|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs1799983-T and rs891512-A alleles and interaction between rs1799983 and smoking were all risk factors of CHD.
|
31567371 |
2020 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further subgroup analyses according to ethnicity of participants revealed that the rs1799983 and rs2070744 polymorphisms were significantly associated with the risk of coronary artery disease in both Caucasians and Asians, whereas the rs869109213 polymorphism was only associated with the risk of coronary artery disease in Caucasians.
|
30789045 |
2019 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, we also found that the rs1799983 polymorphism was significantly associated with the susceptibility to peripheral artery disease, whereas the rs2070744 polymorphism was significantly associated with the susceptibility to coronary artery disease in DM patients.
|
30140993 |
2018 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the eNOS G894T gene polymorphism was associated with the occurrence and development of CHD in young people.
|
29359785 |
2018 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association Patterns of Endothelial Nitric Oxide Synthase Gene (NOS3) Variant Glu298Asp with Blood Pressure and Serum Lipid Levels in Subjects with Coronary Artery Disease from Pakistan.
|
28620990 |
2017 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The objective of this study is to understand the genetic mechanism of eNOS -786T/C, Intron 4b/4a and 894G/T polymorphisms/haplotypes in the development of CHD and to identify individuals having coronary risk factors among the FDRS of CHD patients by comparing them with the general population.
|
27613099 |
2016 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
AF patients with rs1799983 variants were more likely to have coronary artery disease or stroke than those without genetic variant at this gene (31.0% vs. 17.3%, p=0.004).
|
26256966 |
2015 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
On the basis of present results, it can be concluded that rs1799</span>983 is strongly associated with coronary artery disease in our population and TT genotype of this polymorphism enhanced the risk of coronary artery disease in Pakistani population.
|
25057159 |
2015 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Effects of eNOS rs1799983 and ACE rs4646994 polymorphisms on the therapeutic efficacy of salvianolate injection in Chinese patients with coronary heart disease.
|
24827774 |
2014 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two functional single nucleotide polymorphisms (SNPs) (T-786C: rs2070744 and G894T: rs1799983) and one tagging SNP (rs7830) were evaluated in our study, and we assessed their association with the risk of CHD.
|
24938467 |
2014 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We enrolled 1977 Japanese type 2 diabetic subjects without history of CVD (males 66.1%, 59.5 ± 10.0 years old), determined their genotypes regarding glutamate-cysteine ligase modifier subunit (GCLM) C-588T, manganese superoxide dismutase (SOD2) Val16Ala, endothelial nitric oxide synthase (NOS3) G894T, NAD(P)H oxidase p22phox (CYBA) C242T, and myeloperoxidase (MPO) G-463A polymorphisms, and prospectively evaluated the association between these polymorphisms and CHD events.
|
24933031 |
2014 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results indicated that the eNOS Glu298Asp polymorphism is a risk factor for developing CHD, particularly in the Asian population.
|
23443250 |
2013 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis indicated that eNOS 894G/T polymorphism may play an important role in CHD development among Asia population.
|
22417945 |
2012 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of endothelial nitric oxide synthase gene variant (G894T) with coronary artery disease in Western Iran.
|
21602253 |
2012 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of endothelial dysfunction with endothelin, nitric oxide and eNOS Glu298Asp gene polymorphism in coronary artery disease.
|
22045428 |
2011 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease.
|
21816783 |
2011 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism Glu298Asp of endothelial nitric oxide (eNOS) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial.
|
20083095 |
2010 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Relationship between hemorheology and Glu(298)Asp polymorphism of endothelial nitric oxide synthase gene in patients with coronary artery disease.
|
19434512 |
2010 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
This study, for the first time, suggests an independent association of 894G>T and -786T>C polymorphisms of endothelial nitric oxide synthase gene with coronary artery disease in a Saudi population.
|
20470943 |
2010 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data indicate that the eNOS 894G>T polymorphism is associated with increased CHD risk.
|
18844489 |
2008 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The eNOS -786T>C (odds ratio [OR]; 1.61, 95% confidence interval [CI]; 0.97-2.69), 894G>T (OR; 1.12, 95% CI; 0.65-1.92) and 4a4b (OR; 1.44, 95% CI; 0.87-2.39) polymorphisms were not an independent predisposition factor to coronary artery disease.
|
16842840 |
2007 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Endothelial nitric oxide synthase G894T gene polymorphism in Chilean subjects with coronary artery disease and controls.
|
16616056 |
2006 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In Caucasians, association between E298D genotype and risk of coronary heart disease was significantly modified by current smoking status (interaction P=0.013), with the highest risk observed in smokers carrying the variant D298 allele relative to nonsmokers carrying two E298 alleles (adjusted hazard rate ratio 2.07, 95% confidence interval 1.39-3.07).
|
17108813 |
2006 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, there was evidence that small studies with more striking results could affect the associations of the Glu298Asp and -786T>C polymorphisms with coronary heart disease.
|
17018701 |
2006 |
|
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We systematically examined the associations of eight variants of the eNOS gene (two potentially functional variants [-786T>C and Glu298Asp] and six tagging single nucleotide polymorphisms) with CHD risk in a large cohort of diabetic patients.
|
16804086 |
2006 |