|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP) in CHRNA5 (rs16969968, change from an aspartic acid [D] to asparagine [N] at position 398 of the human α5 nicotinic acetylcholine receptor subunit) has been associated with increased risk for nicotine dependence.
|
29573323 |
2018 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was a trend towards significance between rs16969968 and smoking behavior (smoking status [P = 0.05], nicotine dependence [AA > AG > GG; P = 0.08]).
|
29688464 |
2018 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study characterized the CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms in a Mexican population and its association with nicotine dependence, LC, and COPD.
|
29993116 |
2018 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
To assess its impact, we regressed the lifetime FTND latent variable on well-established factors associated with nicotine dependence (quitting smoking and the nicotinic acetylcholine receptor gene [CHRNA5] variant rs16969968, separately), and we observed that the regression coefficients were unchanged between models with and without adjustment for measurement non-invariance.
|
29438887 |
2018 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results indicate rs4887074 is associated with CHRNB4 expression, and along with two regulatory variants of CHRNA3 and CHRNA5, modulates the effect of rs16969968 on nicotine dependence risk.
|
30453884 |
2018 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
Haplotype/diplotype analysis of rs880395 and rs1948 plus rs16969968 (a nonsynonymous CHRNA5 risk variant) in GWAS (COGEND, UW-TTURC, SAGE) yields a nicotine dependence risk profile only partially captured by rs16969968 alone.
|
27758088 |
2017 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
SNP rs16969968 as a Strong Predictor of Nicotine Dependence and Lung Cancer Risk in a North Indian Population
|
29172281 |
2017 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
Studies link a gene cluster encoding for α3β4α5-D398N nicotinic acetylcholine receptors to lung cancer risk as well as link a second mutation in this cluster to an increased risk for nicotine dependence.
|
28045487 |
2017 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
The common nonsynonymous variant rs16969968 in the α5 nicotinic receptor subunit gene (CHRNA5) is the strongest genetic risk factor for nicotine dependence in European Americans and contributes to risk in African Americans.
|
26239294 |
2016 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our top result was rs16969968 (P = 1.7 × 10(-14)) in CHRNA5, a locus previously associated with COPD susceptibility and nicotine dependence.
|
26771213 |
2016 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study showed a low to moderate level of ND in the Kashubians, influenced by age, sex, as well as the CHRNA5 rs16969968 variant.
|
25652844 |
2015 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
Haplotype analyses showed that rs11636753-G and the functional rs16969968-A alleles together increased risk of nicotine dependence more than each variant alone: P = 3.1 × 10(-12), OR (95% CI) = 1.32 (1.22-1.43).
|
26220977 |
2015 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
Minor allele carriers at rs16969968 in the nicotinic acetylcholine receptor α5 subunit gene (CHRNA5) have been shown to exhibit both reduced cognitive control and greater nicotine dependence.
|
24934182 |
2014 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated six variants known to influence nicotine addiction or alcohol metabolism, including rs16969968 (CHRNA5), rs578776 (CHRNA3), rs1229984 (ADH1B), rs698 (ADH1C), rs1573496 (ADH7), and rs4767364 (ALDH2).
|
24505444 |
2014 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
The analysis revealed a candidate SNP from CHRNA5, rs16969968, associated with both ND and AD, and replicated the findings in an independent dataset with a P-value of 1.06 × 10(-03) .
|
23334941 |
2013 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggest a role for rs16969968 in nicotine addiction, and the novel association with snus strengthens this observation.
|
23443019 |
2013 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
Significant interactive effects of childhood adversity and rs16969968 genotype were observed in men (ND: OR=1.80, 95% CI=1.18-2.73, P=0.0044; FTND: OR=1.79, 95% CI=1.11-2.88, P=0.012).No interaction was found in women.
|
22012472 |
2012 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
We assessed the role of rs16969968 on brain functional MRI (fMRI) reactivity to smoking cues by studying nicotine dependent women with the nicotine dependence 'risk' allele (A allele, N=14) and without the 'risk' allele (G/G smokers, N=10).
|
21764527 |
2012 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
A rare variant of chromosomal region 15q25.1, marked by rs16969968 (substitution 1354G>A in CHRNA5), was found to be associated with increased lung cancer and nicotine-dependence risk.
|
21955800 |
2012 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
Carriers of both the rs16969968-AA and rs6495308-TT genotypes had approximately twofold greater odds for ND defined using CPD or TTF.
|
22223462 |
2012 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
Strong evidence demonstrates that nicotine dependence is associated with 4 genetic variants rs16969968, rs6474412, rs3733829, and rs1329650 in large-scale Genome-Wide Association Studies.
|
22102629 |
2012 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
The enhancer region and the nonsynonymous polymorphism rs16969968 generate three main haplotypes that alter the risk of developing nicotine dependence.
|
20700147 |
2011 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
The purpose of this study was to analyse the association of smoking status and smoking-related phenotypes (included nicotine dependence) with 17 candidate genetic variants: CYP2A6*1×2, CYP2A6*2 (1799T>A) [rs1801272], CYP2A6*9 (-48T>G) [rs28399433], CYP2A6*12, CYP2A13*2 (3375C>T) [rs8192789], CYP2A13*3 (7520C>G), CYP2A13*4 (579G>A), CYP2A13*7 (578C>T) [rs72552266], CYP2B6*4 (785A>G), CYP2B6*9 (516G>T), CHRNA3 546C>T [rs578776], CHRNA5 1192G>A [rs16969968], CNR1 3764C>G [rs6928499], DRD2-ANKK1 2137G>A (Taq1A) [rs1800497], 5HTT LPR, HTR2A -1438A>G [rs6311] and OPRM1 118A>G [rs1799971].
|
22046326 |
2011 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
Peer smoking had a substantially lower effect on nicotine dependence among those with the high-risk AA genotype at the functional SNP rs16969968 (CHRNA5) than among those with lower-risk genotypes.
|
20840187 |
2010 |
|
Nicotine Dependence
|
|
0.100 |
GeneticVariation
|
BEFREE |
We replicated several previous findings, including associations between rs16969968 and nicotine dependence (P=0.002) and cocaine dependence (P=0.02), with opposite risk alleles for each substance.
|
20485328 |
2010 |