Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
BEFREE |
We identified an exonic polymorphism in NOS3 (rs1799983, p.Glu298Asp; p = 2.2E-8, odds ratio [OR] = 1.05, 95% confidence interval [CI] = 1.04-1.07) and variants in an intron of COL4A1 (rs9521634; p = 3.8E-8, OR = 1.04, 95% CI = 1.03-1.06) and near DYRK1A (rs720470; p = 6.1E-9, OR = 1.05, 95% CI = 1.03-1.07) at genome-wide significance for stroke.
|
30383316 |
2018 |
Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
GWASCAT |
We identified an exonic polymorphism in NOS3 (rs1799983, p.Glu298Asp; p = 2.2E-8, odds ratio [OR] = 1.05, 95% confidence interval [CI] = 1.04-1.07) and variants in an intron of COL4A1 (rs9521634; p = 3.8E-8, OR = 1.04, 95% CI = 1.03-1.06) and near DYRK1A (rs720470; p = 6.1E-9, OR = 1.05, 95% CI = 1.03-1.07) at genome-wide significance for stroke.
|
30383316 |
2018 |
Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
BEFREE |
In conclusion, genotypic polymorphisms of the eNOS Glu298Asp and Cav-1 14713A/29107A polymorphisms are associated with the elevated risk of LAA stroke among Han Chinese in Taiwan.
|
28346478 |
2017 |
Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
BEFREE |
AF patients with rs1799983 variants were more likely to have coronary artery disease or stroke than those without genetic variant at this gene (31.0% vs. 17.3%, p=0.004).
|
26256966 |
2015 |
Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
BEFREE |
However, the copresence of G894T and intron 4 VNTR risk-elevating genotypes in the same individual increased the risk of stroke seven times (odds ratio=7.083, 95% confidence interval=0.866-57.963, p=0.029).
|
25321404 |
2014 |
Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
BEFREE |
Thus, we examined the possible association of eNOS G894T variation with stroke severity and functional outcome.
|
22004707 |
2011 |
Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
BEFREE |
We tested a single nucleotide polymorphism (SNP) in endothelial nitric oxide synthase (NOS3) gene at codon 298 (single-nucleotide polymorphism rs1799983; p.Asp298Glu) in a cohort of 355 older (>75 years) stroke survivors, who had detailed cognitive assessments from 3 months poststroke, i.e., baseline when the patients were free of dementia and subsequently at annual intervals.
|
20691505 |
2011 |
Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
BEFREE |
In order to investigate the influence of genetic factors in childhood stroke, we compared the distributions of mutations/ polymorphisms affecting hemostasis and/or endothelial function (factor V [FV] Leiden, factor II [FII] G20210A, methylenetetrahydrofolate reductase [MTHFR] C677T, angiotensin-converting enzyme [ACE] insertion/deletion [ID], and endothelial nitric oxide synthase [eNOS] G894T) among children with stroke and controls.
|
19372095 |
2009 |
Cerebrovascular accident
|
|
0.780 |
GeneticVariation
|
BEFREE |
In pooled analysis of all patients, intron 4c, but not intron 4a, intron 4b or G894T alleles are associated with stroke (p < 0.01).
|
18070351 |
2007 |
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs1799983-T and rs891512-A alleles and interaction between rs1799983 and smoking were all risk factors of CHD.
|
31567371 |
2020 |
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Glu298Asp is a single nucleotide polymorphism (SNP) in the eNOS gene related to the risk of cardiovascular disease.
|
31442681 |
2020 |
Erectile dysfunction
|
|
0.100 |
GeneticVariation
|
BEFREE |
The frequencies of Intron 4 VNTR a/a allele and Glu298Asp GT allele were associated with severe ED, while a/b and TT were associated with moderate or mild, and b/b and GG were associated with no ED.
|
30977424 |
2019 |
Myocardial Infarction
|
|
0.100 |
GeneticVariation
|
BEFREE |
When we stratified data based on type of disease, we found that the rs1799983, rs2070744 and rs869109213 polymorphisms were all significantly correlated with the risk of myocardial infarction or acute coronary syndrome in certain genetic models.
|
30789045 |
2019 |
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further subgroup analyses according to ethnicity of participants revealed that the rs1799983 and rs2070744 polymorphisms were significantly associated with the risk of coronary artery disease in both Caucasians and Asians, whereas the rs869109213 polymorphism was only associated with the risk of coronary artery disease in Caucasians.
|
30789045 |
2019 |
Ischemic stroke
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis establishes that the G894T</span> and 4b/a polymorphisms of eNOS gene are significantly associated with the risk of IS.
|
28084234 |
2019 |
Coronary Arteriosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further subgroup analyses according to ethnicity of participants revealed that the rs1799983 and rs2070744 polymorphisms were significantly associated with the risk of coronary artery disease in both Caucasians and Asians, whereas the rs869109213 polymorphism was only associated with the risk of coronary artery disease in Caucasians.
|
30789045 |
2019 |
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings show that the 27-bp VNTR polymorphic locus, but not the c.894G>T polymorphic locus, is associated with CAD and that it may regulate NOS3 pre-mRNA splicing in a length-dependent manner.
|
30447355 |
2019 |
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Further subgroup analyses according to ethnicity of participants revealed that the rs1799983 and rs2070744 polymorphisms were significantly associated with the risk of coronary artery disease in both Caucasians and Asians, whereas the rs869109213 polymorphism was only associated with the risk of coronary artery disease in Caucasians.
|
30789045 |
2019 |
Coronary Artery Disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The association between the <i>NOS3</i> rs1799983 polymorphism and CAD may be partly mediated by abnormal NO and lipid levels caused by the T allele.
|
31138610 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.100 |
GeneticVariation
|
BEFREE |
In present study we aim to assess the association of eNOS (G894T, rs1799983) and NET (G1287A, rs5569) genes polymorphism with T2DM.
|
31377977 |
2019 |
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, we also found that the rs1799983 polymorphism was significantly associated with the susceptibility to peripheral artery disease, whereas the rs2070744 polymorphism was significantly associated with the susceptibility to coronary artery disease in DM patients.
|
30140993 |
2018 |
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
As for vascular complications in DM, significant associations with the susceptibility to diabetic nephropathy were detected for the rs1799983 and rs2070744 polymorphisms.
|
30140993 |
2018 |
Atherosclerosis
|
|
0.100 |
GeneticVariation
|
BEFREE |
The NOS3 G894T polymorphic variant also correlated with atherosclerosis, an association probably mediated by the traditional risk factors for CVD.
|
29948131 |
2018 |
Coronary heart disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, the eNOS G894T gene polymorphism was associated with the occurrence and development of CHD in young people.
|
29359785 |
2018 |
Cardiovascular Diseases
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interaction between endothelial nitric oxide synthase rs1799983, cholesteryl ester-transfer protein rs708272 and angiopoietin-like protein 8 rs2278426 gene variants highly elevates the risk of type 2 diabetes mellitus and cardiovascular disease.
|
29973202 |
2018 |