Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
The HNF1A G319S variant is associated with incident type 2 diabetes in Aboriginal Canadians.
|
21208426 |
2011 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
In an Aboriginal Canadian population, a private polymorphism, HNF1A G319S, was associated with increased prevalence of type 2 diabetes.
|
20716378 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
The G319S HNF1A variant is associated with an increased risk of type 2 diabetes in the Canadian Oji-Cree population.
|
18586913 |
2008 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
Progress to date in the molecular genetics of T2DM in youth is limited to one population, the Oji-Cree Native Canadians, where the private variant - G319S - a variant of HNF1A strongly predisposes to diabetes in children as well as in adults.
|
17991132 |
2007 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
The ORs for type 2 diabetes were similar ( approximately 5-fold) for subjects with either the presence of HTGW or the private HNF1A G319S mutation.
|
16276364 |
2006 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
The risk of Type 2 diabetes was similar (approximately five-fold increased) for subjects with either the presence of the modified metabolic syndrome or the private HNF1A G319S mutation.
|
16241915 |
2005 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
A common variant, G319S, private to the Oji-Cree population, predisposes to type 2 diabetes, but the role of common HNF1alpha variation in European populations has not been comprehensively assessed.
|
16046319 |
2005 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
Furthermore, G319S had specificity and positive predictive value of 97% and 95%, respectively, for developing type 2 diabetes by age 50.
|
12726923 |
2003 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
The demonstration of a functional consequence for HNF1A G319S provides a mechanistic basis for its strong association with Oji-Cree type 2 diabetes and its unparalleled specificity for diabetes prediction in these people, in whom diabetes presents a significant public health dilemma.
|
11904371 |
2002 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
Because HNF-1alpha is involved in the transcription of several apolipoprotein genes, we tested for an association between the private HNF1A G319S variant and plasma lipoproteins in a sample of 55 unrelated Oji-Cree subjects with type 2 diabetes and 175 unrelated Oji-Cree subjects without type 2 diabetes.
|
10634821 |
2000 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
Among the Oji-Cree of northern Ontario, we previously identified a novel variant in the HNF1A gene, namely G319S, that was strongly associated with type 2 diabetes.
|
10843190 |
2000 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
GeneticVariation
|
BEFREE |
Disparity between association and linkage analysis for HNF1A G319S in type 2 diabetes in Canadian Oji-Cree.
|
10807546 |
2000 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.800 |
SusceptibilityMutation
|
CLINVAR |
|
|
|
Diabetes
|
|
0.090 |
GeneticVariation
|
BEFREE |
The influence of exposure to diabetes in utero and the HNF-1α G319S polymorphism on the metabolic phenotype of youth with T2DM at diagnosis is unknown.
|
27087001 |
2016 |
Diabetes Mellitus
|
|
0.090 |
GeneticVariation
|
BEFREE |
The influence of exposure to diabetes in utero and the HNF-1α G319S polymorphism on the metabolic phenotype of youth with T2DM at diagnosis is unknown.
|
27087001 |
2016 |
Diabetes Mellitus
|
|
0.090 |
GeneticVariation
|
BEFREE |
When participants were stratified by baseline smoking status, HNF1A G319S carriers who were active smokers had increased risk of developing diabetes (OR 6.91 [95% CI 3.38-14.12]), while the association was attenuated to non-significance among non-smokers (1.11 [0.40-3.08]).
|
21208426 |
2011 |
Diabetes
|
|
0.090 |
GeneticVariation
|
BEFREE |
All of the 7 offspring with diabetes have 1 or 2 copies of the G319S polymorphism.
|
21429061 |
2011 |
Diabetes
|
|
0.090 |
GeneticVariation
|
BEFREE |
When participants were stratified by baseline smoking status, HNF1A G319S carriers who were active smokers had increased risk of developing diabetes (OR 6.91 [95% CI 3.38-14.12]), while the association was attenuated to non-significance among non-smokers (1.11 [0.40-3.08]).
|
21208426 |
2011 |
Diabetes Mellitus
|
|
0.090 |
GeneticVariation
|
BEFREE |
All of the 7 offspring with diabetes have 1 or 2 copies of the G319S polymorphism.
|
21429061 |
2011 |
Diabetes
|
|
0.090 |
GeneticVariation
|
BEFREE |
We aimed to investigate whether CRP was mediating the association between HNF1A G319S and type 2 diabetes in an Aboriginal Canadian population with a high prevalence of diabetes.
|
20716378 |
2010 |
Diabetes Mellitus
|
|
0.090 |
GeneticVariation
|
BEFREE |
We aimed to investigate whether CRP was mediating the association between HNF1A G319S and type 2 diabetes in an Aboriginal Canadian population with a high prevalence of diabetes.
|
20716378 |
2010 |
Diabetes Mellitus
|
|
0.090 |
GeneticVariation
|
BEFREE |
A combination of abnormal splicing and reduced activity of the G319S protein may explain the diabetes susceptibility.
|
18586913 |
2008 |
Diabetes
|
|
0.090 |
GeneticVariation
|
BEFREE |
A combination of abnormal splicing and reduced activity of the G319S protein may explain the diabetes susceptibility.
|
18586913 |
2008 |
Diabetes Mellitus
|
|
0.090 |
GeneticVariation
|
BEFREE |
Sigmoidal modeling showed that each dose of the G319S allele accelerated the median age of diabetes onset by about 7 yr.
|
12726923 |
2003 |
Diabetes
|
|
0.090 |
GeneticVariation
|
BEFREE |
Sigmoidal modeling showed that each dose of the G319S allele accelerated the median age of diabetes onset by about 7 yr.
|
12726923 |
2003 |