Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.720 GeneticVariation BEFREE In this case-control study, we aimed to investigate whether single nucleotide polymorphisms in the BIN1 (rs744373) and IL-6 (rs1800795) genes are associated with AD. 26733302 2016
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.720 GeneticVariation GWASCAT A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin. 26545630 2016
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.720 GeneticVariation BEFREE Regression analysis revealed that the presence of both rs1801133 T and rs1800795 C alleles increased the odds of developing AD by 2.5 and VaD by 3.7-fold. 22015309 2012
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE Nevertheless, in the subgroup analysis by ethnicity, we identified that <i>IL-6</i>-rs1800795 polymorphism was associated with an increased risk of PCa for Caucasian individuals in dominant model (MM + MW vs. WW: OR = 1.245, 95%CI = 1.176-1.318, <i>P</i> < 0.001). 30854108 2019
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE The C allele of rs1800795 was associated with PCa r</span>isk in the assessed population (OR (95% CI) = 1.45 (1.06-1.98)). 30345492 2019
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.070 GeneticVariation BEFREE Nevertheless, in the subgroup analysis by ethnicity, we identified that <i>IL-6</i>-rs1800795 polymorphism was associated with an increased risk of PCa for Caucasian individuals in dominant model (MM + MW vs. WW: OR = 1.245, 95%CI = 1.176-1.318, <i>P</i> < 0.001). 30854108 2019
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.070 GeneticVariation BEFREE The C allele of rs1800795 was associated with PCa r</span>isk in the assessed population (OR (95% CI) = 1.45 (1.06-1.98)). 30345492 2019
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.070 GeneticVariation BEFREE The Role of Interleukin-6 Polymorphism (rs1800795) in Prostate Cancer Development and Progression. 29848725 2018
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE An association of the rs1800795 SNP of the IL-6 gene with T2D has been detected for the first time in Cretans. 29957071 2018
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE The Role of Interleukin-6 Polymorphism (rs1800795) in Prostate Cancer Development and Progression. 29848725 2018
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE Overall estimates revealed no significant relationship between IL-6 rs1800795 polymorphism and prostate cancer risk in total analysis, but a risk-increasing effect of the polymorphism was detected in African-American subgroup under CC versus GG and CC versus GG + GC contrasts (OR 3.43, 95% CI 1.01-11.71; OR 3.51, 95% CI 1.04-11.82) after subgroup analysis by ethnicity.IL-6 rs1800795 polymorphism may enhance the susceptibility to prostate cancer in African-American men. 28296724 2017
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.070 GeneticVariation BEFREE Overall estimates revealed no significant relationship between IL-6 rs1800795 polymorphism and prostate cancer risk in total analysis, but a risk-increasing effect of the polymorphism was detected in African-American subgroup under CC versus GG and CC versus GG + GC contrasts (OR 3.43, 95% CI 1.01-11.71; OR 3.51, 95% CI 1.04-11.82) after subgroup analysis by ethnicity.IL-6 rs1800795 polymorphism may enhance the susceptibility to prostate cancer in African-American men. 28296724 2017
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE IL-6 genotypes of rs1800795 GC and rs1800796 GG might point to a relatively high risk for T2D patients suffering from PDR in a Chinese population and they were associated with elevation of IL-6 expression in both mRNA and protein. 28651253 2017
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer. 26535651 2015
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.070 GeneticVariation BEFREE We investigated the role of two functional polymorphisms, IL-6-174G>C (rs1800795) and IL-6-572C>G (rs1800796), in the development of prostate cancer. 26535651 2015
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE Direct sequencing of the PCR amplicon from genomic DNA was used for genotyping rs1800795 in all subjects [age-matched controls (N = 140) and prostate cancer patients (N = 164)]. 24446297 2014
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.070 GeneticVariation BEFREE Direct sequencing of the PCR amplicon from genomic DNA was used for genotyping rs1800795 in all subjects [age-matched controls (N = 140) and prostate cancer patients (N = 164)]. 24446297 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Interleukin-6 (IL-6)-597 A/G (rs1800797) & -174 G/C (rs1800795) gene polymorphisms in type 2 diabetes. 25222779 2014
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Recent studies identified a significant interaction between body mass index (BMI) and the rs1800795 polymorphism of the interleukin-6 gene that influences both IR and onset of type 2 diabetes mellitus, with obese individuals homozygous for the C allele demonstrating the highest level of IR and greatest risk for type 2 diabetes mellitus. 22075267 2012
Malignant neoplasm of prostate
CUI: C0376358
Disease: Malignant neoplasm of prostate
0.070 GeneticVariation BEFREE SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation. 19267250 2009
Prostate carcinoma
CUI: C0600139
Disease: Prostate carcinoma
0.070 GeneticVariation BEFREE SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation. 19267250 2009
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE This study examined a possible association of the G>C polymorphism at nucleotide -174 in the promoter region of the interleukin-6 (IL-6) gene (rs1800795) with the prevalence of diabetic complications in 235 patients with type 1 and 498 patients with type 2 diabetes. 19140096 2009
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results. 18752089 2009
Diabetes Mellitus, Non-Insulin-Dependent
0.070 GeneticVariation BEFREE Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, -174G>C (rs1800795) and -573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. 17003362 2006
Ischemic stroke
CUI: C0948008
Disease: Ischemic stroke
0.060 GeneticVariation BEFREE Our findings indicated that IL-6 rs1800795 polymorphism was significantly associated with individual susceptibility to IS in Asians, but not in Caucasians. 31446341 2019