|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis establishes that the G894T</span> and 4b/a polymorphisms of eNOS gene are significantly associated with the risk of IS.
|
28084234 |
2019 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
The findings of the present study suggest that polymorphism in G894T position of eNOS gene might be a risk factor for IS mainly for LVD stroke subtype in North Indian population.
|
27168380 |
2016 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
The study concluded that SNP G894T variant is associated with ischemic stroke and might contribute to ischemic stroke susceptibility in North Indians.
|
26994413 |
2015 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
Two NOS3 SNP [894G/T and 2479G/A] variants and NOx levels are associated with ischemic stroke in young Asian Indians.
|
24986538 |
2014 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
For eNOS G894T polymorphism, the results indicated that TT genotype was significantly associated with increased risk of IS incidence compared to G allele (OR and 95 % CI 1.25 (1.09-1.42) for TT vs. GT+GG, P < 0.001).
|
24573998 |
2014 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the present study, we aimed to investigate the relationship between endothelial nitric oxide synthase 3 (NOS3) G894T, T-786C, and intron 4 variable number of tandem repeat (VNTR) variants, alone or in combination, and the risk of incidence of ischemic stroke in the Turkish population.
|
25321404 |
2014 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our comprehensive meta-analysis ascertains that the G894T, 4b/a, and T786C polymorphisms are associated with ischemic stroke risk in Asians.
|
23560937 |
2013 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
The meta-analysis indicated that eNOS gene 4b/a, T-786C, G894T polymorphism might be associated with IS.
|
23544143 |
2013 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
For G894T and 4b/a, a significant association of 894T allele and 4a allele with increased risk of IS was found in Asians (TT+GT vs. GG: p<0.00001, OR=1.60, 95% CI=1.38-1.79, Pheterogeneity=0.11; aa+ba vs. bb: P<0.00001, OR=1.60, 95% CI=1.30-1.97, Pheterogeneity=0.02), but not in Caucasians (TT+GT vs. GG: P=0.60, OR=0.94, 95% CI=0.75-1.19, Pheterogeneity=0.002; aa+ba vs. bb: P=0.13, OR=0.81, 95% CI=0.62-1.06, Pheterogeneity=0.63).
|
23845784 |
2013 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
Previous studies have shown that ischemic stroke (IS) was closely associated with the Glu298Asp polymorphism in the eNOS gene and the 677C-T (Ala→Val) polymorphism in methylenetetrahydrofolate reductase (MTHRF) gene.
|
22940147 |
2012 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
Endothelial nitric oxide synthase Glu298Asp, 4b/a, and -786T>C gene polymorphisms and the risk of ischemic stroke.
|
19804474 |
2010 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association of T-786C, G894T and 4a/b polymorphisms in the endothelial nitric oxide synthase (eNOS) gene with early-onset ischemic stroke in South Indians.
|
20037257 |
2010 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further research is warranted to clarify the relevance of G894T polymorphisms to ischemic stroke.
|
19447301 |
2009 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggested the lack of the association between the Glu298Asp gene polymorphism and ischemic stroke or subtypes of ischemic stroke in the Turkish population.
|
18781402 |
2009 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
Three polymorphisms of the eNOS gene (-922A/G, -786T/C, 894G/T) were determined by using TaqMan SNP genotyping assay in 309 Chinese patients with IS and 309 Chinese controls.
|
18396156 |
2008 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association of polymorphisms in the nitric oxide synthase 3 (NOS3) gene (T-786C, variable number tandem repeats 4A/B/C, and G894T) and in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T) with acute ischemic stroke have been reported.
|
19049547 |
2008 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
For one of these SNPs, the glu298asp polymorphism in the nitric oxide synthase 3 gene, an association with ischemic stroke was replicated in the second study and also in a combined analysis of both studies.
|
17165044 |
2007 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
We are unable to confirm previous reports of an association of the intron 4a or the G894T alleles with ischemic stroke.
|
18070351 |
2007 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, it is the interplay of both environmental and common genetic factors [such as the Leiden V, methylenetetrahydrofolate reductase C677T, apolipopotein E 4, endothelial nitric oxide synthase G894T, angiotensin-converting enzyme I/D and angiotensin II type 1 receptor A1166C mutations and polymorphisms] that leads to the development of ischaemic stroke.
|
16787209 |
2006 |
|
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
The eNOS G894T or eNOS 894TT genotypes in combination with the MTHFR 677TT or ACE D/D genotype increases the risk of ischaemic stroke.
|
15595935 |
2005 |