|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Overall, our findings suggest that eNOS G894T and T-786C SNPs were both significantly correlated with hypertension</span>.
|
28287883 |
2017 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study evidenced that rs1799983 NOS3 polymorphism could be associated with hypertension and DBP among Southern Europeans, being this association influenced by dietary fat (SFA and MUFA) and body mass index.
|
26994605 |
2017 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of endothelial nitric oxide synthase (eNOS) gene G894T polymorphism with hypertension risk and complications.
|
27557897 |
2016 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further studies are needed to reveal the usefulness of G894T polymorphism in hyper</span>tension risk assessment in obese.
|
26579574 |
2015 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The relationship between the G894T polymorphism and hypertension in Han Chinese may be attributed to the difference in geographic background of subjects.
|
24846690 |
2015 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, GG phenotype of Glu298Asp polymorphism neither decreased the ESRD risk (OR = 0.77, 95% CI 0.55-1.08, P = 0.13) nor affected the hypertension risk (OR = 1.04, 95% CI 0.66-1.66, P = 0.86).
|
24995932 |
2014 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The genotypic distribution of the Met235Thr (AGT) and Glu298Asp (NOS3) polymorphisms demonstrated that both are independent risk factors of hypertension (p=0.02 and p=0.008, respectively).
|
22791701 |
2013 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Regarding the eNOS E298D polymorphism, the frequency of the mutant D allele carriage was only observed to be higher among cases with hypertension associated with diabetes and obesity, in comparison with controls, yet not reaching statistical significance (41.2% vs. 34%, p > 0.05).
|
23042814 |
2013 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of our study is to investigate whether genetic polymorphisms in the endothelial nitric oxide synthase (eNOS) gene (in the promoter region T(-786)C, in exon 7 (Glu298Asp) and in intron 4 (4b/4a)) or eNOS haplotypes are associated with hypertension in obese children and adolescents.
|
20661250 |
2011 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We, via a comprehensive meta-analysis, ascertained the role of eNOS G894T and 4b/a polymorphisms on hypertension in Asians, and T-786C polymorphism in Whites.
|
21912683 |
2011 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The NOS3 -786 T/C (SNP id rs2070744; http://www.ensembl.org ), intron 4 variable number tandem repeat (VNTR), and Glu298Asp (SNP id rs1799983) polymorphisms, have been associated with differences in NO plasma concentrations and with the risk of hypertension (HT) and ischemic cardiac disease.
|
21293869 |
2011 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease.
|
21816783 |
2011 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
To examine the relationship of three eNOS gene polymorphisms, T-786C (rs2070744), G894T (rs1799983), and G10T (rs7830), with hypertension</span> in the Han population in southwestern China, we carried out a study of the genotypes of three SNPs in 510 hypertensive and 510 normotensive subjects from the Yunnan Province by using PCR-RFLP and sequencing.
|
21968727 |
2011 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The polymorphism Glu298Asp of endothelial nitric oxide (eNOS) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial.
|
20083095 |
2010 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no significant interaction between dietary fat intake and NOS3 Glu298Asp genotype with regards to hypertension status in either African Americans or whites (P for interaction=0.3 and 0.4, respectively).
|
19960019 |
2010 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was an increased prevalence of hypertension and increased atria in Glu298Glu patients comparing with combined genotype Glu298Asp and Asp298Asp.
|
20079452 |
2010 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
No differences were observed in the distribution of G894T (Glu298Asp) NOS3 genotypes between the resistant hypertension group and the controlled hypertension patients.
|
19650939 |
2009 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
We revealed that a combination of the Arg16Gly and Glu298Asp polymorphisms in ADRB2 and NOS3, respectively, remarkably increased the risk for hypertension in middle-aged and elderly humans.
|
19373110 |
2009 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results of the present study support that homozygosity for +G894T (E298D) in NOS3 is a genetic risk factor for the development of LVH in patients with hypertension.
|
19132956 |
2009 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The AGT M235T and eNOS G894T polymorphisms are unlikely to play an important role in the pathogenesis of hypertension in Malays.
|
17977523 |
2008 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotype frequencies for the -786T/C, 4b/4a, and 894G/T polymorphisms differed significantly (P<0.001) between patients and controls and were associated with an increased risk of hypertension (OR=2.0, OR=3.8, OR=1.6, respectively).
|
18325347 |
2008 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Relation of the Glu298Asp polymorphism of the nitric oxide synthase gene to hypertension and serum cholesterol in Japanese workers.
|
18550157 |
2008 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, a G894T polymorphism in exon 7 of the eNOS gene has been reported to be associated with high blood pressure.
|
18164968 |
2008 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our data suggests that 894G>T plays a significant role in the mechanistic interaction between metabolic risk such as hypertension and MS, although sex-related differences may exist.
|
19169496 |
2008 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, a subgroup analysis adjusted with various cardiovascular risk factors confirmed positive association of the -786T>C polymorphism in CAD patients with hypertension and a smoking history and also a significant association of the intron 4 genotypes with a smoking history, but no significance has been found in the eNOS polymorphisms of 894G>T upon any risk adjustment.
|
16842840 |
2007 |