rs1799983, NOS3

N. diseases: 246
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.100 GeneticVariation BEFREE As for vascular complications in DM, significant associations with the susceptibility to diabetic nephropathy were detected for the rs1799983 and rs2070744 polymorphisms. 30140993 2018
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.100 GeneticVariation BEFREE In this study, a case-control study was carried out to investigate the effects of 7 SNPs in ACE gene and 2 SNPs in eNOS gene in the development of DN in Northern China.7 SNPs including A240T, A2350G, A5466C, A2215G, T3892C, C1237T and C3409T of ACE gene and 2 SNPs (G894T and T786C) of eNOS gene were genotyped by polymerase chain reaction restriction fragment length polymorphism method. 25227524 2015
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.100 GeneticVariation BEFREE For eNOS-G894T, there was an association between T allele and DN risk in the global, Asian and African population in DN/T2DM group. 26489520 2015
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.100 GeneticVariation BEFREE G894T polymorphism was associated with DN only in allele contrast and in co-dominance model. 24433471 2014
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.100 GeneticVariation BEFREE We ascertained the significant effect of the NOS3 894G>T variant on DN progression and occurrence of major cardiovascular event in T2DM subjects. 24603156 2013
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.100 GeneticVariation BEFREE To investigate the association of functional single nucleotide polymorphisms (SNPs) of the endothelial nitric oxide synthase gene (eNOS) gene (T-786C, G894T) and one variable number tandem repeat polymorphism (aa 27VNTR bb) with reno-protective response to angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) therapy in North Indian type 2 diabetic mellitus (T2DM) subjects with cases having diabetic nephropathy (DN) and controls without DN. 23260854 2013
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.100 GeneticVariation BEFREE However, a link between eNOS Glu298Asp gene polymorphism and DN risk was not found in overall populations, Asians, Caucasians, and Brazil population. 23113598 2013
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.100 GeneticVariation BEFREE The aim of this study was to evaluate the association of three polymorphisms of the eNOS gene (894G>T, -786T>C, and 27-bp-VNTR) with the risk of DN among type 2 diabetic patients. 22313046 2012
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.100 GeneticVariation BEFREE The evidence accumulated suggested that 4b/a and G894T polymorphisms in the eNOS gene were associated with susceptibility to DN in Asian populations, but not in Caucasian populations. 21084433 2011
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.100 GeneticVariation BEFREE We performed a meta-analysis of 28 association studies focusing on three polymorphisms in the NOS3 gene (G894T (Glu289Asp), 4b/a, and T-786C) and the risk of DN published before July 2009, covering a total of 10,364 subjects. 20049477 2010
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.100 GeneticVariation BEFREE The meta-analysis showed that G894T is significantly associated with diabetic nephropathy and diabetes leading to severe nephropathy in type 2 diabetics and in East Asians, respectively. 19773668 2009
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.100 GeneticVariation BEFREE We evaluated the association of -786T>C (promoter region), Glu298Asp (Exon 7), and 4b4a (Intron 4) polymorphisms in eNOS gene with Type 2 diabetes mellitus (T2DM) and DN by haplotype analysis. 18413207 2008
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.100 GeneticVariation BEFREE In contrast, the T allele is associated with increased oxidative stress in the renal circulation in patients with diabetes suggesting a specific role of the G894T polymorphism in the pathogenesis of diabetic nephropathy. 18622262 2008
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.100 GeneticVariation BEFREE The Glu/Glu-genotype of the NOS3 Glu298Asp polymorphism may increase the risk of developing DN independently of other known risk factors. 17101543 2006
Diabetic Nephropathy
CUI: C0011881
Disease: Diabetic Nephropathy
0.100 GeneticVariation BEFREE Relations between eNOS Glu298Asp polymorphism and progression of diabetic nephropathy. 15331206 2004