×10⁻²⁰).
|
20923989 |
2010 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study demonstrates an association of rs1333049 polymorphism locus on chromosome 9p21 with risk for MI, but not with post-MI prognosis in Han Chinese.
|
19548844 |
2009 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common variant at chromosome 9p21 (tagged by the rs1333049 or rs10757278 single-nucleotide polymorphism) is strongly associated with myocardial infarction and major arterial aneurysms.
|
20031606 |
2009 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
Although the underlying mechanisms are not clearly understood, the previously reported association between the 2 SNPs (rs1333049 and rs17465637) and MI was reproduced in this Japanese sample.
|
18654002 |
2008 |
|
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism (SNP), rs1333049, representing the 9p21.3 locus, was genotyped in 7 case-control studies involving a total of 4645 patients with myocardial infarction or CAD and 5177 controls.The mode of inheritance was determined.
|
18362232 |
2008 |