rs1799983, NOS3

N. diseases: 246
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Arteriosclerosis
CUI: C0003850
Disease: Arteriosclerosis
0.100 GeneticVariation BEFREE The NOS3 G894T polymorphic variant also correlated with atherosclerosis, an association probably mediated by the traditional risk factors for CVD. 29948131 2018
Arteriosclerosis
CUI: C0003850
Disease: Arteriosclerosis
0.100 GeneticVariation BEFREE In the present study, we analyzed the G894T polymorphism of the eNOS gene in groups of individuals diagnosed with atherosclerosis and in a control group. 28481400 2017
Arteriosclerosis
CUI: C0003850
Disease: Arteriosclerosis
0.100 GeneticVariation BEFREE We investigated associations between the NOS3 Glu298Asp SNP (rs1799983) and hypertension, as well as the interaction between NOS3 genotypes and dietary fat intake using data from baseline examination in white and African American participants in the Atherosclerosis Risk in Community (ARIC) study. 19960019 2010
Arteriosclerosis
CUI: C0003850
Disease: Arteriosclerosis
0.100 GeneticVariation BEFREE All 1085 incident coronary heart disease cases, all 300 incident ischemic stroke cases, and 1065 reference individuals from the Atherosclerosis Risk in Communities study were genotyped for the T-786C and E298D polymorphisms in NOS3. 17108813 2006
Arteriosclerosis
CUI: C0003850
Disease: Arteriosclerosis
0.100 GeneticVariation BEFREE Atherosclerosis and the Glu298Asp polymorphism of the eNOS gene in white patients with end-stage renal disease. 16364824 2005
Arteriosclerosis
CUI: C0003850
Disease: Arteriosclerosis
0.100 GeneticVariation BEFREE This suggests that the association of the Glu(298)-->Asp genotype with atherosclerosis in the carotid arteries is site-specific and is modified by overall cardiovascular risk. 16060860 2005
Arteriosclerosis
CUI: C0003850
Disease: Arteriosclerosis
0.100 GeneticVariation BEFREE To assess the role of the endothelial nitric oxide synthase (eNOS) gene variants as risk factors for early atherosclerosis, we sought to investigate whether two polymorphisms located in the exon 7 (Glu298-->Asp) and in the promoter region (T-786-->C) of the eNOS gene were associated with functional changes in the endothelium and carotid intima-media thickness (IMT). 15073390 2004
Arteriosclerosis
CUI: C0003850
Disease: Arteriosclerosis
0.100 GeneticVariation BEFREE Our results suggest that there is no association of the Glu298Asp polymorphism with coronary or carotid atherosclerosis or forearm vascular reactivity in these populations recruited in a country with a rather high risk for atherosclerosis. 12641536 2003
Arteriosclerosis
CUI: C0003850
Disease: Arteriosclerosis
0.100 GeneticVariation BEFREE Endothelial nitric oxide synthase gene Glu298Asp polymorphism and blood pressure, left ventricular mass and carotid artery atherosclerosis in a population-based cohort. 11905585 2002
Arteriosclerosis
CUI: C0003850
Disease: Arteriosclerosis
0.100 GeneticVariation BEFREE Reduced vasorelaxations were associated with increased number of clinical risk factors for atherosclerosis (r = - 0.54, P < 0.001), whereas the Glu298Asp variant was not associated with any differences in contractions to phenylephrine, NO-mediated vasorelaxations to acetylcholine, bradykinin or calcium ionophore, or relaxations to the NO donor sodium nitroprusside. 11298374 2001
Arteriosclerosis
CUI: C0003850
Disease: Arteriosclerosis
0.100 GeneticVariation BEFREE We examined associations between the endothelial nitric oxide synthase (eNOS) gene Glu-298-->Asp (894G-->T) mutation and the occurrence and severity of angiographically defined coronary artery disease (CAD). eNOS mediates basal vascular wall nitric oxide production, and altered nitric oxide production has been implicated in atherosclerosis. 10475066 1999