|
Kidney Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Endothelial nitric oxide synthase (eNOS) Glu298Asp single nucleotide polymorphism (SNP) genotype has been associated with a worse phenotype amongst patients with established heart failure and in patients with progression of their renal disease.
|
25612295 |
2015 |
|
Kidney Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
NOS3 894G>T polymorphism is associated with progression of kidney disease and cardiovascular morbidity in type 2 diabetic patients: NOS3 as a modifier gene for diabetic nephropathy?
|
24603156 |
2013 |
|
Kidney Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
We genotyped three polymorphisms of eNOS (two SNPs: T-786C, G894T and one 27 VNTR) in T2DM patients with overt nephropathy (cases: n=320) and T2DM patients without overt nephropathy (controls: n=490), using validated PCR-RFLP assays.
|
23260854 |
2013 |
|
Kidney Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C allele for -786T>C and the T allele for 894G>T were significantly more frequent in diabetics with nephropathy than in diabetics without nephropathy (p<0.001; odds ratio [OR] and 95% confidence interval [CI] for the C allele=1.64 [1.24-2.17] and p<0.001; OR and 95% CI=1.7 [1.27-2.26] for the T allele).
|
22313046 |
2012 |
|
Kidney Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
No associations between the -786T>C, the VNTR intron 4 a/b and the 894G>T (Glu298Asp) polymorphisms in the eNOS gene and renal disease were observed in type 2 diabetic Caucasian-Brazilians.
|
21255858 |
2011 |
|
Kidney Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
A total of 3793 patients (DN) and 3161 controls (diabetes without nephropathy) for 4b/a, 2654 patients and 1993 controls for G894T and 1348 patients and 1175 controls for T786C were included in our analysis.
|
21084433 |
2011 |
|
Kidney Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to evaluate the possible association between six SNPs (A-5466C, T-3892C, A-240T, C1237T, G2215A and A2350G) of the ACE gene and two SNPs (T-786C and G894T) of the eNOS gene with lupus nephropathy in a northern Chinese population.
|
20540812 |
2010 |
|
Kidney Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis showed that G894T is significantly associated with diabetic nephropathy and diabetes leading to severe nephropathy in type 2 diabetics and in East Asians, respectively.
|
19773668 |
2009 |
|
Kidney Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The G894T polymorphism of the eNOS gene is associated with severity of renal disease.
|
19376104 |
2009 |
|
Kidney Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
These mutant genotypes were found to be associated with higher risk of nephropathy (-786T > C: OR: 5.5, 95%CI: 1.53-19.79; 894G > T: OR: 1.8, 95%CI: 1.03-3.16; Intron 4: OR: 6.23, 95%CI: 2.23-16.31).
|
18401556 |
2008 |
|
Kidney Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
In contrast, we did not observe any association between the genotypes or alleles of G894T polymorphism with DR, hypertension, or nephropathy.
|
18079690 |
2007 |