rs1799983, NOS3

N. diseases: 246
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Erectile dysfunction
CUI: C0242350
Disease: Erectile dysfunction
0.100 GeneticVariation BEFREE The frequencies of Intron 4 VNTR a/a allele and Glu298Asp GT allele were associated with severe ED, while a/b and TT were associated with moderate or mild, and b/b and GG were associated with no ED. 30977424 2019
Erectile dysfunction
CUI: C0242350
Disease: Erectile dysfunction
0.100 GeneticVariation BEFREE Our meta-analysis showed that the two single nucleotide polymorphisms in eNOS gene, G894T</span> and T-786C, are strongly associated with the risk of erectile dysfunction. 26908069 2018
Erectile dysfunction
CUI: C0242350
Disease: Erectile dysfunction
0.100 GeneticVariation BEFREE The G894T and T786C polymorphisms showed a significant association with ED risk in Caucasians (GT + TT versus GG for G894T: OR = 2.13, 95% CI = 1.08-4.19; CC versus CT + TT for T786C: OR = 3.29, 95% CI = 2.30-4.72) and Asians (GT + TT versus GG for G894T: OR = 2.08, 95% CI = 1.53-2.84; CC + CT versus TT for T786C: OR = 3.13, 95% CI = 1.35-7.25). 29654965 2018
Erectile dysfunction
CUI: C0242350
Disease: Erectile dysfunction
0.100 GeneticVariation BEFREE An increased risk for earlier onset of ED was observed in the G894T risk genotype carriers (odds ratio = 3.572; P < .020). 28268155 2017
Erectile dysfunction
CUI: C0242350
Disease: Erectile dysfunction
0.100 GeneticVariation BEFREE The eNOS polymorphisms G894T, 4 VNTR, and T786C were associated with an increased risk for ED. 25940782 2015
Erectile dysfunction
CUI: C0242350
Disease: Erectile dysfunction
0.100 GeneticVariation BEFREE Our investigations demonstrate that eNOS G894T polymorphism might protect men against ED</span> risk. 25726156 2015
Erectile dysfunction
CUI: C0242350
Disease: Erectile dysfunction
0.100 GeneticVariation BEFREE We studied 118 patients; 63 patients had ED secondary to radical prostatectomy (PED) and 55 had organic, clinical ED. eNOS genotypes for three eNOS polymorphisms (T(-786)C, rs2070744; a variable number of tandem repeats (VNTR) in intron 4; and Glu298Asp, rs1799983) were determined, and eNOS haplotypes were estimated using PHASE 2.1. 22064666 2013
Erectile dysfunction
CUI: C0242350
Disease: Erectile dysfunction
0.100 GeneticVariation BEFREE The association of eNOS G894T polymorphism with metabolic syndrome and erectile dysfunction. 22304542 2012
Erectile dysfunction
CUI: C0242350
Disease: Erectile dysfunction
0.100 GeneticVariation BEFREE To evaluate a potential association between the G894T polymorphism in the eNOS gene and ED complaints in a population-based sample in São Paulo, Brazil. 19968769 2010
Erectile dysfunction
CUI: C0242350
Disease: Erectile dysfunction
0.100 GeneticVariation BEFREE The result supports that G894T variant is associated with an increase in the risk of ED. 20722785 2010
Erectile dysfunction
CUI: C0242350
Disease: Erectile dysfunction
0.100 GeneticVariation BEFREE Logistic regression analysis showed that G894T polymorphism was an independent risk factor for ED. 19473288 2009
Erectile dysfunction
CUI: C0242350
Disease: Erectile dysfunction
0.100 GeneticVariation BEFREE The eNOS 894T allele carriers had significantly higher frequencies of ED and higher IPSS, suggesting that eNOS G894T gene polymorphisms may play an implication as a genetic susceptibility factor for both ED and BPH/LUTS. 19515207 2009
Erectile dysfunction
CUI: C0242350
Disease: Erectile dysfunction
0.100 GeneticVariation BEFREE ACE gene I/D and NOS3 G894T polymorphisms and response to sildenafil in men with erectile dysfunction. 12837457 2003