Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Cirrhosis
CUI: C1623038
Disease: Cirrhosis
0.090 GeneticVariation BEFREE The frequencies of HD genotype of H63D mutation were significantly increased in HCC patients compared to control group and to cirrhosis group. 21925577 2011
Cirrhosis
CUI: C1623038
Disease: Cirrhosis
0.090 GeneticVariation BEFREE Similarly, hepatitis C patients with H63D homozygosity had a higher likelihood of cirrhosis compared with those with H63D wild type (OR: 2.35, CI : 0.19-28.5, P = 0.52). 15780041 2005
Cirrhosis
CUI: C1623038
Disease: Cirrhosis
0.090 GeneticVariation BEFREE C282Y and H63D mutations do not appear to be associated with an increased risk of HCC in patients with cirrhosis. 12865278 2003
Cirrhosis
CUI: C1623038
Disease: Cirrhosis
0.090 GeneticVariation BEFREE By multivariate logistic regression analysis the odds ratio for the development of advanced fibrosis or cirrhosis (F2-F4) was 2.5 for HCV-infected patients carrying a heterozygous C282Y mutation and 4.8 for HCV-infected patients with C282Y/H63D and C282Y/S65C compound heterozygosity. 14557859 2003
Cirrhosis
CUI: C1623038
Disease: Cirrhosis
0.090 GeneticVariation BEFREE C282Y or H63D heterozygosity is an independent risk factor for liver fibrosis and cirrhosis in HCV infected individuals. 12586300 2003
Cirrhosis
CUI: C1623038
Disease: Cirrhosis
0.090 GeneticVariation BEFREE HFE mutations (C282Y and H63D) were assessed in 162 consecutive patients (131 men/31 women) with HCC.A total of 159 patients had cirrhosis. 12591066 2003
Cirrhosis
CUI: C1623038
Disease: Cirrhosis
0.090 GeneticVariation BEFREE The aim of this study was to investigate the association between HFE gene mutations (C282Y, H63D) and hepatocellular carcinoma in patients with alcoholic and virus-related cirrhosis. 12003382 2002
Cirrhosis
CUI: C1623038
Disease: Cirrhosis
0.090 GeneticVariation BEFREE The possibility of cirrhosis-associated hemosiderosis secondary to an iron metabolism abnormality associated with the H63D mutation of the HFE gene is proposed. 11473464 2001
Cirrhosis
CUI: C1623038
Disease: Cirrhosis
0.090 GeneticVariation BEFREE The aims of this study were to define the prevalence of the mutations 845G --> A and 187C --> G (C282Y and H63D) in the HFE gene associated with hereditary hemochromatosis in Italian patients with hepatocellular carcinoma occurring in cirrhosis and to analyze the interaction between these mutations and other established risk factors for hepatocellular carcinoma. 11500061 2001